Steroids and Autoimmunity

Trombetta, A.C.; Meroni, M.; Cutolo, Maurizio

doi:10.1159/000452911

Cited by 30 publications

(18 citation statements)

References 58 publications

(52 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study in pediatrics, the gender difference is not evident, but we noted the importance of pubertal stages given the higher prevalence in pubertal compared to prepubertal subjects. These results may confirm that exposure to hormonal changes during puberty plays a fundamental role in immune function (5,7,17,(28)(29)(30) and consequently in the development of ATD. In our population this is not gender specific, supporting that factors other than hormones, such as environmental effects, could influence the effect of puberty on the disease state (7).…”

Section: Discussionsupporting

confidence: 67%

Gender Differences at the Onset of Autoimmune Thyroid Diseases in Children and Adolescents

et al. 2020

View full text Add to dashboard Cite

Background: The incidence of autoimmune thyroid diseases (ATD) may vary with the beginning of reproductive function, although few reports differentiate the incidence before and during the onset of puberty, examining gender bias. We analyzed onset of ATD in a pediatric population to assess gender differences in onset age, disease subtype, pubertal status, autoimmune co-morbidity, family history and treatment, focusing on the interaction between gender and pubertal stage. Patients and methods: We retrospectively recorded 382 children and adolescents with ATD. In each patient physical examination was considered. The presence of other associated autoimmune diseases (AAD) and familial predisposition was also recorded. Results: Predominant prevalence was noted in females compared to males (p < 0.001), both in Hashimoto's diseases (HD or HT) and Graves' disease (GD) (p < 0.001). Mean age at diagnosis showed no significant difference between sexes (p > 0.05). A higher prevalence in pubertal subjects was noted compared to prepubertal (p < 0.001, particularly HT in early and GD in late pubertal stage), without sexes difference intra-(prepubertal vs. pubertal) and inter-puberty groups (prepubertal vs. early pubertal vs. late pubertal). Both in HT and in GD, the prevalence of autoimmune associated diseases (AAD) was higher in males compared to females (p = 0.04), with similar distribution according to the pubertal maturation. The familial predisposition was similarly distributed in both genders (p > 0.05) and into pubertal stages (p > 0.05). Conclusions: Females are more prone to develop ATD during puberty, earlier in HT than in GD. The effect of puberty is not different between genders, suggesting the role of additional factors other than hormones. The screening for detection of ATD is recommended in all patients with positive family history and other autoimmune diseases, mostly in males. Considerations of gender in pediatrics could be important to define pathogenic mechanisms of ATD and to help in early diagnosis and clinical management.

show abstract

Section: Discussionsupporting

confidence: 67%

Gender Differences at the Onset of Autoimmune Thyroid Diseases in Children and Adolescents

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Endocrine and immune systems influence each other in a bidirectional fashion [36]. In fact, adrenal and sex hormones, as well as vitamin D, melatonin, and prolactin contribute importantly to the homeostasis of the immune system.…”

Section: Discussionmentioning

confidence: 99%

Autoimmune Diseases in Patients with Cushing’s Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review

Petramala

Olmati

Conforti

et al. 2018

International Journal of Endocrinology

View full text Add to dashboard Cite

Introduction Cushing's syndrome (CS) is a clinical condition characterized by excessive cortisol production, associated with metabolic complications, such as diabetes mellitus, dyslipidemia, metabolic syndrome, hypertension, and cardiovascular diseases. Nowadays, the occurrence of autoimmune diseases in CS have not been completely evaluated in the previous studies. Objective The aim of this study was to evaluate the occurrence of autoimmune diseases in CS patients after successfully treated. Materials and Methods From January 2001 to December 2017, in our Secondary Hypertension Unit, we evaluated 147 CS patients (91 with ACTH-independent disease, 54 with ACTH-dependent disease, and 2 patients with ectopic ACTH production. Results 109 CS patients (74.1%) were surgically treated (67 ACTH-independent CS patients (61.5%) undergone adrenalectomy and 42 ACTH-dependent CS (38.5%) undergone transsphenoidal surgery) and evaluated after 6, 12, and 24 months after clinical and biochemical remission of disease. In 9 (8.3%) of overall treated CS patients (8.3%), during follow-up, we observed the onset of some manifestations of autoimmune diseases. In particular, one patient had a systemic lupus erythematosus, one patient had rheumatoid arthritis, 4 patients reported autoimmune thyroiditis (Basedow-Graves' disease and Hashimoto's thyroiditis), one patient had clinical features of psoriasis, one patient showed myasthenia gravis, and one patient had giant cell arteritis. Conclusions Our results demonstrate that patients successfully treated for CS could develop autoimmune diseases. Therefore, after treatment, CS patients need to be strictly monitored in order to evaluate the possible onset of autoimmune diseases.

show abstract

“…Glucocorticoids as immunomodulatory agents have been applied to treat allergic and chronic inflammatory diseases, such as asthma, dermatitis and rheumatoid arthritis since the 1950s (31,32). Several recent RCTs showed that a combination of glucocorticoids and conventional treatment was superior to conventional monotherapy (33)(34)(35)(36); however, other reports claimed that mono-therapies and combination therapy had similar results (37).…”

Section: Discussionmentioning

confidence: 99%

The Efficacy and Safety of Glucocorticoids Plus Conventional Therapy for Hepatitis B-Related Liver Failure in China: A Meta-Analysis

et al. 2019

View full text Add to dashboard Cite

The aim of this meta-analysis was to evaluate the efficacy and safety of glucocorticoid plus conventional therapy in hepatitis B-related liver failure. Evidence Acquisition: A systematic search was performed in PubMed, Embase, the Cochrane library, China National Knowledge Infrastructure, Wanfang database, and Google Scholar. The primary outcome was improvement in the mortality rate and the secondary outcome was the incidence of complications. Pooled data were based on the fixed-effect model. Results: Ten studies with 891 patients were included in the meta-analysis. Glucocorticoid plus conventional therapy (OR = 3.98, 95%

show abstract

Steroids and Autoimmunity

Cited by 30 publications

References 58 publications

Gender Differences at the Onset of Autoimmune Thyroid Diseases in Children and Adolescents

Gender Differences at the Onset of Autoimmune Thyroid Diseases in Children and Adolescents

Autoimmune Diseases in Patients with Cushing’s Syndrome after Resolution of Hypercortisolism: Case Reports and Literature Review

The Efficacy and Safety of Glucocorticoids Plus Conventional Therapy for Hepatitis B-Related Liver Failure in China: A Meta-Analysis

Contact Info

Product

Resources

About