Development of a paper-based microfluidic analytical device by a more facile hydrophobic substrate generation strategy

Xue, Yuanyuan; Zhang, Wentao; Zhang, Mengyue; Liu, Lizhi; Zhu, Wenxin; Yan, Litao; Wang, Jing; Wang, Yanru; Wang, Jianlong; Zhang, Daohong

doi:10.1016/j.ab.2017.03.001

Cited by 9 publications

(3 citation statements)

References 35 publications

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“…However, paper-based lab-on-a-chip (LOC) is the latest innovation, with the advantage of a low fabrication cost (Martinez et al, 2010;Ballerini et al, 2012;Costa et al, 2014). This can be done by using hydrophilic and hydrophobic parts to control liquid regimes at an efficient cost (Zhang et al, 2013;Xue et al, 2017). This tuning of a paper surface can be easily realized by using a wax material as designed by Lee et al (2019) and Kim and Noh (2018).…”

Section: Introductionmentioning

confidence: 99%

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Testing of Beeswax Printing Technology in the Design of a Paper-Based Microfluidic System

Nunut

Whulanza²,

Kassegne

2020

IJTech

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The development of additive manufacturing technologies has the advantage of producing more economical and efficient products. This trend is supported by the fact that this technology is extensively developed, so that it has easy platforms to use, vast applications, and is more economically affordable than it was when it was first created in the early 90s. Currently, this technology is also widely applied in the bioengineering field to produce so called micro-scale products. In this study, a beeswax printer was developed by modifying a universal 3D printer to apply beeswax as a microchannel part on paper. Ultimately, this application shall be used for paper lab-on-a-chip (LOC) that enables us to perform specific functions, such as biological detection. However, a thorough study is needed to understand the limitations of this beeswax printer, along with the characterization of its product. Here, an experiment was conducted to find the optimum conditions of the system with two main parameters, namely the heating characteristics and flowability of the molten beeswax during the printing process. Additionally, an analytical model was also developed to validate the phenomena of this advanced printing media. Briefly, the beeswax printer allowed us to have a fine profile in the range of 0.5-2.0 mm wide and 30-150 µm thick. This research allowed us to find the desired profile of printed beeswax.

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Section: Introductionmentioning

confidence: 99%

“…Moreover, wax has also been used as a material in printing (Lu et al, 2009;Carrilho et al, 2009). However, further testing and characterization has yet to be applied to LOC fabrication (Xue et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Testing of Beeswax Printing Technology in the Design of a Paper-Based Microfluidic System

Nunut

Whulanza²,

Kassegne

2020

IJTech

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“…Recently, the silane coupling technology, a breakthrough for facile fabrication of µPADs, has been widely exploited to modify cellulose fibers of paper to fabricate microfluidic devices. For instance, some scholars fabricated µPADs by using trimethoxyoctadecyl‐silane (TMOS) and trimethoxysilane (TOS) separately as the silane coupling reagents to obtain hydrophobic barriers and further generate hydrophobic–hydrophilic contrasts by hydrophilic modification with paper mask penetrated with NaOH and surfactant solutions beforehand (Cai et al., 2014; Xue et al., 2017). In these works, expensive instruments, metal masks, and trained personnel were not required.…”

Section: Introductionmentioning

confidence: 99%

An ultrasimple and cost‐effective µPAD by pasting hydrophilic channels to a hydrophobic basement

et al. 2020

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The application of the paper-based microfluidic device (µPAD) as a potentially significant platform for clinical diagnoses has gained a great interest during the recent years. This work presented a technically ultrasimple, low-cost, effective, and rapid method for the µPADs fabrication by pasting a hydrophilic flower-like paper mask to a hydrophobic PVC substrate, which was purchased with adhesive on it. The whole manufacture process could be implemented in a few seconds by untrained personnel. To demonstrate the feasibility of this method in real-world situations, the developed paper device was employed for colorimetric assays of glucose in artificial urine and nitrite in artificial saliva. The main analysis parameters, for example, the optimum volumes of reagents, reaction time, and so forth, were seriatim optimized. Under optimal conditions, the detection limits were 0.9 mM and 19.5 µM for glucose and nitrite, respectively; the detection ranges were 0.9-30 mmol/L and 19.5-312.5 µmol/L for glucose and nitrite analyses, respectively. These results showed that this equipment-free µPAD had great potentials for the qualitative or semiquantitative detection of glucose and nitrite in real samples.

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PMAA-CeO2 nanoparticle-based paper microfluidic device with customized image processing software for antioxidant assay

et al. 2020

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Development of a paper-based microfluidic analytical device by a more facile hydrophobic substrate generation strategy

Cited by 9 publications

References 35 publications

Testing of Beeswax Printing Technology in the Design of a Paper-Based Microfluidic System

Testing of Beeswax Printing Technology in the Design of a Paper-Based Microfluidic System

An ultrasimple and cost‐effective µPAD by pasting hydrophilic channels to a hydrophobic basement

PMAA-CeO2 nanoparticle-based paper microfluidic device with customized image processing software for antioxidant assay

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