“…Strikingly, the GFP + de-differentiated adipocytes have very low expression of the common adipocyte markers adiponectin ( Adipoq ), fatty acid binding protein 4 ( Fabp4 ), peroxisome proliferator activated receptor gamma γ ( Pparg ), resistin ( Retn ) and angiotensinogen ( Agt ), similarly to GFP- cells (Figure 4D). Meanwhile, these GFP+ cells have regained expression of common preadipocyte markers, such as Pdgfra , Pdgfrb , lymphocyte antigen 6 complex, locus A ( Ly6a ), Cd34, and fibronectin receptor beta subunit ( Itgb1 ) (Figure 4E) (Hepler et al, 2017; Wang and Seale, 2016). These de-differentiated adipocytes also increased expressions of some common fibroblast markers, such as Vimentin ( Vim ), Collagen Type I Alpha 1 Chain ( Col1a1 ), Smooth Muscle α Actin ( Acta2 ), and fibroblast activation protein ( Fap ), again, similarly to GFP- cells (Figure 4F).…”