Presence of cutaneous human papillomavirus <scp>DNA</scp> in squamous cell carcinoma of the scalp: a case series

Plaça, M. La; Venturoli, Simona; Barbieri, Daniela; Nocera, Martina; Patrizi, Annalisa; Landini, Maria Paola; Fanti, Pier ­Alessandro; Dika, Emi

doi:10.1111/jdv.14168

Cited by 7 publications

(5 citation statements)

References 10 publications

(21 reference statements)

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“…In addition to warts, human papillomavirus has been detected in benign neoplasms, premalignant lesions (such as actinic keratoses), and malignant tumors [7,[9][10][11][12][13][14][15][16][17]. A study of 51 non-genital seborrheic keratoses observed that two acanthotic seborrheic keratoses were positive for alpha human papillomavirus deoxyribonucleic acid (DNA): high-risk human papillomavirus 31 and low-risk human papillomavirus 42 [16].…”

Section: Discussionmentioning

confidence: 99%

“…There are also several individual reports or case series of patients with cutaneous squamous cell carcinoma in which human papillomavirus has been documented. These have occurred at locations on the head including the scalp and ear [11,12]. They have also been shown to develop on the distal upper extremity, such as the hands, fingers, and nail unit [13][14][15].…”

Section: Discussionmentioning

confidence: 99%

“…The carcinomas demonstrated either one (three tumors), two (two tumors), or three (four tumors) subtypes of beta human papillomavirus. The investigators postulated that the development of the scalp cutaneous squamous cell carcinomas occurred secondary to a synergistic effect of ultraviolet radiation and the human papillomavirus gene expression [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous Squamous Cell Carcinoma Masquerading as a Verruca: Case Report and Literature Review of Coexisting Wart and Invasive Squamous Cell Carcinoma on the Hand

Cohen¹,

Erickson²,

Calame³

2022

Cureus

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A verruca is a human papillomavirus-associated infection of the mucosal or cutaneous epithelium. Cutaneous squamous cell carcinoma is an invasive skin cancer that commonly occurs on sun-exposed locations. Human papillomavirus infection has also been demonstrated to be a cocarcinogen, along with ultraviolet radiation, in the pathogenesis of cutaneous squamous cell carcinoma. A 63-year-old man presented with a verrucous nodule of nine months duration on his dorsal left hand. The clinical differential diagnosis included a wart and a small punch biopsy of the lesion showed a verruca. The lesion continued to enlarge and the possibility of a squamous cell carcinoma was considered. A second larger shave biopsy of the residual lesion was performed and the microscopic evaluation revealed not only a benign verruca at the lateral portion of the nodule but also an invasive squamous cell carcinoma in the center of the lesion. We hypothesize that the patient's human papillomavirus-associated wart may have contributed to the development of his cutaneous squamous cell carcinoma. Therefore, in an individual with a clinically suspected or biopsy-confirmed wart that persists despite lesion-directed treatment, additional evaluation of the lesion should be considered to assess whether an alternative or concurrent tumor, such as a cutaneous squamous cell carcinoma, is present.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cutaneous Squamous Cell Carcinoma Masquerading as a Verruca: Case Report and Literature Review of Coexisting Wart and Invasive Squamous Cell Carcinoma on the Hand

Cohen¹,

Erickson²,

Calame³

2022

Cureus

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“…Although the genomes of some types of β-HPV are frequently detected in some cases of NMSC in healthy individuals, they can also be found in premalignant lesions [74] and even in healthy skin. However, epidemiological studies have shown that patients with a history of cSCC have a greater probability of being positive for β-HPV infection than do normal individuals [75].…”

Section: Cutaneous Squamous Cell Carcinomamentioning

confidence: 99%

Viruses and Skin Cancer

Becerril

Corchado-Cobos

García-Sancha

et al. 2021

IJMS

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Advances in virology and skin cancer over recent decades have produced achievements that have been recognized not only in the field of dermatology, but also in other areas of medicine. They have modified the therapeutic and preventive solutions that can be offered to some patients and represent a significant step forward in our knowledge of the biology of skin cancer. In this paper, we review the viral agents responsible for different types of skin cancer, especially for solid skin tumors. We focus on human papillomavirus and squamous cell cancers, Merkel cell polyomavirus and Merkel cell carcinoma, and human herpesvirus 8 and Kaposi’s sarcoma.

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“… 43 Risk factors include UV exposure, fair phototypes, history of skin cancer, increased age and immunosuppression 44,45 . The role of human papillomavirus has been proposed to be involved in its pathogenesis 46,47 . Advanced age is associated to a higher risk of metastatic spreading 43 .…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

Malignant cutaneous tumours of the scalp: always remember to examine the head

Dika

Patrizi

Veronesi

et al. 2020

Acad Dermatol Venereol

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Around 2% of cutaneous neoplasms arise in the scalp (scalp tumours: STs). They can be classified as primary STs (epithelial, melanocytic and adnexal) or metastatic (from distal tumours or as a spreading from contiguous structures). This anatomic location is usually poorly examined during dermatological consultations, also due to the presence of the hair cover. Moreover, self-examination of the hair-covered skin is often harder for the patient. The peculiar features of the scalp may explain the worse prognosis of STs compared with neoplasms of other locations. The hair coverage protects the scalp from UV radiations, but due to the complex pathogenesis of STs, they may also develop in younger patients. Until now, STs have been not extensively investigated in the dermatological literature, and most publications are written by otolaryngologists, or by head, neck and plastic surgeons. Thus, dermatologists above all have the opportunity and the task to explore the scalp carefully, with the opportunity to make an early diagnosis, possibly changing the patient's prognosis. The aim of this paper was to review the main STs in order to increase awareness among dermatology specialists.

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Presence of cutaneous human papillomavirus DNA in squamous cell carcinoma of the scalp: a case series

Cited by 7 publications

References 10 publications

Cutaneous Squamous Cell Carcinoma Masquerading as a Verruca: Case Report and Literature Review of Coexisting Wart and Invasive Squamous Cell Carcinoma on the Hand

Cutaneous Squamous Cell Carcinoma Masquerading as a Verruca: Case Report and Literature Review of Coexisting Wart and Invasive Squamous Cell Carcinoma on the Hand

Viruses and Skin Cancer

Malignant cutaneous tumours of the scalp: always remember to examine the head

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