The effects of co-administration of pregabalin and vitamin E on neuropathic pain induced by partial sciatic nerve ligation in male rats

Meymandi, Manzumeh Shamsi; Sepehri, Gholamreza; Abdolsamadi, Mona; Shaabani, Mohammad; Heravi, Gioia; Yazdanpanah, Omid; Aghtaei, Mohammadmehdi-Moeini

doi:10.1007/s10787-017-0325-4

Cited by 19 publications

(9 citation statements)

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“…To date, there is no published evidence about the antiallodynic interaction between pregabalin + thioctic acid, but a clinical trial has been registered to compare both drugs alone, or in combination, in the treatment of several pathologies of neuropathic pain in subjects (Gilron et al, ). Our data about the antiallodynic effect of pregabalin + α‐tocopherol combination agrees with a study performed in rats submitted to partial sciatic nerve‐ligation that indicates that tocotrienol shows a tendency to increase slightly the antineuropathic effect of pregabalin (Meymandi et al, ). Likewise, they are in line with a randomized controlled clinical trial, where vitamin E seems to improve the total pain score of diabetic patients treated with pregabalin and hypoglycemic agents (Rajanandh et al, ).…”

Section: Discussionsupporting

confidence: 92%

Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats

Cruz-Álvarez

Zúñiga-Romero

Huerta-Cruz

et al. 2018

Drug Development Research

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Painful peripheral neuropathy can be associated with nerve damage caused by diabetes mellitus. Although pregabalin is the first‐line therapy for peripheral neuropathy, it shows substantial discontinuation rates, mainly because of nervous system side effects as motor incoordination. Multimodal therapy may improve the motor side effect profile of pregabalin. The aim of this study was to evaluate the interaction of pregabalin + thioctic acid or pregabalin + α‐tocopherol on allodynia and motor performance in neonatal streptozotocin‐induced diabetic rats. Efficacy of drugs separately or in combination was tested by tactile allodynia using von Frey filaments. Isobolographic and interaction index analysis were used to determine the antiallodynic interaction between pregabalin and either thioctic acid or α‐tocopherol. Motor performance was measured using a rotarod test. Pregabalin, thioctic acid, and α‐tocopherol reduced, in a dose‐dependent fashion, tactile allodynia. Pregabalin + thioctic acid and pregabalin + α‐tocopherol combinations also dose‐dependently reduced allodynic behavior in diabetic rats. Isobolographic analysis revealed an additive interaction for both combinations. Consistently, the interaction indices confirmed the additive effect between pregabalin + thioctic acid and pregabalin + α‐tocopherol. In addition, the administration of either combination improved motor incoordination induced by pregabalin. Data suggests that thioctic acid or α‐tocopherol could positively impact the therapeutic profile of pregabalin, because they might be useful for reducing motor incoordination associated to pregabalin in patients with peripheral neuropathy.

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Section: Discussionsupporting

confidence: 92%

Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats

Cruz-Álvarez

Zúñiga-Romero

Huerta-Cruz

et al. 2018

Drug Development Research

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“…PGB pretreatment of VPA‐induced autism‐like symptoms increased TDM and speed similar to control values. In several studies, it was shown that PGB did not affect motor activity (Meymandi, Sepehri, et al, 2017; Zimcikova, Simko, Karesova, Kremlacek, & Malakova, 2017), on the contrary, neuroprotective effect of PGB may contribute in the improvement of motor activity in all prenatally exposed PGB groups (Salat et al., 2016; Shamsi Meymandi et al., 2018). However, a recent study reported that PGB at high doses of 600 mg/kg might produce defect in chick embryos (Sayin & Simsek, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…PGB treatment during gestational period was associated with beneficial effects on distorted pain sensitivity in prenatally VPA exposed rats, that is, low dose of PGB treatment (15 mg/kg) during gestational period in prenatally VPA‐treated rats significantly decreased the threshold to pain stimuli (in tail flick) compared to VPA group. In fact, PGB showed antinociceptive effect in different animal models of acute and chronic pain in normal rats (Meymandi & Keyhanfar, 2012; Meymandi, Keyhanfar, Sepehri, Heravi, & Yazdanpanah, 2017; Meymandi, Keyhanfar, Yazdanpanah, & Heravi, 2015; Meymandi, Sepehri, et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

“…was injected once at 12.5 gestational days for autism‐like induction in newborn rats (Schneider & Przewłocki, 2005). PGB doses were selected based on effective dose in neuropathy and epilepsy in experimental animal studies (Ali et al., 2019; Meymandi, Sepehri, et al, 2017; Vartanian et al., 2006). Control pregnant females received normal saline during the same periods.…”

Section: Methodsmentioning

confidence: 99%

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Prenatal pregabalin is associated with sex‐dependent alterations in some behavioral parameters in valproic acid‐induced autism in rat offspring

Meymandi

Sepehri

Moslemizadeh

et al. 2020

Intl J of Devlp Neuroscience

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This study was performed to evaluate the effects of prenatal exposure to pregabalin (PGB) on behavioral changes of rat offspring in an animal model of valproic acid (VPA)-induced autism-like symptoms. Pregnant rats received VPA (600 mg/kg/i.p.) once at 12.5 gestational days for autism-like symptom induction in offspring. After the delivery single male and single female offspring from each mother were randomly selected for behavioral test (anxiety, pain response, pleasure, and motor function) at 60th day adulthood (n = 7). Offspring received prenatal PGB (15 & 30 mg/kg/i.p.) during gestational days 9.5 to 15.5 either alone or in combination with VPA (PGB15, PGB30, PGB15 + VPA, and PGB30 + VPA). Control offspring received normal saline during the same period. The result showed that prenatal VPA exposure was associated with autism-like behaviors in rat offspring. PGB treatment during the gestational period revealed significant reduction in sucrose preference test and anxiety in elevated plus maze and open field test in offspring. Also, PGB treatments exhibited a dose-dependent increase in pain threshold in prenatally VPA exposed rats in tail-flick and hot plate test. Also, there was a sex-related significant impairment in motor function in beam balance and open field test, and male rats were affected more than females. However, no significant sex differences in sucrose preference and pain sensitivity were observed in prenatal PGB-treated rat offspring. In conclusion, prenatal exposure to VPA increased the risk of autism-like behaviors in the offspring rats, and PGB treatment during the gestational period was associated with some beneficial effects, including anxiety reduction and motor impairment in autism-like symptoms in rat offspring. K E Y W O R D S anhedonia, anxiety, autism, pain, pregabalin, valproic acid | 501 SHAMSI MEYMANDI Et Al. 1 | INTRODUCTION Autism spectrum disorder (ASD) is a complicated, behaviorally defined disorder, including communication and social interaction deficits and restricted, repetitive and stereotyped behaviors (Bolte et al., 2019). Prevalence estimates and diagnosis rates of ASD have risen substantially in the last two decades reaching 1.5% in developed countries (Lyall et al., 2017). According to the World Health Organization (WHO) report in 2018, 1 in 160 children had ASD. In most of cases, ASD is associated with epilepsy, since different studies showed that 22% to 38% of children with autism also suffer from comorbid epilepsy (

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“…Vit E, a free scavenger, reduces oxidative‐nitrosative stress 12 . It has been reported to reduce hyperalgesia and allodynia effects of NP 13‐15 via its antioxidant and anti‐inflammatory properties 12,16 . LiCl, a common bipolar disorder drug, possesses anti‐allodynic and anti‐hyperalgesic properties against various models of NP 17‐19 .…”

Section: Introductionmentioning

confidence: 99%

Effects of co‐administration of vitamin E and lithium chloride on chronic constriction injury‐induced neuropathy in male Wistar rats: Focus on antioxidant and anti‐inflammatory mechanisms

2021

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Objectives This study investigated the antinociceptive effects of co‐administration of lithium chloride (LiCl) and vitamin E (Vit E) on chronic constriction injury (CCI)‐induced peripheral neuropathy in male Wistar rats. It further explored the anti‐inflammatory and neuroprotective properties of LiCl and Vit E, which may be complementary to the antinociceptive effects of the two substances. Methods Thirty‐six male Wistar rats, 190.00 ± 10.00 g of body weight were randomly assigned to 6 experimental groups and administered with normal saline, Vit E, LiCl, or their combination, once daily for 21 days. CCI was used to induce neuropathic pain (NP) and mechanical allodynia was assessed using von Frey filaments and pinprick test. Open field maze (OFM) was used to assess the exploratory behavior. Biochemical parameters were assessed in the dorsal root ganglion after 21 days of treatment. Results Mechanical allodynia was developed in rats following CCI. Co‐administration of LiCl and Vit E synergistically reduced mechanical hyperalgesia in rats which were significantly different compared with the single administration of either Vit E or LiCl. Combined doses of Vit E and LiCl significantly increases the explorative behavior in the OFM. CCI increased malondialdehyde (MDA), tumor necrotic factor‐alpha (TNF‐α), calcitonin gene‐related polypeptide, calcium ion (Ca2+), and reduced superoxide dismutase (SOD) activities. Co‐administration of LiCl and Vit E significantly reduced MDA, TNF‐α, but increased SOD compared with ligated control. Discussion The findings revealed that the synergistic effects of the co‐administration of Vit E and LiCl in ameliorating NP are mediated by their anti‐inflammatory and antioxidant properties.

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The effects of co-administration of pregabalin and vitamin E on neuropathic pain induced by partial sciatic nerve ligation in male rats

Abstract: Our results showed antinociceptive effects of both vitamin E and pregabalin alone or in combination in PSNL rats and also neuroprotective properties without affecting locomotor activity.

Cited by 19 publications

References 54 publications

Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats

Antiallodynic interaction and motor performance of the pregabalin/thioctic acid and pregabalin/α‐tocopherol combinations in neonatal streptozotocin‐induced diabetic rats

Prenatal pregabalin is associated with sex‐dependent alterations in some behavioral parameters in valproic acid‐induced autism in rat offspring

Effects of co‐administration of vitamin E and lithium chloride on chronic constriction injury‐induced neuropathy in male Wistar rats: Focus on antioxidant and anti‐inflammatory mechanisms

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