New insights into crosstalk in the kidney

Abstract

Most of the literature cited concern glomerular crosstalk but also tubular and interstitial crosstalk are being reviewed. Mechanistic insight into the communication between the cells may help us find new targets for treating kidney disease.

Glomerular Endothelial Cell Stress and Cross-Talk With Podocytes in Early Diabetic Kidney Disease

“…Whether the diabetic milieu effects on podocytes could promote podocyte detachment, i.e., preceded by any kind of podocyte cell death, such as apoptosis, necrosis, necroptosis, ferroptosis, podoptosis, and mitotic catastrophe ( 44 – 48 ), still remains under debate and not the focus of this review. The maintenance of the glomerular ultrafiltration barrier requires the interaction of all three glomerular cell types ( 49 , 50 ) including a multidirectional cross-talk between podocytes, mesangial cells and endothelial cells ( 51 – 53 ), as well as parietal epithelial cells ( 54 , 55 ). Understanding the key interactions between all the cells in the glomerulus during the development of DKD may provide us with an opportunity for identifying novel interventions that can either stop or reverse its progression.…”

Endothelin receptor-A mediates degradation of the glomerular endothelial surface layer via pathologic crosstalk between activated podocytes and glomerular endothelial cells

“…[45][46][47] In response to injury, these interactions can spread deleterious signals across glomerular compartments. [48][49][50] Here we demonstrate that pathologic crosstalk between activated podocytes and GECs during early stages of glomerular disease involves Edn1/EdnrA interaction on GECs, increased mitochondrial ROS and activation of ESL degradation/remodeling may underlie early glomerular permeability, suggesting an unprecedented opportunity to explore potential actionable targets in GECs for chronic kidney disease.…”

SHIPping out diabetes—Metformin, an old friend among new SHIP2 inhibitors

“…Crosstalk between the different cell types is also essential in the tubulointerstitial compartment and may play an important role in renal disease progression . More detailed discussion on the crosstalk between the different renal cell types is beyond the scope of this review, but the given examples underscore the complexity of the regulation of the glomerular filtration and emphasize the role of all glomerular cell types in maintaining the normal kidney function, as well as in contributing to the dysfunction of the filtration barrier in renal diseases, including DKD.…”

“…More detailed discussion on the crosstalk between the different renal cell types is beyond the scope of this review, but the given examples underscore the complexity of the regulation of the glomerular filtration and emphasize the role of all glomerular cell types in maintaining the normal kidney function, as well as in contributing to the dysfunction of the filtration barrier in renal diseases, including DKD. The topic of glomerular cell crosstalk has been extensively covered by several recent reviews …”