Otolaryngology outreach to Komfo Anokye Teaching Hospital: a medical and educational partnership

Waller, Beverly; Larsen‐Reindorf, Rita; Duah, M; Opoku-Buabeng, J; Edwards, Bruce M.; Brown, David J.; Moyer, John H.; Prince, Mark; Basura, Gregory J.

doi:10.1017/s0022215117000330

Cited by 6 publications

(4 citation statements)

References 6 publications

(4 reference statements)

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“…However, parents/guardians of these children gave the information on the onset of the condition. The late diagnostic of HI in Ghanaian children is partly tied to the limited number of hearing assessment facilities (Waller et al, 2017). In addition, the majority of the HI students were living in remote rural settlements often with unmemorable roads and hence the difficulty of having access to quality health care.…”

Section: Discussionmentioning

confidence: 99%

GJB2 and GJB6 Mutations in Non-Syndromic Childhood Hearing Impairment in Ghana

et al. 2019

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Our study aimed to investigate GJB2 (connexin 26) and GJB6 (connexin 30) mutations associated with non-syndromic childhood hearing impairment (HI) as well as the environmental causes of HI in Ghana. Medical reports of 1,104 students attending schools for the deaf were analyzed. Families segregating HI, as well as isolated cases of HI of putative genetic origin were recruited. DNA was extracted from peripheral blood followed by Sanger sequencing of the entire coding region of GJB2. Multiplex PCR and Sanger sequencing were used to analyze the prevalence of GJB6-D3S1830 deletion. Ninetyseven families segregating HI were identified, with 235 affected individuals; and a total of 166 isolated cases of putative genetic causes, were sampled from 11 schools for the deaf in Ghana. The environmental factors, particularly meningitis, remain a major cause of HI impairment in Ghana. The male/female ratio was 1.49. Only 59.6% of the patients had their first comprehensive HI test between 6 to 11 years of age. Nearly all the participants had sensorineural HI (99.5%; n = 639). The majority had pre-lingual HI (68.3%, n = 754), of which 92.8% were congenital. Pedigree analysis suggested autosomal recessive inheritance in 96.9% of the familial cases. GJB2-R143W mutation, previously reported as founder a mutation in Ghana accounted for 25.9% (21/81) in the homozygous state in familial cases, and in 7.9% (11/140) of non-familial non-syndromic congenital HI cases, of putative genetic origin. In a control population without HI, we found a prevalent of GJB2-R143W carriers of 1.4% (2/145), in the heterozygous state. No GJB6-D3S1830 deletion was identified in any of the HI patients. GJB2-R143W mutation accounted for over a quarter of familial non-syndromic HI in Ghana and should be investigated in clinical practice. The large connexin 30 gene deletion (GJB6-D3S1830 deletion) does not account for of congenital non-syndromic HI in Ghana. There is a need to employ next generation sequencing approaches and functional genomics studies to identify the other genes involved in most families and isolated cases of HI in Ghana.

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Section: Discussionmentioning

confidence: 99%

GJB2 and GJB6 Mutations in Non-Syndromic Childhood Hearing Impairment in Ghana

et al. 2019

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“…The advantages are that it is easier in this model to provide a comprehensive range of specialist care, including surgery, as only one centre is used. This can also help to keep costs low, to provide continuity in training 73 and to implement processes for continual improvement.…”

Section: Central Delivery Of Care Modelmentioning

confidence: 99%

Models of service delivery for ear and hearing care in remote or resource-constrained environments

Bhutta

2018

J. Laryngol. Otol.

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BackgroundThere is poor availability of ear and hearing services globally, because of a lack of infrastructure, funding, equipment and appropriately trained personnel. When deciding upon delivery of ear and hearing services, an approach based upon community assessment is advocated, with subsequent asset mapping and acquisition.ObjectivesSome of the challenges to delivery of care in resource-constrained or remote environments are acknowledged, with discussion of several existing models of service delivery, and their advantages and disadvantages. Public health and telehealth are also mentioned. This article may assist those trying to set up new programmes in ear and hearing health.

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“…The program is now self-sustaining and, since 1995, has received support from the Ghanaian Ministry of Health, Ministry of Education, and the Ghana Health Service (Anderson et al, 2007;Clinton et al, 2010). Since 1993, robust programs in emergency medicine (Martel et al, 2014;Mould-Millman et al, 2015;Osei-Ampofo et al, 2013Oteng and Donkor, 2014;Oteng et al, 2020), family medicine (Essuman et al, 2019;Toma et al, 2020) otolaryngology (Waller et al, 2017), ophthalmology (Global REACH, 2019), psychiatry (Natala, et al, 2018), and other medical disciplines (Essuman, et al, 2019) have evolved at these same teaching hospitals, all with the involvement of University of Michigan Medical School faculty. Medical student exchanges going in both directions remain established, as well as exchanges of residents (medical school graduates who are pursing training as specialists in areas such as surgery, internal medicine, or obstetrics/ gynecology, called "postgraduate trainees" or "postgraduates" for short in Ghana, and "resident, " "house officer, " or "graduate medical education (GME) trainee" in the United States; "intern" is no longer formally accepted for those in their first year of residency, although widely used) (Abedini et al, 2014(Abedini et al, , 2015Danso-Bamfo et al, 2017;Lawrence et al, 2020).…”

Section: Introduction and The "End Of The Story"mentioning

confidence: 99%

More than "First, Do No Harm"

Johnson

2023

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Using personal experience and narrative, as well as the voices of students, trainees, and academic colleagues, this book illustrates how an initiative beginning over thirty years ago to train obstetrician-gynecologists in Ghana can serve as a model for global engagement by universities and learners at many levels. In addition to detailing a proven sustainable model for global health programs, this book highlights the ethical and moral imperatives participants should expect and demand of truly engaged academic global health.

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Otolaryngology outreach to Komfo Anokye Teaching Hospital: a medical and educational partnership

Cited by 6 publications

References 6 publications

GJB2 and GJB6 Mutations in Non-Syndromic Childhood Hearing Impairment in Ghana

GJB2 and GJB6 Mutations in Non-Syndromic Childhood Hearing Impairment in Ghana

Models of service delivery for ear and hearing care in remote or resource-constrained environments

More than "First, Do No Harm"

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