Prevalence of Adverse Drug Reactions to Highly Active Antiretroviral Therapy (HAART) among HIV Positive Patients in Imam Khomeini Hospital of Tehran, Iran

Koochak, Hamid Emadi; Babaii, Azita; Pourdast, Alia; Golrokhy, Raheleh; Rasoolinejad, Mehrnaz; Khodaei, Sepideh; Moghadam, Saeed R J; Taheri, Reza; Mehraeen, Esmaeil

doi:10.2174/1871526517666170117111350

Cited by 15 publications

(12 citation statements)

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“…Adverse effects of ARVs are related to each compound as well as to the genetic factors of the host and the patient's lifestyle. In a study by Golrokhy et al (Golrokhy et al, 2017 ) 94% of ART exposed patients exhibited adverse effects. The discomfort created by various side effects is an important factor that diminishes the adherence or leads to treatment discontinuation.…”

Section: Barriers To Artmentioning

confidence: 99%

Improving the Adherence to Antiretroviral Therapy, a Difficult but Essential Task for a Successful HIV Treatment—Clinical Points of View and Practical Considerations

Iacob²,

2017

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HIV infection is responsible for one the most devastating human pandemics. The advent of antiretroviral therapy has changed the course of the pandemic and saved millions of lives. Complex therapeutic regimens have been introduced since 1996 and have contributed to the transformation of HIV infection into a treatable chronic diseases. New types of potent antiretrovirals and their combinations, including “once daily” treatment, have simplified the regimens and diminished side effects. Nevertheless the adherence to antiretroviral therapy remains unsatisfactory and varies between 27 and 80% across different population in various studies, compared with the required level of 95%. The lack of adherence to antiretroviral therapy is a multi-factorial and dynamic process which raises considerable difficulties for long-term follow-up. Current solutions to this problem are complex. These should be applied by a multidisciplinary team and should take into account key features related to both the individual and social factors as well as to the population to whom it belongs (children, teenagers, elderly, marginalized population like drug users, incarcerated patients, sex workers, etc.). Importantly, adherence should continue to be monitored even in patients known to be compliant. In case of subsequent failure the team should identify the reasons for non-adherence and apply the appropriate methods. Where usual methods have no chance of success, a coordinated package of services also known as “harm reduction” can be offered in order to reduce the risks of transmission. The current article analyses the concept of adherence to antiretroviral therapy, the shortcomings of this medication and the methods that can be applied in practice to increase adherence. Emphasis is placed on the analysis of groups at high risk for HIV infection that currently represent the spearhead with which the HIV pandemic is spreading.

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Section: Barriers To Artmentioning

confidence: 99%

Improving the Adherence to Antiretroviral Therapy, a Difficult but Essential Task for a Successful HIV Treatment—Clinical Points of View and Practical Considerations

Iacob²,

2017

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“…[13] Several studies have also reported from Iran on epidemiological characteristics (occurrence, prevalence, or incidence) of DRPs, especially ADRs, which have emphasized on the active role of clinical pharmacists in decreasing these types of problem. [14151617181920212223] However, it should be noted that all of these studies have been conducted by clinical pharmacists themselves and in their employment centers, which may indicate a source of probable bias.…”

Section: Introductionmentioning

confidence: 99%

The responsibility of clinical pharmacists for the safety of medication use in hospitalized children: A Middle Eastern experience

et al. 2019

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Objective: We aimed to detect and report the frequency of occurrence of drug-related problems (DRPs) in a Middle Eastern University Children's Hospital (Isfahan, Iran) and classify them in terms of their nature and cause to clarify the responsibility of clinical pharmacists for the safe utilization of medications in hospitalized children. Methods: In this cross-sectional study which was carried out in Imam Hossein Children's University Hospital affiliated with Isfahan University of Medical Sciences (Isfahan, Iran) from September 2017 to May 2018, DRPs during the hospitalization of pediatric patients in three medical wards, the pediatric intensive care unit, and two neonatal intensive care units were detected and identified concurrently with the treatment process using Pharmaceutical Care Network of Europe data gathering form for DRPs v. 8.01. All cases were verified and validated in a professional focus group before documentation. Findings: We detected 427 DRPs in 201 out of 250 randomly included hospitalized children in which 86% of them were directly reported by the hospital's clinical pharmacist. The highest frequency of DRPs (47.3%) was observed in the age range of 1 month–2 years. Safety of treatment was the most frequently reported as the nature of the problem (43.5%), followed by effectiveness issues (36.8%). The most frequent cause of DRPs was dose selection issues (34.2%), followed by drug-type selection (25.5%), and unavailability of appropriate dosage forms (13.6%). Ninety-eight interventions were proposed by the clinical pharmacist, in which 59.2% of them were accepted. Conclusion: This study confirms the necessity for the active role of clinical pharmacists before, during, and after drug therapy in hospitalized pediatric patients for the safety and proper utilization of drugs in this vulnerable population.

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“…Similarly, a cross-sectional survey in Iran from 2009 to 2010 conducted by [27] among 200 patients who were HIV positive to find out the prevalence of adverse drug reactions among them while they take their ART. The result showed that 188 of the participants experienced diverse side effects of ART which led to reduced adherence to therapy while some discontinued treatment.…”

Section: Resultsmentioning

confidence: 99%

Adverse Drug Effects and Non-Adherence to Antiretroviral Therapy in Nigeria: A Review

Okuku

Dan-Jumbo

2021

AJARR

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Objectives: This review aims to assess the link between adverse drug effects and non-adherence to antiretroviral therapy (ART) among people living with HIV/AIDS (PLWHA) in Nigeria. Methodology: Databases were searched namely PubMed, Web of science core collection, Science direct, Global Health (CABI) and MEDLINE. Fifteen (15) primary articles (studies carried out in Nigeria) met the inclusion criteria and were selected for the review. The primary articles selected for the review were analyzed and critiqued. Results: The articles selected for review showed that adverse drug effects is a barrier to adherence to ART. Conclusion: The review conclude that adverse drug effect is a barrier to adherence to ART among PLWHA in Nigeria and recommends patient education on side effects of ART, the need for regular exercises, eating healthy meals and the need for physicians to simplify the regimen with regards to the amount of medication to take and the timing.

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Prevalence of Adverse Drug Reactions to Highly Active Antiretroviral Therapy (HAART) among HIV Positive Patients in Imam Khomeini Hospital of Tehran, Iran

Abstract: Given the high prevalence of adverse drug reactions among HIV positive patients taking antiretroviral therapy (ART) in this study, clinicians should be aware of ADRs at the initiation of ART as complications can affect patients' adherence to the therapy.

Cited by 15 publications

References 0 publications

Improving the Adherence to Antiretroviral Therapy, a Difficult but Essential Task for a Successful HIV Treatment—Clinical Points of View and Practical Considerations

Improving the Adherence to Antiretroviral Therapy, a Difficult but Essential Task for a Successful HIV Treatment—Clinical Points of View and Practical Considerations

The responsibility of clinical pharmacists for the safety of medication use in hospitalized children: A Middle Eastern experience

Adverse Drug Effects and Non-Adherence to Antiretroviral Therapy in Nigeria: A Review

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