High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes

Støa, Eva Maria; Meling, Sondre; Nyhus, Lill-Katrin; Strømstad, Glenn; Mangerud, Karl Magnus; Helgerud, Jan; Bratland‐Sanda, Solfrid; Støren, Øyvind

doi:10.1007/s00421-017-3540-1

Cited by 81 publications

(106 citation statements)

References 62 publications

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“…Similarly, in the 12-week intervention studies that were similar to our study (25, 27, 57, 59, 61), no changes within the groups were reported as being statistically superior. The importance of these initial modest improvement in adiposity following a 12-week intervention must not be overlooked as a post-hoc analysis of the Look AHEAD study (64) reported that the overweight and obese T2D participants in their intensive lifestyle intervention group who lost 10% body weight in the first year of the study, had a 20% lower risk of their study's primary outcome (a composite of death from cardiovascular causes, non-fatal acute MI, non-fatal stroke or admission to hospital for angina).…”

Section: Discussionsupporting

confidence: 81%

“…Notwithstanding the RT component, our study was similar to prior studies comparing HIIT and MICT in people with T2D with regards to the 12-week intervention duration (25, 27, 57, 61) and the frequency of three HIIT sessions per week (25, 27, 56, 57, 61). Although the diverse application of the HIIT variables (i.e., intensity, duration and number of bouts) across all studies limit direct comparisons, our study's HIIT variables were comparable.…”

Section: Discussionsupporting

confidence: 65%

“…This finding is akin to seven of the eight prior HIIT and MICT comparison studies that reported similar improvements in HbA1c for both their intervention groups [(25, 27, 56–60)]. The remaining comparison study Støa et al (61) reported a greater significant change in HbA1c for HIIT, however, the authors did report that the greater effect may have been due to the significantly higher HbA1c level in their HIIT group ( P = 0.02) at baseline.…”

Section: Discussionsupporting

confidence: 60%

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High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes

et al. 2018

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We sought to determine the efficacy of 12 weeks high-intensity interval training (HIIT), compared to moderate-intensity continuous training (MICT) on glucose control, cardiometabolic risk and microvascular complication markers in men living with type 2 diabetes (T2D). Both modalities were combined with resistance training (RT). Additionally, the study aimed to determine the medium-term durability of effects. After a 12-week, thrice weekly, training intervention incorporating either MICT+RT (n = 11) or HIIT+RT (n = 12), the study concluded with a 6-month follow-up analysis. The middle-aged study participants were obese, had moderate duration T2D and were taking multiple medications including insulin, statins and beta-blockers. Participants, randomized via the method of minimization, performed MICT (progressing to 26-min at 55% maximum estimated workload [eWLmax]) or HIIT (progressing to two variations in which twelve 1-min bouts at 95% eWLmax interspersed with 1-min recovery bouts, alternated with eight 30-s bouts at 120% eWLmax interspersed with 2:15 min recovery bouts) under supervision at an exercise physiology facility. To account for fixed and random effects within the study sample, mixed-effect models were used to determine the significance of change following the intervention and follow-up phases and to evaluate group*time interactions. Beyond improvements in aerobic capacity (P < 0.001) for both groups, both training modalities elicited similar group*time interactions (P > 0.05) while experiencing benefits for glycated hemoglobin (HbA1c; P = 0.01), subcutaneous adiposity (P < 0.001), and heart rate variability (P = 0.02) during the 12-week intervention. Adiposity (P < 0.001) and aerobic capacity (P < 0.001) were significantly maintained in both groups at the 6-month follow-up. In addition, during the intervention, participants in both MICT+RT and HIIT+RT experienced favorable reductions in their medication usage. The study reported the inter-individual variability of change within both groups, the exaggerated acute physiological responses (using exercise termination indicators) that occurred during the interventions as well as the incidence of precautionary respite afforded in such a study sample. To reduce hyperglycaemia, and prevent further deterioration of cardiometabolic risk and microvascular complication markers (in both the short- and medium-term), future strategies that integrate the adoption and maintenance of physical activity as a cornerstone in the treatment of T2M for men should (cognisant of appropriate supervision) include either structured MICT+RT, or HIIT+RT.Clinical Trials Registration Number: ACTRN12617000582358 http://www.anzctr.org.au/default.aspx

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Section: Discussionsupporting

confidence: 81%

Section: Discussionsupporting

confidence: 65%

Section: Discussionsupporting

confidence: 60%

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High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes

et al. 2018

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“…(TSAI et al, 2016;HORNBUCKLE et al, 2017;STOA et al, 2017;THUM et al, 2017). Esses por sua vez, podem interferir indiretamente na qualidade de vida, disfunção sexual, distúrbios relacionados à imagem corporal e flutuações do humor (HAHN et al, 2005;JONES et al 2011;BAZARGANIPOUR et al, 2013;BENETTI-PINTO et al, 2015;DASHTI et al, 2016;SHISHEHGAR et al, 2016;PANICO et al, 2017).…”

Section: Introductionunclassified

“…Outros autores têm relatado que o treinamento intermitente promove maior adesão e é mais efetivo para a melhora da capacidade aeróbia, adaptações hemodinâmicas e redução de fatores de riscos cardiovasculares e de índices antropométricos (TSAI et al, 2016;HORNBUCKLE et al, 2017;STOA et al, 2017;THUM et al, 2017). Por outro lado, outros autores descreveram que o treinamento aeróbio contínuo foi melhor que o treinamento aeróbio intermitente quanto à melhoria da distribuição de gordura corporal e no estímulo da absorção de glicose pela insulina (KEATING et al, 2014;MOTIANI et al, 2017 …”

Section: Introductionunclassified

Efeitos do treinamento físico aeróbio sobre a função sexual em mulheres com síndrome dos ovários policísticos: ensaio clínico controlado

Lopes¹

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DEDICATÓRIA"Dedico este trabalho primeiramente а Deus, por ser essencial em minha vida, autor de meu destino, meu guia, socorro presente na hora da angústia." "Ao meu marido Victor pelo incentivo, apoio e motivação, que fez eu acreditar e confiar em mim mesma, sempre me apoiando e sendo companheiro nos momentos difíceis." "Aos meus pais, irmãos que, mesmo com a distância, cоm muito carinho, sempre me apoiaram nas decisões." "Às pessoas com quem convivi em Ribeirão Preto ao longo desses anos. А experiência de uma produção compartilhada na comunhão com amigos foi uma experiência única. AGRADECIMENTOSMuitas pessoas já se faziam presentes me apoiando e fortalecendo o meu caminho e várias outras foram surgindo nesta jornada.Agradeço primeiramente à Deus, aos meus pais e ao meu marido agradeço a vocês pela compreensão, confiança, incentivo, pois são meus maiores apoiadores e de fato conhecem todo o caminho trilhado até aqui e me deram forças para persistir e nunca desistir.Agradeço também a minha orientadora. Dra Lúcia Alves da Silva Lara por me proporcionar mais um passo dado à frente em minha vida profissional. Obrigado também pelas horas dispendidas com o objetivo de melhorar o nosso trabalho.Agradeço também a Profa. Dra. Rosana Maria dos Reis pela oportunidade, confiança e pelo acolhimento em seu grupo de pesquisa proporcionando uma experiência única.A todos os colegas que participaram de toda coleta de dados, seja no Laboratório CEFER ou no multicêntrico ou no Departamento de Ginecologia e Obstetrícia (Ana Paula, Rafael, Stella, Tábata, Eduardo, Gislaine, Cristiana, Daiana, Aline, Viviane, Océlia, Cidinha, Dr. Anderson, Suelen e Suleimy) que estiveram presentes nesses últimos dois anos de caminhada, uns mais e outros menos, mas que foram muito importantes, seja em uma simples conversa ou ajudando no projeto.A todos os meus amigos, parentes, a todas as voluntárias, à CNPQ e FAPESP e todas as outras pessoas que não estão nominalmente neste texto, mas que sabem que participaram desta vitória e agradeço imensamente por isso.

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Continuous and interval training attenuate encephalomyelitis by separate immunomodulatory mechanisms

Goldberg

Fainstein

Zaychik

et al. 2020

Ann Clin Transl Neurol

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BackgroundStudies have reported beneficial effects of exercise training on autoimmunity, and specifically on multiple sclerosis (MS) and experimental autoimmune encephalomyelitis (EAE). However, it is unknown whether different training paradigms affect disease course via shared or separate mechanisms.ObjectiveTo compare the effects and mechanism of immune modulation of high intensity continuous training (HICT) versus high intensity interval training (HIIT) on systemic autoimmunity in EAE.MethodsWe used the proteolipid protein (PLP)‐induced transfer EAE model to examine training effects on the systemic autoimmune response. Healthy mice performed HICT or HIIT by running on a treadmill. Lymph‐node (LN)‐T cells from PLP‐immunized trained‐ versus sedentary donor mice were transferred to naïve recipients and EAE clinical and pathological severity were assessed. LN cells derived from donor trained and sedentary PLP‐immunized mice were analyzed in vitro for T‐cell activation and proliferation, immune cell profiling, and cytokine mRNA levels and cytokine secretion measurements.ResultsBoth HICT and HIIT attenuated the encephalitogenicity of PLP‐reactive T cells, as indicated by reduced EAE clinical severity and inflammation and tissue pathology in the central nervous system, following their transfer into recipient mice. HICT caused a marked inhibition of PLP‐induced T‐cell proliferation without affecting the T‐cell profile. In contrast, HIIT did not alter T‐cell proliferation, but rather inhibited polarization of T cells into T‐helper 1 and T‐helper 17 autoreactive populations.InterpretationHICT and HIIT attenuate systemic autoimmunity and T cell encephalitogenicity by distinct immunomodulatory mechanisms.

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High-intensity aerobic interval training improves aerobic fitness and HbA1c among persons diagnosed with type 2 diabetes

Abstract: HAIT is an effective exercise strategy to improve aerobic fitness and reduce risk factors associated with T2D.

Cited by 81 publications

References 62 publications

High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes

High-Intensity Interval Training Is Equivalent to Moderate-Intensity Continuous Training for Short- and Medium-Term Outcomes of Glucose Control, Cardiometabolic Risk, and Microvascular Complication Markers in Men With Type 2 Diabetes

Efeitos do treinamento físico aeróbio sobre a função sexual em mulheres com síndrome dos ovários policísticos: ensaio clínico controlado

Continuous and interval training attenuate encephalomyelitis by separate immunomodulatory mechanisms

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