Hepatoprotective hemiterpene glycosides from the rhizome of Cibotium barometz (L.) J. Sm

Xie, Mei-Ping; Li, Lan; Sun, Hua; Lu, Anqi; Zhang, Bo; Shi, Jian‐Gong; Zhang, Dan; Wang, Sujuan

doi:10.1016/j.phytochem.2017.02.023

Cited by 16 publications

(6 citation statements)

References 12 publications

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“…In the clinic, Cibotium barometz was applied to degenerative diseases and inflammatory arthropathies such as osteoarthritis, osteoporosis, lumbar disc herniation, rheumatic arthritis, and ankylosing spondylitis. Relevant studies have shown that active ingredients of Cibotium barometz have various pharmacological properties, such as antioxidant, anti-inflammatory, liver-protecting, and osteoclast-suppressive effects [19,[36][37][38][39]. is study confirmed that Cibotium barometz is able to ameliorate cartilage degeneration in OA rats modelled by the Hulth method, which indicates that Cibotium barometz has a good therapeutic effect on OA.…”

Section: Discussionsupporting

confidence: 53%

Network Pharmacology-Based Strategy to Investigate the Mechanisms of Cibotium barometz in Treating Osteoarthritis

Chen

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Cibotium barometz is a representative tonifying kidney drug and is widely used for osteoarthritis (OA) in traditional Chinese medicine. However, its regulatory mechanisms in treating OA remain to be sufficiently investigated. The main chemical components of Cibotium barometz were screened through the TCMID database and the corresponding targets were acquired through SwissTargetPrediction. The OA-related targets were obtained from the OMIM, Genecards, Genebank, TTD, and DisGeNET databases. The prediction of key targets and pathways of Cibotium barometz in the treatment of OA was achieved by constructing a compounds-targets network and performing KEGG enrichment analysis. The OA model rats were established by the Hulth method and used to explore the protective effect of Cibotium barometz via cartilage pathological assessment. In vitro models of OA were built by the proinflammatory factor interleukin-1β (IL-1β) induced SW1353 cells and used to validate the mechanisms predicted by network pharmacology. Network pharmacology results suggested that the therapeutic effects of Cibotium barometz were closely related to matrix metalloproteinase (MMP)-1, 3, 13 and inflammation-related gene COX2, which are regulated by the NFκB pathway. In vivo experiments revealed that Cibotium barometz could effectively restrain cartilage from degeneration and inhibit the mRNA expression of MMP-1, MMP-3, MMP-13, and COX2 in cartilage. In vitro experiments indicated that Cibotium barometz water extract (CBWE) could significantly inhibit the expression of MMP-1, MMP-3, MMP-13, and PGE2 in IL-1β-induced SW1353 cells and markedly prevent the translocation of NFκB p65 from the cytoplasm to the nuclei and decrease its phosphorylation level. After small-interfering RNA (siRNA) was used to suppress the synthesis of NFκB p65 to block NFκB signaling pathway, the ability of CBWE to inhibit MMP-1, MMP-3, MMP-13, and PGE2 was greatly reduced. Cibotium barometz has a chondroprotective effect on OA by inhibiting the response to inflammation and substrate degradation, and the related mechanism is associated with the inhibition of the NFκB pathway.

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Section: Discussionsupporting

confidence: 53%

Network Pharmacology-Based Strategy to Investigate the Mechanisms of Cibotium barometz in Treating Osteoarthritis

Chen

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“… Erucic acid isolated from the ethanol extract improved lung injured condition by reducing CD8+ cytotoxic T lymphocyte, pro-apoptotic, hyperactivity signalling pathways and the immune inflammation Lung related complications Liang et al, 2020 Caesalpinaceae Cassia tora L. Hydroalcohol seed extract improved anxiolytic and antidepressant condition in Swiss mice model by reducing the locomotor activity and convulsion Mental Problem Shrivastava et al, 2020 Seed extract improved renal reperfusion injury in rats by reducing blood urea nitrogen and serum creatinine level and increasing the catalase, superoxide dismutase, glutathione peroxidase, antioxidant, and nitric oxide expression Kidney complications Park et al, 2019 Traditionally the leaves and seeds possess cardiotonic and cardioprotective activity Cardiac complications Awasthi et al, 2015 The plant exhibited improved lung metastasis condition in BALB/c mice bearing 26-M3.1 colon carcinoma cell tumours Lung related complications Zhao et al, 2013 Ethanol seed extract reduced plasma lipid levels, hepatic lipid accumulation and improved hepatic histological lesions by enhancing the phosphorylation of AMP-activated protein kinase enzyme in high fat diet treated rat Liver related problem Tzeng et al, 2013 Petroleum ether, methanol and ethyl acetate extract improved in oxotremorine treated mice Parkinsonism Suryawanshi et al, 2009 Celastraceae Tripterygium regelii Sprague Methanol extract of leaves may prevent Parkinson's disease by increasing Bax, tyrosine hydroxylase, caspase-3, caspase-9 level, brain-derived neurotrophic factor and by decreasing Bcl-2 in SH-SY5Y cells Parkinsonism Choi et al, 2010 Cibotiaceae Cibotium barometz (L.) J. Sm. Hemiterpene glycosides isolated from hydroalcohol extract of rhizome showed hepatoprotective activity against acetaminophen induced HepG2 cell death Liver related problem Xie et al, 2017 Compositae Chrysanthemum indicum L. Ethanol flower extract showed cardio-protective activity by inhibiting atherosclerosis and decreased serum lipid level in high fat diet treated rats Cardiac comp...…”

Section: Herbal Formulae From Different Traditional Systems Of Medicinementioning

confidence: 99%

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

et al. 2022

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Background : The worldwide corona virus disease outbreak, generally known as COVID-19 pandemic outbreak resulted in a major health crisis globally. The morbidity and transmission modality of COVID-19 appear more severe and uncontrollable. The respiratory failure and following cardiovascular complications are the main pathophysiology of this deadly disease. Several therapeutic strategies are put forward for the development of safe and effective treatment against SARS-CoV-2 virus from the pharmacological view point but till date there are no specific treatment regimen developed for this viral infection. Purpose : The present review emphasizes the role of herbs and herbs-derived secondary metabolites in inhibiting SARS-CoV-2 virus and also for the management of post-COVID-19 related complications. This approach will foster and ensure the safeguards of using medicinal plant resources to support the healthcare system. Plant-derived phytochemicals have already been reported to prevent the viral infection and to overcome the post-COVID complications like parkinsonism, kidney and heart failure, liver and lungs injury and mental problems. In this review, we explored mechanistic approaches of herbal medicines and their phytocomponenets as antiviral and post-COVID complications by modulating the immunological and inflammatory states. Study design : Studies related to diagnosis and treatment guidelines issued for COVID-19 by different traditional system of medicine were included. The information was gathered from pharmacological or non-pharmacological interventions approaches. The gathered information sorted based on therapeutic application of herbs and their components against SARSCoV-2 and COVID-19 related complications. Methods : A systemic search of published literature was conducted from 2003 to 2021 using different literature database like Google Scholar, PubMed, Science Direct, Scopus and Web of Science to emphasize relevant articles on medicinal plants against SARS-CoV-2 viral infection and Post-COVID related complications. Results : Collected published literature from 2003 onwards yielded with total 625 articles, from more than 18 countries. Among these 625 articles, more than 95 medicinal plants and 25 active phytomolecules belong to 48 plant families. Reports on the therapeutic activity of the medicinal plants belong to the Lamiaceae family (11 reports), which was found to be maximum reported from 4 different countries including India, China, Australia, and Morocco. Other reports on the medicinal plant of Asteraceae (7 reports), Fabaceae (8 reports), Piperaceae (3 reports), Zingiberaceae (3 reports), Ranunculaceae (3 reports), Meliaceae (4 reports) were found, which can be explored for the development of safe and efficacious products targeting COVID-19. Conclusion : K...

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“…Autocorrelated data can be addressed by fitting models to the data and analyzing the residuals, instead of the variables. With ARIMA models, crosscorrelation between the variables is not accounted for, and although multivariate models can also be employed using this approach, it becomes a complex task when there are many variables (m > 10), owing to the high number of parameters that must be estimated, as well as the presence of crosscorrelation [3,59].…”

Section: Supervised Feature Extraction 31 Autoregressive Modelsmentioning

confidence: 99%

Process Fault Diagnosis for Continuous Dynamic Systems Over Multivariate Time Series

Aldrich¹

2019

Time Series Analysis - Data, Methods, and Applications

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Fault diagnosis in continuous dynamic systems can be challenging, since the variables in these systems are typically characterized by autocorrelation, as well as time variant parameters, such as mean vectors, covariance matrices, and higher order statistics, which are not handled well by methods designed for steady state systems. In dynamic systems, steady state approaches are extended to deal with these problems, essentially through feature extraction designed to capture the process dynamics from the time series. In this chapter, recent advances in feature extraction from signals or multivariate time series are reviewed. These methods can subsequently be considered in a classical statistical monitoring framework, such as used for steady state systems. In addition, an extension of nonlinear signal processing based on the use of unthresholded or global recurrence quantification analysis is discussed, where two multivariate image methods based on gray level co-occurrence matrices and local binary patterns are used to extract features from time series. When considering the well-known simulated Tennessee Eastman process in chemical engineering, it is shown that time series features obtained with this approach can be an effective means of discriminating between different fault conditions in the system. The approach provides a general framework that can be extended in multiple ways to time series analysis.

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Hepatoprotective hemiterpene glycosides from the rhizome of Cibotium barometz (L.) J. Sm

Cited by 16 publications

References 12 publications

Network Pharmacology-Based Strategy to Investigate the Mechanisms of Cibotium barometz in Treating Osteoarthritis

Network Pharmacology-Based Strategy to Investigate the Mechanisms of Cibotium barometz in Treating Osteoarthritis

Role of medicinal plants in inhibiting SARS-CoV-2 and in the management of post-COVID-19 complications

Process Fault Diagnosis for Continuous Dynamic Systems Over Multivariate Time Series

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