Tolerance development in food protein-induced allergic proctocolitis: Single centre experience

Erdem, Semiha Bahçeci; Nacaroğlu, Hikmet Tekin; Karaman, Sait; Erdur, Cahit Barış; Karkıner, C.U.; Can, Demet

doi:10.1016/j.aller.2016.10.005

Cited by 30 publications

(28 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Food protein–induced allergic proctocolitis is a non‐IgE‐mediated condition that usually occurs within the first 3 months of life . It represents the benign end of the spectrum of non‐IgE‐mediated allergy, and in about 60% of cases, it occurs in breastfed babies whose mothers are ingesting cow's milk or soya protein .…”

Section: The Natural Course Of Non‐ige‐mediated Gastrointestinal Allementioning

confidence: 99%

“…Eosinophils may be directly responsible for tissue injury in food protein–induced allergic proctocolitis because they can bind IgA, which are normally present in breastmilk, and undergo degranulation . The majority of infants with food protein–induced allergic proctocolitis become tolerant to offending food allergens by around 14 months of age (±11 months) according to several publications …”

Section: The Natural Course Of Non‐ige‐mediated Gastrointestinal Allementioning

confidence: 99%

“…Food protein-induced allergic proctocolitis is a non-IgE-mediated condition that usually occurs within the first 3 months of life. 14,35,36 It represents the benign end of the spectrum of non-IgE-mediated allergy, and in about 60% of cases, it occurs in breastfed babies whose mothers are ingesting cow's milk or soya protein. 37,38 It has been suggested that both intestinal immaturity and marked eosinophilic infiltration, which may significantly alter tight junctions, may lead to increased intestinal permeability to food proteins in infants leading to proctocolitis.…”

Section: Food Protein-induced Allergic Proctocolitismentioning

confidence: 99%

“…37 The majority of infants with food proteininduced allergic proctocolitis become tolerant to offending food allergens by around 14 months of age (±11 months) according to several publications. 36,39…”

Section: Food Protein-induced Allergic Proctocolitismentioning

confidence: 99%

See 3 more Smart Citations

Non‐IgE‐mediated gastrointestinal allergies—Do they have a place in a new model of the Allergic March

Fox

Lozinsky

Michaelis

et al. 2019

Pediatric Allergy Immunology

View full text Add to dashboard Cite

The rise in food allergy has been described as the “second wave” of the allergy epidemic, with some developed countries reporting a prevalence of 10% of challenge‐proven food allergies. Recognition of the Allergic March has played a crucial role in identifying causality in allergic conditions, linking atopic dermatitis to food allergy and food allergy to other atopic disorders, thereby highlighting opportunities in prevention and the importance of early intervention. This publication will establish the value of weaving the less well‐understood, non‐IgE‐mediated food allergy into the Allergic March and mapping its progression through childhood and its associated co‐morbidities. The proposed non‐IgE‐mediated Allergic March highlights the concomitant presentation of gastrointestinal symptoms and atopic dermatitis as early presenting symptoms in confirmed non‐IgE‐mediated allergies and the later development of atopic co‐morbidities, including asthma and allergic rhinitis, similar to the IgE‐mediated Allergic March. This publication highlights recent observations of a link between non‐IgE‐mediated food allergy in early childhood and functional gastrointestinal disorders in later life and also the reported occurrence of extra‐intestinal manifestations at later ages. Although significant limitations exist in regard to the proposed evolution of the Allergic March model, the authors hope that this publication will influence the management of non‐IgE‐mediated gastrointestinal allergies and inform future research and interventions.

show abstract

Section: The Natural Course Of Non‐ige‐mediated Gastrointestinal Allementioning

confidence: 99%

Section: The Natural Course Of Non‐ige‐mediated Gastrointestinal Allementioning

confidence: 99%

Section: Food Protein-induced Allergic Proctocolitismentioning

confidence: 99%

Section: Food Protein-induced Allergic Proctocolitismentioning

confidence: 99%

See 2 more Smart Citations

Non‐IgE‐mediated gastrointestinal allergies—Do they have a place in a new model of the Allergic March

Fox

Lozinsky

Michaelis

et al. 2019

Pediatric Allergy Immunology

View full text Add to dashboard Cite

show abstract

“…As mentioned earlier, AP is characterized by blood-streaked and mucousy normal to moderately loose stools in otherwise healthy, thriving infants. These characteristic symptoms can present within days of birth to 6 months of age, although older presentations have been noted [ 2 , 3 , 16 , 17 ]. Also, there have been cases of the development of AP in children aged 2–14 years [ 18 ].…”

Section: Apmentioning

confidence: 99%

Non-IgE-mediated food hypersensitivity

Connors

O’Keefe

Rosenfield

et al. 2018

Allergy Asthma Clin Immunol

View full text Add to dashboard Cite

Non-immunoglobulin E (IgE)-mediated food hypersensitivity includes a spectrum of disorders that predominantly affect the gastrointestinal tract. This review will focus on the following more common non-IgE-mediated food hypersensitivity syndromes: food protein-induced enterocolitis syndrome (FPIES), allergic proctocolitis (AP), food protein-induced enteropathy (FPE) and celiac disease. FPIES, AP and FPE typically present in infancy and are most commonly triggered by cow’s milk protein or soy. The usual presenting features are profuse emesis and dehydration in FPIES; blood-streaked and mucousy stools in AP; and protracted diarrhea with malabsorption in FPE. Since there are no confirmatory noninvasive diagnostic tests for most of these disorders, the diagnosis is based on a convincing history and resolution of symptoms with food avoidance. The mainstay of management for FPIES, AP and FPE is avoidance of the suspected inciting food, with periodic oral food challenges to assess for resolution, which generally occurs in the first few years of life. Celiac disease is an immune-mediated injury caused by the ingestion of gluten that leads to villous atrophy in the small intestine in genetically susceptible individuals. Serologic tests and small intestinal biopsy are required to confirm the diagnosis of celiac disease, and management requires life-long adherence to a strict gluten-free diet.

show abstract

Non-IgE Food Immunological Diseases

2019

View full text Add to dashboard Cite

Tolerance development in food protein-induced allergic proctocolitis: Single centre experience

Abstract: Smaller onset age and onset of symptoms during breastfeeding were found associated with early tolerance development. In the majority of the patients, FPIAP resolves before the age of one year, however in some of the patients this duration may be much longer.

Cited by 30 publications

References 26 publications

Non‐IgE‐mediated gastrointestinal allergies—Do they have a place in a new model of the Allergic March

Non‐IgE‐mediated gastrointestinal allergies—Do they have a place in a new model of the Allergic March

Non-IgE-mediated food hypersensitivity

Non-IgE Food Immunological Diseases

Contact Info

Product

Resources

About