282 Varying Predictive Values Dictate the Need to Standarise Commerical Kits for Ttg Testing

Abstract

In Sweden, a precipitous rise in the incidence of celiac disease (CD) in children below two years of age occurred during 1985-1995 in Sweden. The period is well suited for investigating the socioeconomic and geographical distribution of CD in Sweden. Previous research on the importance of socioeconomic position (SEP) in CD has produced conflicting results. All singleton children born in Sweden 1987Sweden -1993 were identified in the Swedish Medical Birth Record. We linked several other national registries to obtain socioeconomic, medical, and demographic information. We applied multilevel (counties, municipalities, and individuals) logistic regression methods to quantify a possible geographical clustering of CD cases and to investigate the association between SEP and CD. Using equalized family income quintile groups as a measure of SEP, we found that in the lowest quintile group the association with CD was for boys OR 1.18 (95 % CI 0.90-1.55) and for girls OR 0.82 (95 % CI 0.67-1.00). Using the Median Odds Ratio (MOR) as a measure of geographical variation clustering, we found that for boys the MOR was 1.76 (95 % CrI 1.46-2.00) and for girls 1.92 (95 % CrI 1.49-2.30). We also identified a reduced odds of CD in offspring having a mother born outside Sweden, boys OR 0.75 (95 % CI 0.57-0.98) and girls OR 0.64 (95 % CI 0.51-0.79). The study show that SEP is of minor importance in the distribution of CD among small children. However, we identified a significant geographical clustering of CD in Sweden during 1987-1993. VARYING PREDICTIVE VALUES DICTATE THE NEED TO STANDARISE COMMERICAL KITS FOR TTG TESTING D. Kesavelu Paediatric Gastroenterology, Alder Hey Childrens NHS Foundation Trust, Liverpool, UKBackground: Over the previous several months we have noticed an increased false positive coeliac serology rate in patients referred from a particular catchment area of our centre. We investigated serologic methods employed and compared it to methods used at our centre and other hospitals in our catchment.

Genes, circuits, and precision therapies for autism and related neurodevelopmental disorders

“…Environmental influences such as perinatal injury and maternal infection could play a significant role in the context of a susceptible genetic background and contribute to the development of ASD. For instance, premature infants with isolated cerebellar hemorrhage have a 30 fold higher incidence of ASDs compared to the general population (15, 16). Other epidemiological studies have implicated activation of the maternal immune system during gestation as a contributor to the development of various neuropsychiatric disorders (17–19) and more specifically in the development of autism (19–21).…”

“…Second, imaging studies of patients diagnosed with ASD indicate gray and white matter abnormalities in the cerebellum, dating to early childhood (86–90). Premature infants with isolated cerebellar hemorrhage have a higher incidence of ASDs, suggesting that cerebellar dysfunction early in life contributes to the pathogenesis of autism (15, 16). The developmental vulnerability of this circuit is further illustrated by study of genetic syndromes associated with ASD.…”

Tract Profiles of the Cerebellar White Matter Pathways in Children and Adolescents

“…The present study examined the structural characteristics of the three major pathways of the cerebellar peduncles in a healthy pediatric sample. Examining structural properties of the peduncles in children has important theoretical implications for understanding the pathways of neural signals in motor, cognitive, and emotional processes (19, 20). Quantifying individual differences in healthy and typically developing children is a necessary prerequisite to understanding variations in clinical conditions that affect the cerebellum.…”

Neuroimaging biomarkers of preterm brain injury: toward developing the preterm connectome

“…Additionally, cerebellar volume has not been found to predict outcome at 2 years of age [106], but data are controversial [108]. More recent studies have demonstrated relationships between cerebellar structure and supratentorial development injury [109,110]. …”