Auditory induced vestibular (otolithic) processing revealed by an independent component analysis: an fMRI parametric analysis

Oh, Sun-Young; Boegle, Rainer; Ertl, Matthias; Eulenburg, Peter zu; Stephan, Thomas; Dieterich, Marianne

doi:10.1007/s00415-017-8430-2

Cited by 3 publications

(4 citation statements)

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“…In addition, some regions only responded to stimulation above the vestibular threshold, suggesting that vestibular (otolith) signals are processed in the inferior insula, IPL, and cerebellum (27). These data indicate that the STG, insula, and IPL, including the parietal operculum, could contain information for multisensory vestibular integration, i.e., an important hub for higher vestibular cognition tasks such as spatial localization (27, 30). In another words, these brain areas are part of a complex neural network for vestibular and visuospatial processing and memory (36, 37).…”

Section: Discussionmentioning

confidence: 81%

“…In the current study, WE patients had impaired VOR and vestibular deafferentation with the MVN and NPH lesions in the brainstem which caused vestibular cortical hypofunction reflected by decreased rs-fc in the vestibular processing regions. Rs-fc decreased in regions that are core for vestibular cortical processing and integrating multisensory signals into a perception of spatial orientation and self-motion (28–30). Therefore, dysfunction in these areas might be linked with spatial and other higher vestibular cognitive dysfunctions.…”

Section: Discussionmentioning

confidence: 99%

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Altered Resting-State Functional Connectivity in Wernicke's Encephalopathy With Vestibular Impairment

Lee

Kang

et al. 2019

Front. Neurol.

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Objectives: To reveal the neural basis of Wernicke's encephalopathy (WE) with impaired vestibulo-ocular reflex (VOR), we evaluated resting-state functional connectivity (rs-fc) in the vestibular processing brain regions.Methods: Rs-fc between the vestibular regions and the rest of the brain were compared with neurotological features including the head-impulse tests (vHIT) and caloric responses in patients with WE (n = 5, mean age 53.4 ± 10 years) and healthy controls (n = 20, mean age 55.0 ± 9.2 years). Rs-fc analyses employed a region of interest (ROI)-based approach using regions selected a priori that participate in vestibular processing including the cerebellar vermis, insula, parietal operculum, and calcarine cortex.Results: The main neurologic findings for patients with WE were mental changes; gait ataxia; spontaneous and gaze-evoked nystagmus (GEN); and bilaterally positive HIT for the horizontal canals. Video HIT documented bilateral horizontal canal dysfunction with decreased gain and corrective saccades. Caloric irrigation and rotation chair testing revealed prominent bilateral horizontal canal paresis. Patients with WE also had decreased spatial memory, which substantially recovered after treatments. Functional connections at the predefined seed regions, including the insular cortex and parietal operculum, were attenuated in the WE group compared to healthy controls.Conclusions: WE is related to impaired VOR and visuospatial dysfunction, and fMRI documented changes in the rs-fc of multisensory vestibular processing regions including the insula, parietal operculum, and superior temporal gyrus, which participate in integration of vestibular perception.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Altered Resting-State Functional Connectivity in Wernicke's Encephalopathy With Vestibular Impairment

Lee

Kang

et al. 2019

Front. Neurol.

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“…The validity of this approach has been confirmed in recent fMRI studies. An independent component analysis revealed a specific increase in BOLD response for SVS above the vestibular threshold in areas such as the insula, precuneus, inferior parietal lobule, middle cingulate cortex, and cerebellar uvula ( 116 ). Subsequent parametric analyses revealed vestibular-auditory integration in the caudal part of the superior temporal gyrus and posterior insula ( 117 ).…”

Section: Vestibular Stimulation For Neuroimaging Studies and Their Application To Vestibular-evoked Potentialsmentioning

confidence: 99%

Vestibular-Evoked Cerebral Potentials

2021

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The human vestibular cortex has mostly been approached using functional magnetic resonance imaging and positron emission tomography combined with artificial stimulation of the vestibular receptors or nerve. Few studies have used electroencephalography and benefited from its high temporal resolution to describe the spatiotemporal dynamics of vestibular information processing from the first milliseconds following vestibular stimulation. Evoked potentials (EPs) are largely used to describe neural processing of other sensory signals, but they remain poorly developed and standardized in vestibular neuroscience and neuro-otology. Yet, vestibular EPs of brainstem, cerebellar, and cortical origin have been reported as early as the 1960s. This review article summarizes and compares results from studies that have used a large range of vestibular stimulation, including natural vestibular stimulation on rotating chairs and motion platforms, as well as artificial vestibular stimulation (e.g., sounds, impulsive acceleration stimulation, galvanic stimulation). These studies identified vestibular EPs with short latency (<20 ms), middle latency (from 20 to 50 ms), and late latency (>50 ms). Analysis of the generators (source analysis) of these responses offers new insights into the neuroimaging of the vestibular system. Generators were consistently found in the parieto-insular and temporo-parietal junction—the core of the vestibular cortex—as well as in the prefrontal and frontal areas, superior parietal, and temporal areas. We discuss the relevance of vestibular EPs for basic research and clinical neuroscience and highlight their limitations.

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“…In the few studies available calculating signal decreases during unilateral VEMP stimulation short tone burst induced otolith stimulation was continuously applied with a repetition rate of 2.5-3 Hz during the stimulation blocks, which might lead to an ongoing central vestibular effect that also results in an inhibitory interaction pattern, although the stimulus per se is very short [21,38,90]. A recent 3 T MRI independent component analyses study during VEMP stimulation in fact detected negative correlations or decreased event-related BOLD-responses as part of the reciprocal inhibitory visual-vestibular interaction [91].…”

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confidence: 99%

Direct comparison of activation maps during galvanic vestibular stimulation: A hybrid H2[15 O] PET—BOLD MRI activation study

et al. 2020

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Previous unimodal PET and fMRI studies in humans revealed a reproducible vestibular brain activation pattern, but with variations in its weighting and expansiveness. Hybrid studies minimizing methodological variations at baseline conditions are rare and still lacking for task-based designs. Thus, we applied for the first time hybrid 3T PET-MRI scanning (Siemens mMR) in healthy volunteers using galvanic vestibular stimulation (GVS) in healthy volunteers in order to directly compare H 2 15 O-PET and BOLD MRI responses. List mode PET acquisition started with the injection of 750 MBq H 2 15 O simultaneously to MRI EPI sequences. Group-level statistical parametric maps were generated for GVS vs. rest contrasts of PET, MR-onset (event-related), and MR-block. All contrasts showed a similar bilateral vestibular activation pattern with remarkable proximity of activation foci. Both BOLD contrasts gave more bilateral widespread activation clusters than PET; no area showed contradictory signal responses. PET still confirmed the right-hemispheric lateralization of the vestibular system, whereas BOLD-onset revealed only a tendency. The reciprocal inhibitory visual-vestibular interaction concept was confirmed by PET signal decreases in primary and secondary visual cortices, and BOLD-block decreases in secondary visual areas. In conclusion, MRI activation maps contained a mixture of CBF measured using H 2

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Auditory induced vestibular (otolithic) processing revealed by an independent component analysis: an fMRI parametric analysis

Cited by 3 publications

References 14 publications

Altered Resting-State Functional Connectivity in Wernicke's Encephalopathy With Vestibular Impairment

Altered Resting-State Functional Connectivity in Wernicke's Encephalopathy With Vestibular Impairment

Vestibular-Evoked Cerebral Potentials

Direct comparison of activation maps during galvanic vestibular stimulation: A hybrid H2[15 O] PET—BOLD MRI activation study

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