Sivelestat sodium and mortality in pneumonia patients requiring mechanical ventilation: propensity score analysis of a Japanese nationwide database

Kishimoto, Miwa; Yamana, Hayato; Inoue, Satoki; Noda, Tatsuya; Myojin, Tomoya; Matsui, Hiroki; Yasunaga, Hideo; Kawaguchi, Masahiko; Imamura, Tomoaki

doi:10.1007/s00540-017-2327-1

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…On day 40, lungs were isolated and used for protein analysis by immunohistological staining. The efficacy of β-arrestin knockdown in the progression of pneumonia was determined by PSI score of pneumonia mice ( 35 ).…”

Section: Methodsmentioning

confidence: 99%

Antibiotic resistance of Klebsiellaï¿½pneumoniae through β-arrestin recruitment-induced β-lactamase signaling pathway

et al. 2018

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Overuse and misuse of antibiotics leads to rapid evolution of antibiotic-resistant bacteria and antibiotic resistance genes. Klebsiella pneumoniae has become the most common pathogenic bacterium accountable for nosocomial infections due to its high virulence factor and general occurrence of resistance to most antibiotics. The β-lactamase signaling pathway has been suggested to be involved in antibiotic resistance against β-lactams in Klebsiella pneumoniae. In the present study, the molecular mechanism of the antibiotic resistance of Klebsiella pneumoniae was investigated and the results indicated involvement of the β-arrestin recruitment-induced β-lactamase signaling pathway. Antimicrobial susceptibility of Klebsiella pneumoniae was assessed using automated systems and extended-spectrum β-lactamase (ESBL) and β-arrestin expression levels in Klebsiella pneumoniae were analyzed by reverse-transcription quantitative PCR. β-lactam resistance in Klebsiella pneumoniae was determined using β-lactam agar screening plates. The results demonstrated that β-arrestin recruitment was increased in Klebsiella pneumoniae with antibiotic resistance (AR-K.P.) compared with that in the native Klebsiella pneumoniae strain (NB-K.P.). Increased production of ESBL was observed in AR-K.P. after treatment with the β-lactam penicillin. Of note, inhibition of β-arrestin recruitment significantly suppressed ESBL expression in AR-K.P. and in addition, genes encoding β-arrestin and ESBL were upregulated in Klebsiella pneumoniae. Restoration of endogenous β-arrestin markedly increased antibiotic resistance of Klebsiella pneumoniae to β-lactam. Knockdown of endogenous β-arrestin downregulated antibiotic resistance genes and promoted the inhibitory effects of β-lactam antibiotic treatment on Klebsiella pneumoniae growth. In conclusion, the present study identified that β-arrestin recruitment was associated with growth and resistance to β-lactams, which suggested that β-arrestin regulating ESBL expression may be a potential target for addressing antibiotic resistance to β-lactams in Klebsiella pneumoniae.

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Section: Methodsmentioning

confidence: 99%

Antibiotic resistance of Klebsiellaï¿½pneumoniae through β-arrestin recruitment-induced β-lactamase signaling pathway

et al. 2018

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“…, b |B| . Every patient p ∈ D has a s-dimensional covariate vector cv(p), describing the patients condition, and an observed value o(p), describing the result of the therapy, for examples see (Abidov et al, 2005;Adams et al, 2017;Burden et al, 2017;Capucci et al, 2017;Chen et al, 2016;Cho et al, 2017;Dou et al, 2017;Fukami et al, 2017;Gozalo et al, 2015;Kishimoto et al, 2017;Kong et al, 2017;Lai et al, 2016;Lee et al, 2017;Liu et al, 2016;McDonald et al, 2017;McEvoy et al, 2016;Ray et al, 2012;Salati et al, 2017;Schermerhorn et al, 2008;Seung et al, 2008;Shaw et al, 2008;Svanström et al, 2013;Tranchart et al, 2016;Zangbar et al, 2016;Zhang et al, 2016Zhang et al, , 2015.…”

Section: Introductionmentioning

confidence: 99%

A deterministic matching method for exact matchings to compare the outcome of different interventions

Bestehorn,

Kirches

2021

Preprint

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Statistical matching methods are widely used in the social and health sciences to estimate causal effects using observational data. Often the objective is to find comparable groups with similar covariate distributions in a dataset, with the aim to reduce bias in a random experiment. We aim to develop a foundation for deterministic methods which provide results with low bias, while retaining interpretability. The proposed method matches on the covariates and calculates all possible maximal exact matches for a given dataset without adding numerical errors. Notable advantages of our method over existing matching algorithms are that all available information for exact matches is used, no additional bias is introduced, it can be combined with other matching methods for inexact matching to reduce pruning and that the result is calculated in a fast and deterministic way. For a given dataset the result is therefore provably unique for exact matches in the mathematical sense. We provide proofs, instructions for implementation as well as a numerical example calculated for comparison on a complete survey.

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“…High dose steroid administration was associated with a worse outcome in a study using a large administrative database [8]. Similarly, Sivelestat sodium hydrate, a leukocyte elastase inhibitor, failed to improve the outcome for patients with pneumonia [9].…”

mentioning

confidence: 99%

Post-surgical immune suppression: another target to improve postoperative outcomes

Uchida

2019

J Anesth

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Sivelestat sodium and mortality in pneumonia patients requiring mechanical ventilation: propensity score analysis of a Japanese nationwide database

Abstract: The propensity-matched analyses revealed that the use of sivelestat was not associated with decreased mortality for pneumonia patients requiring mechanical ventilation.

Cited by 4 publications

References 25 publications

Antibiotic resistance of Klebsiellaï¿½pneumoniae through β-arrestin recruitment-induced β-lactamase signaling pathway

Antibiotic resistance of Klebsiellaï¿½pneumoniae through β-arrestin recruitment-induced β-lactamase signaling pathway

A deterministic matching method for exact matchings to compare the outcome of different interventions

Post-surgical immune suppression: another target to improve postoperative outcomes

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