The role of ST2 and ST2 genetic variants in schistosomiasis

Long, Xin; Daya, Michelle; Zhao, Jianping; Rafaels, Nicholas; Liang, Huifang; Potee, Joseph; Campbell, Monica; Zhang, Bixiang; Araújo, Maria Ilma; Oliveira, Ricardo Riccio; Mathias, Rasika A.; Gao, Li; Ruczinski, Ingo; Georas, Steve N.; Vercelli, Donata; Beaty, Terri H.; Barnes, Kathleen C.; Chen, Xiaoping; Chang, Qian

doi:10.1016/j.jaci.2016.12.969

Cited by 14 publications

(14 citation statements)

References 43 publications

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“…Another type-2 cytokine receptor, ST2 in its soluble form (sST2), has been reported to be present at high level in the serum of diseased patients with advanced hepatic fibrosis during S. japonicum infection ( 52 ).…”

Section: Humans Factors Associated With Liver Fibrosis During Schistomentioning

confidence: 99%

Host Regulators of Liver Fibrosis During Human Schistosomiasis

et al. 2018

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Liver fibrosis is a wound-healing process purposely aimed at restoring organ integrity after severe injury caused by autoimmune reactions, mechanical stress or infections. The uncontrolled solicitation of this process is pathogenic and a pathognomonic feature of diseases like hepatosplenic schistosomiasis where exacerbated liver fibrosis is centrally positioned among the drivers of the disease morbidity and mortality. Intriguingly, however, liver fibrosis occurs and progresses dissimilarly in schistosomiasis-diseased individuals with the same egg burden and biosocial features including age, duration of residence in the endemic site and gender. This suggests that parasite-independent and currently poorly defined host intrinsic factors might play a defining role in the regulation of liver fibrosis, the hallmark of morbidity, during schistosomiasis. In this review, we therefore provide a comprehensive overview of all known host candidate regulators of liver fibrosis reported in the context of human schistosomiasis.

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Section: Humans Factors Associated With Liver Fibrosis During Schistomentioning

confidence: 99%

Host Regulators of Liver Fibrosis During Human Schistosomiasis

et al. 2018

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“…By using a generalized estimating equation model, 3 single nucleotide polymorphisms (SNPs) associated with higher Schistosoma species-soluble adult worm antigen-specific IgE/IgG 4 (a measure of resistance to S mansoni) were found. 61 The most significant SNP mapped to intron 1 and the allele, which has been shown to confer asthma risk in an African-American population, also conferred protection against schistosomiasis.…”

Section: Variants That Affect the T H 2 Immune Responsementioning

confidence: 99%

Global issues in allergy and immunology: Parasitic infections and allergy

Cruz

Cooper

Figueiredo

et al. 2017

Journal of Allergy and Clinical Immunology

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Allergic diseases are on the increase globally in parallel with a decrease in parasitic infection. The inverse association between parasitic infections and allergy at an ecological level suggests a causal association. Studies in human subjects have generated a large knowledge base on the complexity of the interrelationship between parasitic infection and allergy. There is evidence for causal links, but the data from animal models are the most compelling: despite the strong type 2 immune responses they induce, helminth infections can suppress allergy through regulatory pathways. Conversely, many helminths can cause allergic-type inflammation, including symptoms of "classical" allergic disease. From an evolutionary perspective, subjects with an effective immune response against helminths can be more susceptible to allergy. This narrative review aims to inform readers of the most relevant up-to-date evidence on the relationship between parasites and allergy. Experiments in animal models have demonstrated the potential benefits of helminth infection or administration of helminth-derived molecules on chronic inflammatory diseases, but thus far, clinical trials in human subjects have not demonstrated unequivocal clinical benefits. Nevertheless, there is sufficiently strong evidence to support continued investigation of the potential benefits of helminth-derived therapies for the prevention or treatment of allergic and other inflammatory diseases.

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“…However, IL-33 has been shown to induce multivalent functions, leading in anti or pro-inflammatory effects in numerous pathologies (26). While several studies focussed on the role of IL-33 in driving hepatic disease during schistosomiasis (27–29), hepatitis (30–32), or malaria (33), alone, very few investigations, if any at all, have been performed on the association of this cytokine with hepatic schistosomiasis infection and liver disease in a context of mixed infection. This study therefore aimed at investigating the association between plasma levels of IL-33, infection status and liver fibrosis profiles in school children with S. mansoni infection alone or associated with malaria, hepatitis B or hepatitis C.…”

Section: Introductionmentioning

confidence: 99%

Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon

et al. 2019

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Background: This study aimed to investigate the association of plasma levels of IL-33, a mucosal alarmin known to elicit type-2 immunity, with infection and liver fibrosis profiles of school children from an endemic area for Schistosoma mansoni, malaria and hepatitis (B & C) in rural Cameroon.Methods: A cross-sectional study enrolling schoolchildren from 5 public schools was conducted. Single schistosomiasis, malaria and hepatitis infections or co-infections were assessed by kato katz, microscopy, and rapid diagnostic tests, respectively. Hepatic fibrosis was assessed by ultrasound according to WHO Niamey guidelines and plasma levels of Interleukin 33 were determined by ELISA. All statistics were performed using R studio software.Principal findings: We found a prevalence of 13.5% (37/275), 18.2% (50/275), and 8% (22/275), respectively for schistosomiasis, malaria and hepatitis (B or C) single infections. Only 7.6% (21/275) of co-infections were reported. Although Plasma IL-33 showed a minimal negative risk for schistosomiasis infection (AOR 0.99; 95% CI 0.97–1.01), S. mansoni infected participants had lower levels of plasma IL-33 (p = 0.003) which decreased significantly as eggs burdens increased (p = 0.01) with a negative Pearson coefficient of r = −0.22. Hepatic fibrosis occurred in 47.3% (130/275) of our study population independently from plasma levels of IL-33 (AOR 1.00; 95% CI 0.99–1.01).Conclusion/Significance: Our data failed to show an association between plasma IL-33 levels and liver disease but convincingly report on a negative association between plasma IL-33 levels and schistosomiasis infection and egg burden in school children from a polyparasitic schistosomiasis endemic area.

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The role of ST2 and ST2 genetic variants in schistosomiasis

Cited by 14 publications

References 43 publications

Host Regulators of Liver Fibrosis During Human Schistosomiasis

Host Regulators of Liver Fibrosis During Human Schistosomiasis

Global issues in allergy and immunology: Parasitic infections and allergy

Negative Association of Interleukin-33 Plasma Levels and Schistosomiasis Infection in a Site of Polyparasitism in Rural Cameroon

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