Prostate cancer detection rate in Indonesian men

Mochtar, Chaidir Arif; Atmoko, Widi; Umbas, Rainy; Hamid, Agus Rizal Ardy Hariandy

doi:10.1016/j.asjsur.2017.01.001

Cited by 13 publications

(9 citation statements)

References 31 publications

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“…Results from this relatively small single-centre study cannot be readily extrapolated to other geographical settings. It should be noted, however, that the prevalence of cancer observed in our study population is reflected well in other regional studies, and that so far cytopathology itself has been a universal, ethnically unbiased diagnostic approach (Figure 1) [30,31].…”

Section: Discussionsupporting

confidence: 76%

Accuracy of Tumour-Associated Circulating Endothelial Cells as a Screening Biomarker for Clinically Significant Prostate Cancer

Bhakdi

Suriyaphol

Thaicharoen³

et al. 2019

Cancers

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Even though more than 350,000 men die from prostate cancer every year, broad-based screening for the disease remains a controversial topic. Guidelines demand that the only commonly accepted screening tool, prostate-specific antigen (PSA) testing, must be followed by prostate biopsy if results are elevated. Due to the procedure’s low positive predictive value (PPV), however, over 80% of biopsies are performed on healthy men or men with clinically insignificant cancer—prompting calls for new ways of vetting equivocal PSA readings prior to the procedure. Responding to the challenge, the present study investigated the diagnostic potential of tumour-associated circulating endothelial cells (tCECs), which have previously been described as a novel, blood-based biomarker for clinically significant cancers. Specifically, the objective was to determine the diagnostic accuracy of a tCEC-based blood test to detect clinically significant prostate cancer (defined as Gleason score ≥ 3 + 4) in high-risk patients. Performed in a blinded, prospective, single-centre set-up, it compared a novel tCEC index test with transrectal ultrasound-guided biopsy biopsy as a reference on a total of 170 patients and found that a tCEC add-on test will almost double the PPV of a standalone PSA test (32% vs. 17%; p = 0.0012), while retaining a negative predictive value above 90%.

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Section: Discussionsupporting

confidence: 76%

Accuracy of Tumour-Associated Circulating Endothelial Cells as a Screening Biomarker for Clinically Significant Prostate Cancer

Bhakdi

Suriyaphol

Thaicharoen³

et al. 2019

Cancers

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“…A transrectal ultrasound-guided prostate biopsy is the gold standard method for the histopathological diagnosis of prostate cancer 9 . Mochtar et al 10 described the transrectal ultrasound-guided sextant prostate biopsy, which is an inaccurate means of cancer detection with 10-30% of false-negative rates. The European Association of Urology guidelines suggests prostate biopsy by either the transrectal or transperineal approach for the initial diagnosis 11 .…”

Section: Discussionmentioning

confidence: 99%

High D-dimer levels are associated with prostate cancer

Kalkan

Çalışkan²

2020

Rev. Assoc. Med. Bras.

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“… 9 Although transrectal ultrasound guided sextant prostate biopsy was described by Hodge et al, six-core biopsy is an inaccurate means of cancer detection and has a 10–30% false negative rate. 10 European Association of Urology 2015 guidelines suggest 10–12 systematic cores for initial diagnosis. 11 The authors reported the prostate cancer detection rate was 13.3–35% in patients who underwent six and 12 prostate biopsies, respectively.…”

Section: Discussionmentioning

confidence: 99%

Fibrinogen and D-dimer levels in prostate cancer: Preliminary results

Çalışkan

Sungur

2017

Prostate International

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BackgroundProstate cancer is one of the most common malignancy in men. The main risk factors for coagulation activation and thrombosis are malignancy and older age. The thrombosis risk may be associated with increased level of coagulation markers such as fibrinogen and D-dimer. The aim of this study is evaluate the relationship between coagulation markers and prostate cancer.MethodsThis prospective study includes the patients who underwent transrectal ultrasound guided prostate biopsy and prostate surgery was performed between January 2015 and January 2016. Plasma prostate specific antigen (PSA), free PSA (fPSA), percentage fPSA, D-dimer and fibrinogen levels were measured before the procedures. The patients were divided into two groups according to the pathology results. The patients with benign prostate hyperplasia were in group 1 and the patients with prostate cancer were in group 2.ResultsThere were 76 patients in the current study. There were 53 patients in group 1 and 23 patients in group 2. The mean age of the patients, PSA, fPSA, fibrinogen and D-dimer levels was 65.33 ± 7.47 years, 8.21 ± 4.59, 1.41 ± 0.74 ng/ml, 309.75 ± 80.46 mg/dl, 0.42 ± 0.39 ug/ml in group 1. In group 2; the mean age of the patients, PSA, fPSA, fibrinogen and D-dimer levels was 66.08 ± 6.7 years, 145.69 ± 509.35, 7.32 ± 15 ng/ml, 312.16 ± 69.48 mg/dl, 1.09 ± 2.11 ug/ml. The prostate biopsy and transurethral surgery were performed in 64(%84.21) and 12(%15.79) patients.ConclusionThe present study demonstrated that plasma D-dimer level was higher in patients with prostate cancer. Further studies that include large number of patients are needed to define the relationship between prostate cancer and coagulation disorder.

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Prostate cancer detection rate in Indonesian men

Abstract: The overall detection rate of prostate cancer in Indonesian men was 28.7%. The prostate cancer detection rate appeared to be lower than that observed in white men.

Cited by 13 publications

References 31 publications

Accuracy of Tumour-Associated Circulating Endothelial Cells as a Screening Biomarker for Clinically Significant Prostate Cancer

Accuracy of Tumour-Associated Circulating Endothelial Cells as a Screening Biomarker for Clinically Significant Prostate Cancer

High D-dimer levels are associated with prostate cancer

Fibrinogen and D-dimer levels in prostate cancer: Preliminary results

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