The Transcription Factor MYB29 Is a Regulator of <i>ALTERNATIVE OXIDASE1a</i>

Zhang, Xinhua; Ivanova, Aneta; Vandepoele, Klaas; Radomiljac, Jordan D.; Velde, Jan Van de; Berkowitz, Oliver; Willems, Patrick J.; Xu, Yue; Ng, Sophia; Aken, Olivier Van; Duncan, Owen; Zhang, Botao; Storme, Véronique; Chan, Kai Xun; Vaneechoutte, Dries; Pogson, Barry J.; Breusegem, Frank Van; Whelan, James; Clercq, Inge De

doi:10.1104/pp.16.01494

Cited by 47 publications

(27 citation statements)

References 139 publications

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“…A positive regulator of glucosinolate metabolism in Arabidopsis, MYB29, has been previously shown to be a negative regulator of AOX expression (Zhang et al, 2017), and this may account for the reduction of AOX observed in the dgs1-1 lines ( Figure 5A). This supports the suggestion that there is an antagonistic relationship in the induction of glucosinolate metabolism and AOX (Zhang et al, 2017), with the former favored in the dgs1-1 lines. Glucosinolate biosynthesis is also regulated by jasmonic acid, and there is an antagonistic interaction between the jasmonic and salicylic acid hormone signaling pathways in Arabidopsis (Thaler et al, 2012).…”

Section: Discussionmentioning

confidence: 89%

“…Upregulation of glucosinolate biosynthesis and metabolism has been linked to responses to drought stress (Eom et al, 2018). A positive regulator of glucosinolate metabolism in Arabidopsis, MYB29, has been previously shown to be a negative regulator of AOX expression (Zhang et al, 2017), and this may account for the reduction of AOX observed in the dgs1-1 lines ( Figure 5A). This supports the suggestion that there is an antagonistic relationship in the induction of glucosinolate metabolism and AOX (Zhang et al, 2017), with the former favored in the dgs1-1 lines.…”

Section: Discussionmentioning

confidence: 98%

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Arabidopsis DGD1 SUPPRESSOR1 Is a Subunit of the Mitochondrial Contact Site and Cristae Organizing System and Affects Mitochondrial Biogenesis

Lavell

Meng

et al. 2019

The Plant Cell

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Mitochondrial and plastid biogenesis requires the biosynthesis and assembly of proteins, nucleic acids, and lipids. In Arabidopsis (Arabidopsis thaliana), the mitochondrial outer membrane protein DGD1 SUPPRESSOR1 (DGS1) is part of a large multi-subunit protein complex that contains the mitochondrial contact site and cristae organizing system 60-kD subunit, the translocase of outer mitochondrial membrane 40-kD subunit (TOM40), the TOM20s, and the Rieske FeS protein. A point mutation in DGS1, dgs1-1, altered the stability and protease accessibility of this complex. This altered mitochondrial biogenesis, mitochondrial size, lipid content and composition, protein import, and respiratory capacity. Whole plant physiology was affected in the dgs1-1 mutant as evidenced by tolerance to imposed drought stress and altered transcriptional responses of markers of mitochondrial retrograde signaling. Putative orthologs of Arabidopsis DGS1 are conserved in eukaryotes, including the Nuclear Control of ATP Synthase2 (NCA2) protein in yeast (Saccharomyces cerevisiae), but lost in Metazoa. The genes encoding DGS1 and NCA2 are part of a similar coexpression network including genes encoding proteins involved in mitochondrial fission, morphology, and lipid homeostasis. Thus, DGS1 links mitochondrial protein and lipid import with cellular lipid homeostasis and whole plant stress responses.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 98%

Arabidopsis DGD1 SUPPRESSOR1 Is a Subunit of the Mitochondrial Contact Site and Cristae Organizing System and Affects Mitochondrial Biogenesis

Lavell

Meng

et al. 2019

The Plant Cell

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“…Recently, Zhang et al (2017a) identified MYB DO-MAIN PROTEIN29/RAO7 as an additional transcription factor that has a negative, albeit indirect, regulatory impact on downstream genes related to mitochondrial stress, including AOX1a, but notably also WRKY40 and ANAC053. Since WRKY40 in turn regulates expression of ABI4 (Liu et al, 2012b) it appears that the transcription factors in retrograde signaling form expression networks.…”

Section: Proteins Regulating Nuclear Transcription In Mitochondrial Smentioning

confidence: 99%

Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants

et al. 2018

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ORCID IDs: 0000-0001-5369-7911 (S.W.); 0000-0003-4024-968X (O.V.A.); 0000-0003-0796-8308 (M.S.).Cells of complex organisms typically rely on mitochondria for energy provision. The amount of energy required to sustain cellular activity can vary strongly depending on external conditions. Vice versa, constraints on respiratory activity due to metabolic status or stress insult require mitochondrial signaling to coordinate cellular physiology with the function of the organelle. In this update, we review recent insights into plant mitochondrial energy signaling in the light of their significance to stress acclimation. First, we focus on the characteristic adjustments of the nuclear transcriptome that occur after pharmacological inhibition of the mitochondrial electron transport chain as the output of mitochondrial retrograde signaling. Second, we discuss the proteins that have recently been identified as regulators of the transcript responses and the emerging picture of their action as a signaling network. We then pose the question of how well our current models of inducing mitochondrial dysfunction relate to conditions that plants face naturally. We reason that low-oxygen stress shows striking similarities with electron transport inhibitors with respect to their impact on mitochondrial energy physiology upstream, as well as the cellular transcriptomic response. Finally, we highlight and discuss changes in mitochondrial physiology that are common to both stimuli as candidates for upstream signals. The aim of this update is to better define the physiological context in which mitochondrial signaling operates to provide new directions for future research. RESPONSES TO MITOCHONDRIAL ENERGY SIGNALING AT THE TRANSCRIPT LEVEL

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“…In Arabidopsis thaliana , great progress has been made to identify a set of nuclear genes whose expression is responsive to mitochondrial dysfunction (Schwarzländer et al ). Proteins controlling the transcriptional response of such genes have been identified (Giraud et al , Geisler et al , Vanderauwera et al , De Clercq et al , Van Aken et al , Ng et al , , Zhang et al ), and it has been shown that the transcriptional changes result in acclimation responses that benefit the plant (Van Aken et al ). Hence, these stress response pathways have become an important model for the study of retrograde (mitochondrion‐to‐nucleus) signaling (Ng et al , Wagner et al , Wang et al ).…”

Section: Introductionmentioning

confidence: 99%

Signaling interactions between mitochondria and chloroplasts in Nicotiana tabacum leaf

Alber

Vanlerberghe

2019

Physiologia Plantarum

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Research has begun to elucidate the signal transduction pathway(s) that control cellular responses to changes in mitochondrial status. Important tools in such studies are chemical inhibitors used to initiate mitochondrial dysfunction. This study compares the effect of different inhibitors and treatment conditions on the transcript amount of nuclear genes specifically responsive to mitochondrial dysfunction in leaf of Nicotiana tabacum L. cv. Petit Havana. The Complex III inhibitors antimycin A (AA) and myxothiazol (MYXO), and the Complex V inhibitor oligomycin (OLIGO), each increased the transcript amount of the mitochondrial dysfunction genes. Transcript responses to OLIGO were greater during treatment in the dark than in the light, and the dark treatment resulted in cell death. In the dark, transcript responses to AA and MYXO were similar to one another, despite MYXO leading to cell death. In the light, transcript responses to AA and MYXO diverged, despite cell viability remaining high with either inhibitor. This divergent response may be due to differential signaling from the chloroplast because only AA also inhibited cyclic electron transport, resulting in a strong acceptor‐side limitation in photosystem I. In the light, chemical inhibition of chloroplast electron transport reduced transcript responses to AA, while having no effect on the response to MYXO, and increasing the response to OLIGO. Hence, when studying mitochondrial dysfunction signaling, different inhibitor and treatment combinations differentially affect linked processes (e.g. chloroplast function and cell fate) that then contribute to measured responses. Therefore, inhibitor and treatment conditions should be chosen to align with specific study goals.

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The Transcription Factor MYB29 Is a Regulator of ALTERNATIVE OXIDASE1a

Cited by 47 publications

References 139 publications

Arabidopsis DGD1 SUPPRESSOR1 Is a Subunit of the Mitochondrial Contact Site and Cristae Organizing System and Affects Mitochondrial Biogenesis

Arabidopsis DGD1 SUPPRESSOR1 Is a Subunit of the Mitochondrial Contact Site and Cristae Organizing System and Affects Mitochondrial Biogenesis

Mitochondrial Energy Signaling and Its Role in the Low-Oxygen Stress Response of Plants

Signaling interactions between mitochondria and chloroplasts in Nicotiana tabacum leaf

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