Corrigendum to “CXCL1-Mediated Interaction of Cancer Cells with Tumor-Associated Macrophages and Cancer-Associated Fibroblasts Promotes Tumor Progression in Human Bladder Cancer” [Neoplasia 18 (2016) 636–646]

Miyake, Makito; Morizawa, Yosuke; Tatsumi, Yoshihiro; Nakai, Yasushi; Anai, Satoshi; Torimoto, Kazumasa; Aoki, Katsuya; Tanaka, Nobumichi; Shimada, Kaoru; Konishi, Noboru; Toritsuka, Michihiro; Kishimoto, Toshifumi; Rosser, Charles J.; Fujimoto, Kiyohide

doi:10.1016/j.neo.2016.12.012

Cited by 3 publications

(1 citation statement)

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“…The dysfunction and exhaustion of cytotoxic T cells contribute to the immune related tolerance and immunosuppression during the progression of cancers. On the other hand, high infiltration of macrophages and cancer-associated fibroblasts has been evidenced to have been associated with the tumor progression and poor outcomes of patients [ 28 – 31 ]. The further analysis of immune checkpoints in this study revealed that the expressions of protective factors such as TNFRSF4, CD27, TNFRSF25, PDCD1, TNFRSF14, CD40, and TIGIT were significantly lower in the high-risk group, while expressions of cancer promotors such as PDCD1LG2, TNFSF9, NRP1, CD276, and CD44 were significantly higher in this group, also suggesting that the high-risk group has poor overall survival [ 32 – 35 ].…”

Section: Discussionmentioning

confidence: 99%

A New Prognostic Signature Constructed with Necroptosis-Related lncRNA in Bladder Cancer

Lü

Gao

et al. 2022

Journal of Oncology

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Background. Bladder cancer (BC) accounts for the most common urologic malignancy, leading to a heavy social burden over the world. We aim to search for a novel prognostic biomarker with necroptosis-related lncRNAs of bladder cancer in this study. Methods. We download the RNA-sequencing data and corresponding clinical information of BC patients from TCGA. We performed Pearson correlation analysis to identify necroptosis-related lncRNAs (NRlncRNAs). Then, we used univariate Cox regression, Lasso Cox analysis, and multivariate Cox regression to construct the optimal prognostic model. Next, we used Kaplan–Meier curves, Cox regression, receiver operating characteristic (ROC) curves, nomogram, and stratified survival analysis to evaluate the capacity of the prognostic signature. Furthermore, gene set enrichments in the signature and the correlation between prognostic signature and necroptosis genes, tumor microenvironment, immune infiltration, and immune checkpoints of BC were also explored. Results. A 7-NRlncRNAs signature comprising FKBP14-AS1, AL731567.1, LINC02178, AC011503.2, LINC02195, AC068196.1, and AL136084.2 was constructed to predict the prognosis of BC in this research. Cox regression analysis showed that the signature could be an independent prognostic factor for BC patients ( P < 0.001 ). Compared to other clinicopathological characteristics, this signature displayed a better capacity of prediction with the area under the curve (AUC) of 0.745. Stratified analysis using various clinical variables demonstrated that the prognostic signature has good clinical fitness. GSEA showed that focal adhesion and the WNT signaling pathway were enriched in the high-risk group. Immune infiltration analysis indicated that the signature was significantly inversely correlated with infiltration of CD8+ T cells and CD4+ T cells while positively correlated with macrophages and cancer associated fibroblasts. Immune checkpoint analysis revealed that the expressions of protective factors were significantly lower in the high-risk group, while expressions of cancer promotors were significantly higher in this group. The gene expression analysis displayed that necroptosis genes such as FADD, FAS, MYC, STAT3, PLK1, LEF1, EGFR, RIPK3, CASP8, BRAF, ID1, GATA3, MYCN, CD40, and TNFRSF21 were significantly different between the two groups. Conclusions. The 7-NRlncRNAs signature can predict the overall survival of BC and may provide help for the individualized treatment of BC patients.

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Section: Discussionmentioning

confidence: 99%

A New Prognostic Signature Constructed with Necroptosis-Related lncRNA in Bladder Cancer

Lü

Gao

et al. 2022

Journal of Oncology

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Modulation of the antitumor immune response by cancer-associated fibroblasts: mechanisms and targeting strategies to hamper their immunosuppressive functions

Thiery

2022

Exploration of Targeted Anti-Tumor Therapy

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Cancer-associated fibroblasts (CAFs) are highly heterogeneous players that shape the tumor microenvironment and influence tumor progression, metastasis formation, and response to conventional therapies. During the past years, some CAFs subsets have also been involved in the modulation of immune cell functions, affecting the efficacy of both innate and adaptive anti-tumor immune responses. Consequently, the implication of these stromal cells in the response to immunotherapeutic strategies raised major concerns. In this review, current knowledge of CAFs origins and heterogeneity in the tumor stroma, as well as their effects on several immune cell populations that explain their immunosuppressive capabilities are summarized. The current development of therapeutic strategies for targeting this population and their implication in the field of cancer immunotherapy is also highlighted.

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The Effect of Immunological Biomarkers - Nlr, Plr, Lmr, Pd-L1 on the Survival of Patients With Muscle-Invasive Bladder Cancer

Gorelov,

Zhuravsky,

Gorelova

et al. 2024

Themed Collection of Papers From Foreign International Scientific Conference «Modern Research on the Way to a New Scientific Re

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Bladder cancer is a heterogeneous group of tumor lesions of the bladder, mainly represented by two types of malignant epithelial tumors - muscle-invasive urothelial bladder cancer (MIUBC) and non-muscle-invasive urothelial bladder cancer (NMIUBC). Due to the different molecular genetic profile of various types of urothelial carcinomas (the development of NMIUBC occurs mainly along the path of activation of oncogenes (FGFR3, RAS kinase genes), and the development of MIUBC along the path of damage to chromatin remodeling genes, inactivation of suppressor genes (TP53, RB1, PTEN), bladder cancer is an attractive model for studies of molecular and immunological biomarkers. As part of the first stage of the study, the prognostic value of perioperative immunological markers LMR (Lymphocyte-monocyte ratio), PLR (platelet-lymphocyte ratio) and NLR (neutrophil-lymphocyte ratio) was evaluated in patients with muscle-invasive bladder cancer who underwent radical cystectomy (RC). A retrospective study included 100 patients with MIUBC who underwent RC between 1995 and 2013. The endpoints of the study were overall survival (OS) [1].

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Corrigendum to “CXCL1-Mediated Interaction of Cancer Cells with Tumor-Associated Macrophages and Cancer-Associated Fibroblasts Promotes Tumor Progression in Human Bladder Cancer” [Neoplasia 18 (2016) 636–646]

Cited by 3 publications

References 0 publications

A New Prognostic Signature Constructed with Necroptosis-Related lncRNA in Bladder Cancer

A New Prognostic Signature Constructed with Necroptosis-Related lncRNA in Bladder Cancer

Modulation of the antitumor immune response by cancer-associated fibroblasts: mechanisms and targeting strategies to hamper their immunosuppressive functions

The Effect of Immunological Biomarkers - Nlr, Plr, Lmr, Pd-L1 on the Survival of Patients With Muscle-Invasive Bladder Cancer

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