Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression

Bergfeld, Isidoor O.; Mantione, Mariska; Hoogendoorn, Mechteld L.C.; Ruhé, Henricus G.; Horst, Ferdinand; Notten, Peter; Laarhoven, Jan van; Munckhof, Pepijn van den; Beute, Guus; Schuurman, P. Richard; Denys, Damiaan

doi:10.1017/s0033291717000113

Cited by 33 publications

(23 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…88 No permanent impact (either positive or negative) on cognition was observed in a posterior study with the same sample. 89 A double-blind crossover trial with seven TRD patients investigated the stimulation in either the anterior limb of the internal capsule/BNST or in the ITP. All of the patients participated in the follow-ups for at least 3 years, but some were followed-up up to 8 years after the procedure.…”

Section: Resultsmentioning

confidence: 99%

Deep Brain Stimulation for the Treatment of Resistant Depression: Systematic Review of the Literature

2019

View full text Add to dashboard Cite

Depression is the leading cause of disability worldwide, and it is related to high suicide rates. Furthermore, a great number of patients do not respond to any of the available treatments. Deep brain stimulation (DBS), a versatile technology with expanding indications, is considered a potential treatment for resistant depression. However, in over 10 years of clinical research, its efficacy has not been completely proven. Although new trials using DBS for treatment-resistant depression keep emerging, two of the three Level I evidence-based studies recently conducted have not provided conclusive data. Methodological limitations and major biases have compromised the obtention of clearer results. In this systematic review of the literature, we intend to critically assess the clinical trials performed in this field.

show abstract

Section: Resultsmentioning

confidence: 99%

Deep Brain Stimulation for the Treatment of Resistant Depression: Systematic Review of the Literature

2019

View full text Add to dashboard Cite

show abstract

“…While open label studies of VC/VS demonstrated promising results (39), a previous randomized-controlled RECLAIM study on the subject was halted early due to lack of significant difference between the two arms after 30 patients had been enrolled (40). Interestingly, in a RCT of 25 patients with bilateral VC/VS DBS in the Netherlands, discontinuation of therapy during the crossover phase resulted in reemergence of symptoms (41). Fifty percent response and 30% remission was noted in open-label longterm follow-up of 28 patients receiving subcallosal cingulate stimulation (42).…”

Section: Depressionmentioning

confidence: 99%

Deep Brain Stimulation for Obsessive-Compulsive Disorder: Real World Experience Post-FDA-Humanitarian Use Device Approval

et al. 2021

View full text Add to dashboard Cite

Background: While case series have established the efficacy of deep brain stimulation (DBS) in treating obsessive-compulsive disorder (OCD), it has been our experience that few OCD patients present without comorbidities that affect outcomes associated with DBS treatment. Here we present our experience with DBS therapy for OCD in patients who all have comorbid disease, together with the results of our programming strategies.Methods: For this case series, we assessed five patients who underwent ventral capsule/ventral striatum (VC/VS) DBS for OCD between 2015 and 2019 at the University of Colorado Hospital. Every patient in this cohort exhibited comorbidities, including substance use disorders, eating disorder, tic disorder, and autism spectrum disorder. We conducted an IRB-approved, retrospective study of programming modifications and treatment response over the course of DBS therapy.Results: In addition to patients' subjective reports of improvement, we observed significant improvement in the Yale-Brown Obsessive-Compulsive Scale (44%), the Montgomery-Asberg Depression Rating Scale (53%), the Quality of Life Enjoyment and Satisfaction Questionnaire (27%), and the Hamilton Anxiety Rating scales (34.9%) following DBS. With respect to co-morbid disease, there was a significant improvement in a patient with tic disorder's Total Tic Severity Score (TTSS) (p = 0.005).Conclusions: DBS remains an efficacious tool for the treatment of OCD, even in patients with significant comorbidities in whom DBS has not previously been investigated. Efficacious treatment results not only from the accurate placement of the electrodes by the surgeon but also from programming by the psychiatrist.

show abstract

“…DBS has been widely used, particularly for Parkinson’s disease, for over 30 years. Increasingly over the last decade, DBS has been applied to the treatment of psychiatric disorders including treatment-resistant depression ( 14 – 17 ), obsessive compulsive disorder (OCD) ( 18 , 19 ) and addictions ( 20 ). The US Food and Drug Administration approved a humanitarian device exemption for DBS in the treatment of severe OCD in 2009.…”

Section: Introductionmentioning

confidence: 99%

Study Protocol: Using Deep-Brain Stimulation, Multimodal Neuroimaging and Neuroethics to Understand and Treat Severe Enduring Anorexia Nervosa

2018

View full text Add to dashboard Cite

BackgroundResearch suggests that altered eating and the pursuit of thinness in anorexia nervosa (AN) are, in part, a consequence of aberrant reward circuitry. The neural circuits involved in reward processing and compulsivity overlap significantly, and this has been suggested as a transdiagnostic factor underpinning obsessive compulsive disorder, addictions and eating disorders. The nucleus accumbens (NAcc) is central to both reward processing and compulsivity. In previous studies, deep-brain stimulation (DBS) to the NAcc has been shown to result in neural and symptomatic improvement in both obsessive compulsive disorder and addictions. Moreover, in rats, DBS to the NAcc medial shell increases food intake. We hypothesise that this treatment may be of benefit in severe and enduring anorexia nervosa (SE-AN), but first, feasibility and ethical standards need to be established. The aims of this study are as follows: (1) to provide feasibility and preliminary efficacy data on DBS to the NAcc as a treatment for SE-AN; (2) to assess any subsequent neural changes and (3) to develop a neuroethical gold standard to guide applications of this treatment.MethodThis is a longitudinal study of six individuals with SE-AN of >7 years. It includes an integrated neuroethical sub-study. DBS will be applied to the NAcc and we will track the mechanisms underpinning AN using magnetoelectroencephalography, neuropsychological and behavioural measures. Serial measures will be taken on each intensively studied patient, pre- and post-DBS system insertion. This will allow elucidation of the processes involved in symptomatic change over a 15-month period, which includes a double-blind crossover phase of stimulator on/off.DiscussionNovel, empirical treatments for SE-AN are urgently required due to high morbidity and mortality costs. If feasible and effective, DBS to the NAcc could be game-changing in the management of this condition. A neuroethical gold standard is crucial to optimally underpin such treatment development.Clinical Trial RegistrationThe study is ongoing and registered with , , 22 July, 2013. It has full ethical and HRA approval (Project ID 128658).

show abstract

Impact of deep brain stimulation of the ventral anterior limb of the internal capsule on cognition in depression

Abstract: vALIC DBS neither has a lasting positive nor negative impact on cognition in TRD patients. DBS surgery might have a temporary negative effect on verbal memory.

Cited by 33 publications

References 31 publications

Deep Brain Stimulation for the Treatment of Resistant Depression: Systematic Review of the Literature

Deep Brain Stimulation for the Treatment of Resistant Depression: Systematic Review of the Literature

Deep Brain Stimulation for Obsessive-Compulsive Disorder: Real World Experience Post-FDA-Humanitarian Use Device Approval

Study Protocol: Using Deep-Brain Stimulation, Multimodal Neuroimaging and Neuroethics to Understand and Treat Severe Enduring Anorexia Nervosa

Contact Info

Product

Resources

About