Valor de la PET/TC cerebral con 18 F-fluorocolina en la detección de recurrencias de neoplasias primarias del sistema nervioso central

Montes, A.; Fernández, A.; Camacho, Valle; Quintana, C. de; Gallego, Óscar; Craven-Bartle, Jordi; López, David Gómez; Molet, J.; Gómez‐Anson, Beatriz; Carrió, Ignasi

doi:10.1016/j.remn.2016.11.005

Cited by 4 publications

(1 citation statement)

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“…Choline tracers such as [ 11 C]choline [70] and [ 18 F]fluorocholine [77] have shown promising results for the identification and delineation of various CNS tumors, including LGG, HGG, and extra-axial tumors such as meningioma and schwannoma [78][79][80]. Choline is a precursor for the synthesis of phospholipids.…”

Section: Diagnostic Imaging Of Abnormal Metabolic Processesmentioning

confidence: 99%

The Added Value of Diagnostic and Theranostic PET Imaging for the Treatment of CNS Tumors

Pruis

Dongen

Zanten

2020

IJMS

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This review highlights the added value of PET imaging in Central Nervous System (CNS) tumors, which is a tool that has rapidly evolved from a merely diagnostic setting to multimodal molecular diagnostics and the guidance of targeted therapy. PET is the method of choice for studying target expression and target binding behind the assumedly intact blood–brain barrier. Today, a variety of diagnostic PET tracers can be used for the primary staging of CNS tumors and to determine the effect of therapy. Additionally, theranostic PET tracers are increasingly used in the context of pharmaceutical and radiopharmaceutical drug development and application. In this approach, a single targeted drug is used for PET diagnosis, upon the coupling of a PET radionuclide, as well as for targeted (nuclide) therapy. Theranostic PET tracers have the potential to serve as a non-invasive whole body navigator in the selection of the most effective drug candidates and their most optimal dose and administration route, together with the potential to serve as a predictive biomarker in the selection of patients who are most likely to benefit from treatment. PET imaging supports the transition from trial and error medicine to predictive, preventive, and personalized medicine, hopefully leading to improved quality of life for patients and more cost-effective care.

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