μ2‐Dependent endocytosis of N‐cadherin is regulated by β‐catenin to facilitate neurite outgrowth

Chen, Yi‐Ting; Tai, Chin‐Yin

doi:10.1111/tra.12473

Cited by 10 publications

(8 citation statements)

References 59 publications

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“…The caveolin-mediated endocytic pathway, regulates the activity of signalling pathways such as WNT and TGFβ, both of which are known to play a central role in ESC pluripotency 23 – 25 . Endocytosis of CDH2 in an AP-2 adaptor complex dependent manner has been shown to be essential for neurite outgrowth and circuit formation 34 . Inhibition of RAB5 (early endosomal marker), or RAB11 (recycling endosome marker), showed defects in CDH2 trafficking, which resulted in neuronal migration defects during mouse cerebral cortex development 27 .…”

Section: Discussionmentioning

confidence: 99%

Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency

Mote

Mahajan

Padmanabhan

et al. 2017

Sci Rep

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Cell fate determination in the early mammalian embryo is regulated by multiple mechanisms. Recently, genes involved in vesicular trafficking have been shown to play an important role in cell fate choice, although the regulation of their expression remains poorly understood. Here we demonstrate for the first time that multiple endocytosis associated genes (EAGs) are repressed through a novel, dual mechanism in mouse embryonic stem cells (mESCs). This involves the action of the Polycomb Repressive Complex, PRC2, as well as post-transcriptional regulation by the ESC-specific cell cycle-regulating (ESCC) family of microRNAs. This repression is relieved upon differentiation. Forced expression of EAGs in mESCs results in a decrease in pluripotency, highlighting the importance of dual repression in cell fate regulation. We propose that endocytosis is critical for cell fate choice, and dual repression may function to tightly regulate levels of endocytic genes.

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Section: Discussionmentioning

confidence: 99%

Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency

Mote

Mahajan

Padmanabhan

et al. 2017

Sci Rep

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“…This indicates that the cell adhesion may be decreased by the internalization of cadherins through clathrin-mediated endocytosis (CME). The µ2 subunit of the AP-2 adaptor complex interacts with several motifs of the intracellular domain of N-cadherin, and it is responsible for its endocytosis [20], while the β-catenin inhibits N-cadherin endocytosis by masking these motifs. The removal of β-catenin enables µ2 binding to N-cadherin, thereby increasing clathrin-mediated N-cadherin endocytosis in the neurite outgrowth.…”

Section: Cadherins-history and Functionmentioning

confidence: 99%

The Central Role of Cadherins in Gonad Development, Reproduction, and Fertility

Piprek

Kloc

Mizia

et al. 2020

IJMS

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Cadherins are a group of membrane proteins responsible for cell adhesion. They are crucial for cell sorting and recognition during the morphogenesis, but they also play many other roles such as assuring tissue integrity and resistance to stretching, mechanotransduction, cell signaling, regulation of cell proliferation, apoptosis, survival, carcinogenesis, etc. Within the cadherin superfamily, E- and N-cadherin have been especially well studied. They are involved in many aspects of sexual development and reproduction, such as germline development and gametogenesis, gonad development and functioning, and fertilization. E-cadherin is expressed in the primordial germ cells (PGCs) and also participates in PGC migration to the developing gonads where they become enclosed by the N-cadherin-expressing somatic cells. The differential expression of cadherins is also responsible for the establishment of the testis or ovary structure. In the adult testes, N-cadherin is responsible for the integrity of the seminiferous epithelium, regulation of sperm production, and the establishment of the blood–testis barrier. Sex hormones regulate the expression and turnover of N-cadherin influencing the course of spermatogenesis. In the adult ovaries, E- and N-cadherin assure the integrity of ovarian follicles and the formation of corpora lutea. Cadherins are expressed in the mature gametes and facilitate the capacitation of sperm in the female reproductive tract and gamete contact during fertilization. The germ cells and accompanying somatic cells express a series of different cadherins; however, their role in gonads and reproduction is still unknown. In this review, we show what is known and unknown about the role of cadherins in the germline and gonad development, and we suggest topics for future research.

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“…Upon LTD-inducing stimulation, AMPAR is sorted into clathrin-coated pits and efficiently removed from the plasma membrane, thereby reducing the sensitivity of neurons to neurotransmitters (Lee et al, 2002;Rosendale et al, 2017). During axon growth and before synapse formation, macropinocytosis, CME and an endophilin-dependent pathway (akin to FEME) are required to modulate attractive and repulsive receptors (Chen and Tai, 2017;Tojima and Kamiguchi, 2015;Chang et al, 2017). Finally, macropinocytosis mediates neuron-to-neuron transmission of protein aggregates, perhaps also supporting the spread of amyloids during neurodegenerative diseases (Yerbury, 2016).…”

Section: Endocytosis In Terminally Differentiated Cellsmentioning

confidence: 99%

Endocytosis in proliferating, quiescent and terminally differentiated cells

Hinze

Boucrot

2018

Journal of Cell Science

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Endocytosis mediates nutrient uptake, receptor internalization and the regulation of cell signaling. It is also hijacked by many bacteria, viruses and toxins to mediate their cellular entry. Several endocytic routes exist in parallel, fulfilling different functions. Most studies on endocytosis have used transformed cells in culture. However, as the majority of cells in an adult body have exited the cell cycle, our understanding is biased towards proliferating cells. Here, we review the evidence for the different pathways of endocytosis not only in dividing, but also in quiescent, senescent and terminally differentiated cells. During mitosis, residual endocytosis is dedicated to the internalization of caveolae and specific receptors. In non-dividing cells, clathrin-mediated endocytosis (CME) functions, but the activity of alternative processes, such as caveolae, macropinocytosis and clathrin-independent routes, vary widely depending on cell types and functions. Endocytosis supports the quiescent state by either upregulating cell cycle arrest pathways or downregulating mitogen-induced signaling, thereby inhibiting cell proliferation. Endocytosis in terminally differentiated cells, such as skeletal muscles, adipocytes, kidney podocytes and neurons, supports tissue-specific functions. Finally, uptake is downregulated in senescent cells, making them insensitive to proliferative stimuli by growth factors. Future studies should reveal the molecular basis for the differences in activities between the different cell states.

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μ2‐Dependent endocytosis of N‐cadherin is regulated by β‐catenin to facilitate neurite outgrowth

Cited by 10 publications

References 59 publications

Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency

Dual repression of endocytic players by ESCC microRNAs and the Polycomb complex regulates mouse embryonic stem cell pluripotency

The Central Role of Cadherins in Gonad Development, Reproduction, and Fertility

Endocytosis in proliferating, quiescent and terminally differentiated cells

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