The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques

Akarsu, Süleyman; Göde, Funda; Işık, Ahmet Zeki; Dikmen, Z. Günnur; Tekindal, Mustafa Agâh

doi:10.1007/s10815-017-0882-x

Cited by 34 publications

(20 citation statements)

References 31 publications

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“…Similarly, levels resulted in significantly enhanced grading I–II versus grading III–IV embryos. This data was recently confirmed by Akarsu S. et al [ 21 ] and could highlight a role of CoQ10 in protecting follicular lipoproteins from oxidation, preserving their functionality. Moreover, different studies have pointed out the ability of Coenzyme Q10 supplementation, 600 mg/day for 60 days, in improving the ovarian response in women with decreased ovarian reserve [ 22 , 23 ], consistently pointing out at treatment, leading to an improved responsiveness to follicular pre-stimulation in terms of lower gonadotropin requirement during IVF.…”

Section: Introductionsupporting

confidence: 80%

CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity

et al. 2018

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Background: The target of the reduced fecundity with aging is the oocyte. The follicular fluid and its components are strongly linked with the environment of the maturing oocyte. The aim of the present study was to evaluate CoQ10 bioavailability in follicular fluids after oral supplementation and its possible implication in oocyte maturation. Methods: Fifteen female partners of infertile couples, aged 31–46, undergoing IVF-ET and taking 200 mg/day oral CoQ10 were compared to unsupplemented patients. CoQ10 content, its oxidative status and total antioxidant capacity were evaluated also in relation to oocyte maturation indexes. Results: CoQ10 supplementation produced a significant increase in follicular content and a significant improvement of its oxidative status. Follicular fluid total antioxidant capacity highlighted a significant decrease in patients supplemented with CoQ10, specially in women >35 years. CoQ10 supplementation was associated with a significant decrease in total antioxidant capacity of fluid from follicles containing mature oocyte, moreover CoQ10 oxidative status was also significantly reduced but in follicles containing immature oocyte. Conclusions: Our observation leads to the hypothesis that the oral supplementation of CoQ10 may improve follicular fluid oxidative metabolism and oocyte quality, specially in over 35-year-old women.

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Section: Introductionsupporting

confidence: 80%

CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity

et al. 2018

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“…Treatment with CoQ10 increased the number of ovulated oocytes and reduced ROS in oocytes to the levels observed in young animals, indicating this is an effective strategy to reverse the effect of reproductive ageing [ 33 ]. In humans, levels of CoQ10 in the follicular fluid positively correlated with oocyte maturation, embryo grade and pregnancy rate in women undergoing ART [ 34 , 35 ]. While oocyte appears to be the main target of CoQ10, it remains unclear whether anti-oxidant treatment also improves uterine environment.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial

Nisenblat

et al. 2018

Reprod Biol Endocrinol

157

148

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BackgroundManagement of women with reduced ovarian reserve or poor ovarian response (POR) to stimulation is one of the major challenges in reproductive medicine. The primary causes of POR remain elusive and oxidative stress was proposed as one of the important contributors. It has been suggested that focus on the specific subpopulations within heterogeneous group of poor responders could assist in evaluating optimal management strategies for these patients. This study investigated the effect of anti-oxidant treatment with coenzyme Q10 (CoQ10) on ovarian response and embryo quality in young low-prognosis patients with POR.MethodsThis prospective, randomized controlled study included 186 consecutive patients with POR stratified according to the POSEIDON classification group 3 (age < 35, poor ovarian reserve parameters). The participants were randomized to the CoQ10 pre-treatment for 60 days preceding IVF-ICSI cycle or no pre-treatment. The number of high quality embryos was a primary outcome measure.ResultsA total of 169 participants were evaluated (76 treated with CoQ10 and 93 controls); 17 women were excluded due to low compliance with CoQ10 administration. The baseline demographic and clinical characteristics were comparable between the groups. CoQ10 pretreatment resulted in significantly lower gonadotrophin requirements and higher peak E2 levels. Women in CoQ10 group had increased number of retrieved oocytes (4, IQR 2–5), higher fertilization rate (67.49%) and more high-quality embryos (1, IQR 0–2); p < 0.05. Significantly less women treated with CoQ10 had cancelled embryo transfer because of poor embryo development than controls (8.33% vs. 22.89%, p = 0.04) and more women from treatment group had available cryopreserved embryos (18.42% vs. 4.3%, p = 0.012). The clinical pregnancy and live birth rates per embryo transfer and per one complete stimulation cycle tended to be higher in CoQ10 group but did not achieve statistical significance.ConclusionPretreatment with CoQ10 improves ovarian response to stimulation and embryological parameters in young women with poor ovarian reserve in IVF-ICSI cycles. Further work is required to determine whether there is an effect on clinical treatment endpoints.

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“…Concerning the maternal aging, a clinical investigation strengthened the beneficial properties of CoQ10 demonstrated in animal studies on this matter. Oral CoQ10 administration (200 mg/day in two daily administration, for 30 days) improved the follicular fluid oxidative metabolism and the oocyte quality in over 35-year-old-women [ 67 ]. A controlled randomized trial with an oral CoQ10 supplementation of 600 mg for two months and for up to three cycles (if pregnancy did not occur) resulted in a lower rate of aneuploidy in post-meiotic oocytes retrieved from aged women [ 68 ], but no significant differences in IVF outcomes were detected between the CoQ10 and placebo groups [ 68 ].…”

Section: Agents Consideredmentioning

confidence: 99%

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

Budani

Tiboni

2020

Antioxidants

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For most infertile couples, in vitro fertilization (IVF) represents the only chance to conceive. Given the limited success of IVF procedures, novel approaches are continuously tested with the aim of improving IVF outcomes. Growing attention is devoted today to the potential benefit of natural antioxidants in the optimization of infertility treatments. This review summarizes current data in this context, focusing on both experimental studies on oocytes/embryos and clinical trials on antioxidants supplementation. Based on information gained from experimental studies, antioxidant supplementation may have beneficial effects on IVF outcomes in terms of quality and cryotolerance of in vitro produced embryos, together with positive effects on in vitro maturation oocytes and on early embryonic development. Unfortunately, from the clinical side, there is a paucity of evidence favoring the protective qualities of antioxidants. Among the antioxidants considered, coenzyme Q10 may be regarded as one of the most promising for its positive role in rescuing the oxidative stress-induced damages, but further data are needed. It is concluded that further trials are necessary to characterize the potential clinical value of antioxidants in IVF treatments.

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The association between coenzyme Q10 concentrations in follicular fluid with embryo morphokinetics and pregnancy rate in assisted reproductive techniques

Abstract: High follicular fluid CoQ10 level is associated with optimal embryo morphokinetic parameters and higher pregnancy rates.

Cited by 34 publications

References 31 publications

CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity

CoQ10 Supplementation in Patients Undergoing IVF-ET: The Relationship with Follicular Fluid Content and Oocyte Maturity

Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial

Effects of Supplementation with Natural Antioxidants on Oocytes and Preimplantation Embryos

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