Liver transplantation: a life-saving procedure following amatoxin mushroom poisoning

Ma, KW; Chok, Kenneth SH; Chan, C. K.; Dai, Wing Chiu; Sin, SL; Lau, FL; Chan, SC; Lo, CM

doi:10.12809/hkmj154616

Cited by 8 publications

(4 citation statements)

References 6 publications

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“…In the present study, the most common symptoms of fungal poisoning were gastrointestinal symptoms, which is consistent with the results of studies by Soltaninejad 2018), the most common manifestations of fungal poisoning were hepatic manifestations [21,25,26]. In the study of Vo et al (2017), the gastrointestinal and hepatic systems had the highest rate of involvement [8].…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, the most common symptoms of fungal poisoning were gastrointestinal symptoms, which is consistent with the results of studies by Soltaninejad et al (2019), Khatir et al (2020), Badsar et al (2013), and Schmutz et al (2018) [ 2 , 5 , 23 , 24 ]. However, in the studies of Trakulsrichai et al (2017), Ma et al (2017), and Wen et al (2018), the most common manifestations of fungal poisoning were hepatic manifestations [ 21 , 25 , 26 ]. In the study of Vo et al (2017), the gastrointestinal and hepatic systems had the highest rate of involvement [ 8 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, the cause of poisoning was Amanita virosa in only 10% of cases and mountain fungi in 90%, in general. In studies conducted in China, the United States, and Iran, the type of mushroom consumed was different [6,[20][21][22]. In this regard, during the epidemic of fungal poisoning in Iran (2018), three types of fungi named Lepiota brunneioncarnata, Hypholoma fascicalare, and Coprinopsis atramentaria were introduced [2].…”

Section: Discussionmentioning

confidence: 99%

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Demographic, clinical, and laboratory findings of mushroom-poisoned patients in Kermanshah province, west of Iran

Janatolmakan

Ganji

Ahmadi-Jouybari

et al. 2022

BMC Pharmacol Toxicol

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Background Mushroom poisoning can cause gastrointestinal, renal, and hepatic symptoms and even death. This descriptive study examined the demographic, clinical, and laboratory findings of patients with fungal poisoning, a type of fungus causing the poisoning, and the incidence and mortality rates of fungal poisoning in Kermanshah province, western Iran, from 2014 to 2018. Methods The medical records of 193 patients with mushroom poisoning from 2014 to 2018 were evaluated. The liver and kidney function tests, electrolytes, abdominal and pelvic ultrasound, chest x-ray, coagulation tests, and coagulation factors (fibrinogen, prothrombin) were assessed. Data were collected from the medical records of patients admitted to the Poisoning Center of Imam Khomeini Hospital in Kermanshah, Iran using a researcher-made checklist. Data were analyzed by SPSS (version 16) using descriptive statistics, including mean, standard deviation, and frequency distribution tables. Trend analysis for proportion was done by chi-square statistics in STATA-14 software (ptrend command). Results Of cases, ‌51.3% were male, 92.6% were city dwellers, 38.3% were aged 21–40 years, and 92.5% were poisoned during the spring. The fungus that caused poisoning was Amanita virosa. The gastrointestinal, nervous, and visual systems were the most common systems involved. The most common gastrointestinal symptoms included nausea and vomiting (72.0%) and abdominal pain (71.0%). Vertigo (11.9%) and headache (9.3%) were the most common neurological symptoms. The most common visual manifestation was blurred vision (7.8%). Of cases, 23.7% had metabolic acidosis. The increased alkaline phosphatase level was the most common liver disorder in 98.7% of the cases. Increased blood urea nitrogen and creatinine levels were also reported in 21.0% and 17.7% of the cases, respectively. The serum lactic dehydrogenase and creatine phosphokinase levels also increased in 99.3% and 30.2% of the patients, respectively. The mortality rate was 1.6% (n = 3). Conclusion The fungal poisoning diagnosis should always be considered in young patients referred to the emergency department with gastrointestinal complaints, a history of consuming wild self-picked mushrooms, and high liver and kidney test values. Since most fungal poisonings occur in the spring, it is necessary to inform the community of the dangers of consuming self-picked wild mushrooms, especially in this season.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Demographic, clinical, and laboratory findings of mushroom-poisoned patients in Kermanshah province, west of Iran

Janatolmakan

Ganji

Ahmadi-Jouybari

et al. 2022

BMC Pharmacol Toxicol

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“…Plasma transfusion should be avoided to preserve the natural course of coagulation tests that are key prognostic criteria . Total LT which was life‐saving in numerous patients has to be decided by hepatologists and the liver transplant surgeon taking into account a possible 2‐4 days delay often required for the availability of a liver graft. Finally, early admission to a liver unit with LT facilities offers the opportunity to contemplate early, in patients younger than 50 years and at risk of ALF but without multiorgan failure, the feasibility of auxiliary LT that could obviate life‐long immunosuppression tied to a total LT. Auxiliary LT was successfully performed in a few patients …”

Section: Progression Of Acute Liver Disease In 32 Hospitalized Patienmentioning

confidence: 99%

Amatoxin poisoning: Immediate transfer to intensive care or liver unit of patients at early risk of severe acute liver injury

Bernuau

Francoz

Durand

2019

Liver International

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The overall rate (OR) of both death and emergency liver transplantation (LT) in patients with amatoxin containing mushroom poisoning (ACMP) is unequal according to their selection. In three series of more than 100 unselected patients each, and gathered over 14-35 years 1,2 in pharmacology 1 or toxicology 2 departments, this OR was lower than 14%, 1,2 but was significantly increased if the only patients most severely affected at admission are considered. 1,2 By comparison, the OR of death and LT ranged from 15% to 44% in François Durand

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Malicious Mushrooms

Iskander¹,

Marzouk²,

Iskander³

et al. 2023

Gastro Hep Advances

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Liver transplantation: a life-saving procedure following amatoxin mushroom poisoning

Cited by 8 publications

References 6 publications

Demographic, clinical, and laboratory findings of mushroom-poisoned patients in Kermanshah province, west of Iran

Demographic, clinical, and laboratory findings of mushroom-poisoned patients in Kermanshah province, west of Iran

Amatoxin poisoning: Immediate transfer to intensive care or liver unit of patients at early risk of severe acute liver injury

Malicious Mushrooms

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