“… 10 , 11 , 12 , 13 However, the development of resistance to apoptosis induced by chemotherapeutic drugs during treatment drastically decreases the efficacy of chemotherapy and is a key mechanism of the therapeutic escape of cancer cells and a major obstacle to cancer therapy. 14 , 15 , 16 In addition, all clinical chemotherapeutic agents have severe adverse effects, such as cardiomyopathy, typhlitis, acute myelotoxicity, and other non-specific toxicities induced by high drug doses. 10 , 11 , 12 , 13 Thus, it is urgent to explore potential mechanisms involved in chemotherapy resistance, develop new drugs targeting drug-resistant tumors, and explore new compounds for combination therapy to enhance the therapeutic effects of anti-tumor drugs with minimal adverse effects.…”