Repeated corticosterone injections in adult mice alter stress hormonal receptor expression in the cerebellum and motor coordination without affecting spatial learning

Harlé, Guillaume; Lalonde, Robert; Fonte, Coralie; Ropars, Armelle; Frippiat, Jean-Pol; Strazielle, C.

doi:10.1016/j.bbr.2017.02.035

Cited by 22 publications

(9 citation statements)

References 49 publications

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“…Possible mediation of this effect by the cerebellum is indicated by the positive correlation found between latencies before falling off the rod and increased molecular layer thickness of crus 2, possibly caused by glucocorticoidmediated alterations in growth factors (Mocchetti et al, 1996). In contrast, rotorod acquisition slowed down in adult mice injected with CORT on P2-P14 (Howard and Granoff, 1968), adult rats injected with dexamethasone on P7 (Benesova and Pavlik, 1989), or mice injected and tested with CORT as adults (Harlé et al, 2017). CORT given on P2-P14 also slowed down the cerebellar-mediated conditioned eye-blink reflex in adult rats (Wilber et al, 2011), but when given on P15-P17 facilitated at P28 trace eye-blink conditioning, a hippocampal-mediated task (Wentworth-Eidsaune et al, 2016), though the latter result depended on type of hormone delivery (Claflin et al, 2005(Claflin et al, , 2014.…”

Section: Discussionmentioning

confidence: 99%

“…Six litters were used in each group and the mouse pups (n=3-4 males in each litter) were injected with CORT (Sigma-Aldrich, France) at a supra-physiological concentration of 20 mg/kg (CORT-treated mice; n=11), based on a medium dose range where behavioral effects were obtained (Harlé et al, 2017) or else injected with dimethylsulfoxide (DMSO) used as the vehicle (control mice; n=10) from P8 to P29, day of birth being recorded as P1. In each litter, both types of treatment were distributed equally between the males to minimize a litter effect.…”

Section: Animalsmentioning

confidence: 99%

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Effects of corticosterone injections in mid-to-late mouse postnatal development on adult motor activity and coordination

Hernandez

Harlé

Lalonde

et al. 2021

Neuroscience Research

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Glucocorticoids are involved in the developing brain but, in excessive amounts, may depress its growth and cause psychomotor development disorders. To test the long-term vulnerability of motor structures such as the cerebellum to supraphysiological corticosterone (CORT), the hormone was subcutaneously delivered at a dose of 20 mg/kg from postnatal day (P) 8 to P29 in C57BL/6 male mice evaluated for sensorimotor functions at P15, P22, P29, and 3 months. Relative to placebo, CORT increased motor activity in the open-field at P29 and 3 months as well as facilitating rotorod acquisition and visuomotor control necessary for swimming towards a visible goal without affecting spatial learning in the Morris water maze. CORT caused lobulespecific effects on cerebellar morphology by decreasing granule cell layer thickness in simplex lobule but increasing molecular and granule cell layer thickness in crus 2. The functional impact of these changes is indicated by significant correlations found between cerebellar size and activity levels or proficiency on the rotorod test of motor coordination.

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Section: Discussionmentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

Effects of corticosterone injections in mid-to-late mouse postnatal development on adult motor activity and coordination

Hernandez

Harlé

Lalonde

et al. 2021

Neuroscience Research

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“…CTNE also negatively affected balance and motor coordination in our study, in agreement with previous studies in mice exposed to chronic noise (Jafari et al., 2018; Tamura et al., 2012). These and other studies have demonstrated that stress‐induced HPA‐axis hyperactivity can alter the motor performance by affecting skilled movements, postural adjustments, and balance coordination (Harle et al., 2017; Jafari et al., 2017, 2018; Metz, 2007; Metz et al., 2001, 2005).…”

Section: Discussionmentioning

confidence: 80%

Traffic noise exposure, cognitive decline, and amyloid‐beta pathology in an AD mouse model

Karem

Mehla

Kolb

et al. 2020

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Concerns are growing that exposure to environmental pollutants, such as traffic noise, might cause cognitive impairments and predispose individuals toward the development of Alzheimer's disease (AD) dementia. In this study in a knock‐in mouse model of AD, we investigated how chronic traffic noise exposure (CTNE) impacts cognitive performance and amyloid‐beta (Aβ) pathology. A group of APPNL‐G‐F/NL‐G‐F mice was exposed to CTNE (70 dBA, 8 hr/day for 1 month) and compared with nonexposed counterparts. Following CTNE, an increase in hypothalamic–pituitary–adrenal (HPA) axis responsivity was observed by corticosterone assay of the blood. One month after CTNE, the CTNE group demonstrated impairments in cognitive and motor functions, and indications of anxiety‐like behavior, relative to the control animals. The noise‐exposed group also showed elevated Aβ aggregation, as inferred by a greater number of plaques and larger average plaque size in various regions of the brain, including regions involved in stress regulation. The results support that noise‐associated dysregulation of the neuroendocrine system as a potential risk factor for developing cognitive impairment and Aβ pathology, which should be further investigated in human studies.

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“…Amongst the most variable genes cerebellar genes occurred such as Pcp2. Even if the observed differences did not reach statistical significance, it is of note that corticosterone injections are able to affect motor coordination in mice ( Harle et al, 2017 ) and that social defeat elicits motor impairment ( Tomas-Roig et al, 2016 ).…”

Section: Discussionmentioning

confidence: 97%

N6 -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice

Guilherme

Tsoutsouli

Todorov

et al. 2021

Front. Cell Dev. Biol.

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Appropriately responding to stressful events is essential for maintaining health and well-being of any organism. Concerning social stress, the response is not always as straightforward as reacting to physical stressors, e.g., extreme heat, and thus has to be balanced subtly. Particularly, regulatory mechanisms contributing to gaining resilience in the face of mild social stress are not fully deciphered yet. We employed an intrinsic social hierarchy stress paradigm in mice of both sexes to identify critical factors for potential coping strategies. While global transcriptomic changes could not be observed in male mice, several genes previously reported to be involved in synaptic plasticity, learning, and anxiety-like behavior were differentially regulated in female mice. Moreover, changes in N6-methyladenosine (m6A)-modification of mRNA occurred associated with corticosterone level in both sexes with, e.g., increased global amount in submissive female mice. In accordance with this, METTL14 and WTAP, subunits of the methyltransferase complex, showed elevated levels in submissive female mice. N6-adenosyl-methylation is the most prominent type of mRNA methylation and plays a crucial role in processes such as metabolism, but also response to physical stress. Our findings underpin its essential role by also providing a link to social stress evoked by hierarchy building within same-sex groups. As recently, search for small molecule modifiers for the respective class of RNA modifying enzymes has started, this might even lead to new therapeutic approaches against stress disorders.

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Repeated corticosterone injections in adult mice alter stress hormonal receptor expression in the cerebellum and motor coordination without affecting spatial learning

Cited by 22 publications

References 49 publications

Effects of corticosterone injections in mid-to-late mouse postnatal development on adult motor activity and coordination

Effects of corticosterone injections in mid-to-late mouse postnatal development on adult motor activity and coordination

Traffic noise exposure, cognitive decline, and amyloid‐beta pathology in an AD mouse model

N6 -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice

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