282 POSTER 5-Methyl-indirubin: a CDK-inhibitor with activity in human tumor models in vivo

Quantitative and selective assay of 5-methylindirubine, an inhibitor of cyclin-dependent kinases, in murine plasma using coupled liquid chromatography and electrospray tandem mass spectrometry

“…Moreover, 5-MI showed antitumor efficacy in a variety of solid tumor xenografts, e.g. colon cancer, non small cell lung cancer, mammary cancer, melanoma, prostate cancer, and renal cancer, following oral administration [20].…”