Prevalence of HPV 16 and 18 and attitudes toward HPV vaccination trials in patients with cervical cancer in Mali

Teguété, Ibrahima; Dolo, A; Sangare, Kotou; Sissoko, Abdoulaye; Rochas, M; Beseme, Sarah; Tounkara, K; Yekta, Shahla; Groot, Anne S. De; Koïta, Ousmane

doi:10.1371/journal.pone.0172661

Cited by 11 publications

(6 citation statements)

References 30 publications

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“…Social support as encouragement or approval to participate in research by family members, community or friends was mentioned 18 times , in the top three reasons in six studies , and ranked sixth overall. Social support seemed to play a larger role in Asia than in other regions.…”

Section: Resultsmentioning

confidence: 99%

The willingness to participate in biomedical research involving human beings in low‐ and middle‐income countries: a systematic review

Browne

Rees

Delden

et al. 2019

Tropical Med Int Health

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ObjectivesTo systematically review reasons for the willingness to participate in biomedical human subjects research in low‐ and middle‐income countries (LMICs).MethodsFive databases were systematically searched for articles published between 2000 and 2017 containing the domain of ‘human subjects research’ in ‘LMICs’ and determinant ‘reasons for (non)participation’. Reasons mentioned were extracted, ranked and results narratively described.ResultsNinety‐four articles were included, 44 qualitative and 50 mixed‐methods studies. Altruism, personal health benefits, access to health care, monetary benefit, knowledge, social support and trust were the most important reasons for participation. Primary reasons for non‐participation were safety concerns, inconvenience, stigmatisation, lack of social support, confidentiality concerns, physical pain, efficacy concerns and distrust. Stigmatisation was a major concern in relation to HIV research. Reasons were similar across different regions, gender, non‐patient or patient participants and real or hypothetical study designs.ConclusionsAddressing factors that affect (non‐)participation in the planning process and during the conduct of research may enhance voluntary consent to participation and reduce barriers for potential participants.

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Section: Resultsmentioning

confidence: 99%

The willingness to participate in biomedical research involving human beings in low‐ and middle‐income countries: a systematic review

Browne

Rees

Delden

et al. 2019

Tropical Med Int Health

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“…Modelling projections suggest that high HPV vaccination coverage among girls in low-and middle-income countries (LMICs) can lead to cervical cancer elimination. Thus, the introduction of HPV vaccination is of especially urgent need in developing countries where there is a high burden of cervical cancer [5,[14][15][16][17][18][19]. A study on the trends of cervical cancer in Sub-Saharan Africa acclaimed that prophylactic vaccination for HPV and mass screening for cervical cancer are the key prevention strategies for cervical cancer [9].…”

Section: Introductionmentioning

confidence: 99%

Knowledge, Attitude and Practice of Main Stakeholders towards Human Papilloma Virus Infection and Vaccination in Mombasa and Tana-River Counties in Kenya: A Qualitative Study

et al. 2021

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Following a successful Human Papilloma Virus (HPV) vaccination pilot in 2013–2015 in Kitui county, Kenya introduced the HPV vaccine in October 2019 with a goal to immunize approximately 800,000 girls annually against HPV. Our study assessed the knowledge, attitudes, and practice of affected groups towards HPV infection and vaccination in two counties of Kenya. Semi-structured interviews from children aged between nine and thirteen years and key informants comprising of parents, head teachers, community leaders and health workers involved in HPV vaccination in health facilities from Mombasa and Tana-River counties were conducted. Content was analyzed thematically and coded for emerging themes using the QRS Nvivo 12 Plus software package. From our findings, a significant proportion of participants, especially children, have limited knowledge of the subject. Vaccination of boys was opposed by most participants. Parents and the community members are not in favor of HPV vaccination, as compared to the other groups. A similar pattern of inadequate knowledge and strongly opposed attitudes was observed in Tana-River and Mombasa. Active community involvement in primary prevention strategies may promote the uptake of the vaccine which can be achieved by robust awareness, modifying the negative beliefs about HPV vaccine and encouraging the perceptibility of HPV vaccination.

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“…It is important to note the dramatic difference between participants knowledge of HPV and of CC after the campaign. While 75% of women said that they had heard of CC {a huge improvement over the 55% [ N = 41/75] reporting this knowledge in GAIA VF's previous KAP studies ( 15 , 16 )}, only 13% knew what HPV was ( Table 2 ). Further, only 45% of women agreed that HPV causes CC.…”

Section: Discussionmentioning

confidence: 99%

A story-telling cloth approach to motivating cervical cancer screening in Mali

Crippin

Tounkara²,

Squibb

et al. 2022

Front. Public Health

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Ninety percent of deaths from Cervical cancer (CC) caused by Human Papilloma Virus (HPV) occur in low- and middle-income countries. CC is the 2nd most common cause of cancer in women in West Africa, where 12,000 women develop cervical cancer and more than 6,000 die from the disease, annually. While HPV vaccination and CC screening have dramatically reduced the incidence of CC and mortality from CC in developed countries, prevention of CC in West Africa is often limited to visual inspection of the cervix and surgical intervention. In previous studies of CC in Mali, we demonstrated that knowledge about the link between HPV and CC is limited, and that screening for CC is often delayed until women are symptomatic. For this intervention, a story-telling cloth (West African-style printed pagne) was designed for use as a starting point for educational sessions run by community health workers. Community outreach using the cloth during 6 months of 2015 resulted in a 5-fold higher uptake of cervical cancer screening and increased awareness of the potential to vaccinate adolescents against CC. 3,271 women were motivated to visit one of five participating clinics for CC screening, where a mere 600 women had been screened during the previous year. This study shows that a comprehensive, visual, community-centered education campaign coupled with coordinated support for local clinics improves uptake of CC screening.

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Prevalence of HPV 16 and 18 and attitudes toward HPV vaccination trials in patients with cervical cancer in Mali

Cited by 11 publications

References 30 publications

The willingness to participate in biomedical research involving human beings in low‐ and middle‐income countries: a systematic review

The willingness to participate in biomedical research involving human beings in low‐ and middle‐income countries: a systematic review

Knowledge, Attitude and Practice of Main Stakeholders towards Human Papilloma Virus Infection and Vaccination in Mombasa and Tana-River Counties in Kenya: A Qualitative Study

A story-telling cloth approach to motivating cervical cancer screening in Mali

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