2017
DOI: 10.1016/j.actatropica.2017.02.032
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Antibodies elicited during natural infection in a predominantly Plasmodium falciparum transmission area cross-react with sexual stage-specific antigen in P. vivax

Abstract: Infections caused by Plasmodium falciparum and P. vivax account for more than 90% of global malaria burden. Exposure to malaria parasite elicits immune responses during natural infection and it is generally believed that the immunity is not only stage specific but also species specific. However, partial genomic similarity for various antigens in different Plasmodium spp. raises the possibility of immunological cross-reactivity at the level of specific antigens. Serum samples collected from children who were pe… Show more

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Cited by 13 publications
(9 citation statements)
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References 31 publications
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“…However, the presence of submicroscopic infections or the presence of residual antibodies from a previous infection(s) could not be ruled out by those authors. Similarly, there is a strong indication of the presence of cross-reactive responses to other sexual (17) and asexual (3,16,18) blood-stage antigens from the field. However, the data cannot be exclusively attributed to cross-reaction, as the presence of heterologous species, while rare, has not been ruled out.…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…However, the presence of submicroscopic infections or the presence of residual antibodies from a previous infection(s) could not be ruled out by those authors. Similarly, there is a strong indication of the presence of cross-reactive responses to other sexual (17) and asexual (3,16,18) blood-stage antigens from the field. However, the data cannot be exclusively attributed to cross-reaction, as the presence of heterologous species, while rare, has not been ruled out.…”
Section: Resultsmentioning
confidence: 99%
“…Despite the presence of orthologous antigens, few studies have evaluated the presence of cross-reactive antibodies. Sera from regions with a predominance of one species, but not a total absence of the other species, have been shown to have cross-reactivity to some antigens, such as merozoite surface protein 1 (MSP-1) (15), MSP-5 (16), P. falciparum s48/45 (Pfs48/45) or P. vivax s48/45 (Pvs48/45) (17), and PfCLAG9 (18). Using P. falciparum and P. vivax protein microarrays, King and colleagues (3) observed cross-reactivity using sera from "essentially monoexposed" regions of endemicity.…”
mentioning
confidence: 99%
“…Genomic DNA for the molecular diagnosis of asymptomatic P. falciparum and genotyping was extracted from whole blood using the Qiagen FlexiGene DNA Kit following the manufacturer’s protocol. A nested PCR protocol was used for molecular diagnosis of sub‐microscopic asymptomatic P. falciparum infections [30, 31].…”
Section: Methodsmentioning
confidence: 99%
“…To the best of our knowledge, only the gametocyte antigen P48/45 has emerged as a candidate for cross-species recognition. Sera from school-aged children living in a P. falciparum endemic area of Zimbabwe were highly cross-reactive to the P. vivax homolog Pvs48/45 (76). Thirtysix of 49 (73%) samples positive for Pfs48/45 by ELISA also recognized Pvs48/45.…”
Section: Transmission-blocking Targetsmentioning
confidence: 99%