Erratum: Colorectal carcinomas with submucosal invasion (pT1): analysis of histopathologic and molecular factors predicting lymph node metastasis

Abstract

CorrigendumColorectal carcinomas with submucosal invasion (pT1): analysis of histopathologic and molecular factors predicting lymph node metastasis

Combined histopathological risk score using TP53 protein expression, CD8+ T cell density and intratumoral budding is an independent predictor of neoadjuvant therapy response in rectal adenocarcinoma

“…Mutations in TP53 have been associated with epithelial-mesenchymal transition in colorectal cancer. [23][24][25] In our study, we did not identify a significant association between the presence of ITB and TP53 expression by immunohistochemistry in biopsies of rectal adenocarcinoma. Additional study of the relationship of ITB and TP53 molecular alterations is needed to determine the association, if any, between these two features in rectal cancer.…”

Histologic Evaluation of Malignant Polyps and Low-Stage Colorectal Carcinoma

“…26,27 Using this system, intermediate to high budding is associated with lymph node metastasis in pT1 cancers and high tumor budding is associated with an increased risk of recurrence and mortality in stage II cancers (Figure 3, D). 1,10,11,[19][20][21]39 Caution must be taken in assessing tumor buds in certain histologic variants of CRC. Clusters of cells suspended in pools of mucin should not be counted as tumor buds in mucinous and signet-ring cell carcinomas.…”

Interobserver Variability in Assessment of Depth of Submucosal Invasion for Colonic Endoscopic Resections Among Subspecialized Gastrointestinal Pathologists

“…These authors also reported that depth of submucosal invasion 1000 lm or more was significantly more common among lymph node-positive compared with lymph node-negative tumors (81% versus 60%, P ¼ .04). 11 However, the literature has been divided on the cutoff for submucosal depth, with some other studies proposing 2000 lm as a more reasonable cutoff. 6,7 Nonetheless, pathologists are now increasingly being expected to include the depth of submucosal invasion in their pathology reports.…”

“…Measuring from the surface, although the most objective and reproducible method in our study, results in most measurements exceeding 1000 lm and would likely result in overtreatment with associated morbidity in a substantial proportion of patients. Although most papers that correlated depth of invasion with nodal metastases do state the recommended guidelines, 11,18 details about intraobserver reproducibility and numbers of pathologists performing the assessments are generally lacking. Indeed, varying recommendations for the cutoff of submucosal depth of invasion for endoscopic management of pT1 colonic adenocarcinomas may, in part, reflect different standards and methods used to measure the depth itself.…”

“…[1][2][3][4][5] The pathologic criteria for cure of an endoscopically resected pT1 colonic adenocarcinoma include clear margins, along with low-grade histologic features, that is, lack of high-grade morphology or tumor budding, and no lymphovascular invasion. 3,[5][6][7][8][9][10][11][12][13][14][15][16] Recently, it has been suggested that, in the absence of the aforementioned features, depth of submucosal invasion 1000 lm or more may be an indication for colectomy whereas tumors that invade less than 1000 lm can be managed conservatively with surveillance. 17 The project study by the Japanese Society for Cancer of the Colon and Rectum (JSCCR) reported that nodal metastases occurred in 12.5% of CRCs with a submucosal depth of invasion 1000 lm or greater.…”