Influential Factors of the Indeterminate Results Tested by QuantiFERON-TB Gold In-Tube (QFT-IT) Assay for Diagnosing TB Infection in HIV-Infected Patients

Dai, Qinghai; Qiao, Kunyan; Zhang, Shitian; Huo, Zhixiao; Wang, Jingyu; Cui, Qi; Du, Yanan; Lü, Wei; Hou, Wanwan

doi:10.7754/clin.lab.2016.160209

Cited by 2 publications

(2 citation statements)

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“…However, high SLEDAI scores seemed not related with a high proportion of indeterminate results, and this differs from some studies [20][21][22][23][24]. Other previous researches showed that CD4+ T cell count, lymphocyte count, and lymphocyte percentage were influencing factors for the indeterminate results of QFT-GIT in HIV and immunosuppressive people [25,26]. Glucocorticoid therapy is also another reason for the indeterminate outcome of QFT [20,27,28].…”

Section: Discussionmentioning

confidence: 89%

Performance of LTBI Screening in Patients with Rheumatic Diseases Using Two Different Interferon-Gamma Releasing Assays

Zhang¹,

Zhang²,

Yang³

et al. 2022

Front. Biosci. (Landmark Ed)

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Background: To evaluate the concordance between QuantiFERON-TB Gold in-tube test (QFT-GIT) and T-SPOT.TB test (T-SPOT) for the screening of latent tuberculosis infection (LTBI) in patients with rheumatic diseases (RDs). Methods: Patients diagnosed as rheumatic diseases (RDs) with clinical indications for test of interferon gamma release test (IGRA) were prospectively recruited from 2019 to 2020. The consistency of QFT-GIT and T-SPOT was assessed by Kappa analysis and the factors associated with the indeterminate results were explored by multivariable logistic analysis. Results: A total of 108 patients with RDs were enrolled, including 64 patients with systemic lupus erythematosus (SLE) and 44 with inflammatory arthritis (26 with rheumatoid arthritis (RA) and 18 with ankylosing spondylitis (AS)). Poor concordance was confirmed between QFT-GIT and T-SPOT results in patients with SLE (K = 0.175, 95% confidence interval [95% CI] [-0.06, 0.40], p < 0.001), whereas concordance was moderate in patients with inflammatory arthritis (K = 0.539, 95% CI [0.11, 0.88], p < 0.001). Among SLE patients, the ratio of indeterminate results in detecting LTBI was significantly higher by QFT-GIT than by T-SPOT (18.8% vs. 4.7%, p = 0.013), while the statistical difference was not achieved in patients with inflammatory arthritis. The multivariable logistic analysis identified that the presence of lower lymphocyte counts (odds ratio [OR] = 0.81, 95% CI [0.68, 0.97], p = 0.020) was the independent predictor of an indeterminate result of the QFT-GIT in SLE patients. Conclusions: In patients with RDs, the result of screening of LTBI was more definitive by T-SPOT test than QFT, and the concordance was poor especially in the setting of SLE.

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Section: Discussionmentioning

confidence: 89%

Performance of LTBI Screening in Patients with Rheumatic Diseases Using Two Different Interferon-Gamma Releasing Assays

Zhang¹,

Zhang²,

Yang³

et al. 2022

Front. Biosci. (Landmark Ed)

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“…The rate of indeterminate results in the immunocompromised group was higher than that in the immunocompetent group in our study. The rate of indeterminate results was 7% in controls free from glucocorticoid and immunosuppressant treatment ( 28 ), but was up to 30% in patients with HIV and in those receiving high-dose corticosteroid therapy ( 29 , 30 ). Previous studies have found that lymphopenia, chronic renal disease, autoimmune disease, and chronic lung disease are independent predictive factors for indeterminate results from a QFT-GIT test ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

Comparison of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold-Plus in the Diagnosis of Mycobacterium tuberculosis Infections in Immunocompromised Patients: a Real-World Study

Yang

Zhou

et al. 2022

Microbiol Spectr

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This study evaluated the performance of QFT-GIT and QFT-Plus in the diagnosis of M. tuberculosis infection in immunocompromised patients and found that QFT-Plus may detect more LTBI than QFT-GIT does in patients receiving long-term immunosuppressant therapy. We believe that our study makes a significant contribution to the literature because it highlights the different diagnostic accuracies of QFT-GIT and QFT-Plus in different subpopulations of immunocompromised and immunocompetent patients.

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Influential Factors of the Indeterminate Results Tested by QuantiFERON-TB Gold In-Tube (QFT-IT) Assay for Diagnosing TB Infection in HIV-Infected Patients

Abstract: The QFT-IT could be a potential, simple, and feasible method for diagnosing and screening TB in HIV-infected patients. In addition, the CD4 T-cell count, the lymphocyte count, and the lymphocyte percentage were influential factors of the indeterminate results of QFT-IT.

Cited by 2 publications

References 0 publications

Performance of LTBI Screening in Patients with Rheumatic Diseases Using Two Different Interferon-Gamma Releasing Assays

Performance of LTBI Screening in Patients with Rheumatic Diseases Using Two Different Interferon-Gamma Releasing Assays

Comparison of QuantiFERON-TB Gold In-Tube and QuantiFERON-TB Gold-Plus in the Diagnosis of Mycobacterium tuberculosis Infections in Immunocompromised Patients: a Real-World Study

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