Validity of height loss as a predictor for prevalent vertebral fractures, low bone mineral density, and vitamin D deficiency

Mikula, Anthony L.; Hetzel, Scott; Binkley, Neil; Anderson, Paul A.

doi:10.1007/s00198-017-3937-z

Cited by 26 publications

(37 citation statements)

References 24 publications

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“…Height loss is an age-related physical change that occurs in all individuals over 50 years and that elderly people are aware of [10], and is correlated with osteoporosis [11,12], vertebral fracture [13][14][15][16], and mortality [17]. Decreased QOL is also reportedly associated with height loss according to the EQ-5D scores [18].…”

Section: Introductionmentioning

confidence: 99%

Adult spinal deformity and its relationship with height loss: a 34-year longitudinal cohort study

Shimizu

Kobayashi

Chiba³

et al. 2020

BMC Musculoskelet Disord

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Background: Age-related height loss is a normal physical change that occurs in all individuals over 50 years of age. Although many epidemiological studies on height loss have been conducted worldwide, none have been longterm longitudinal epidemiological studies spanning over 30 years. This study was designed to investigate changes in adult spinal deformity and examine the relationship between adult spinal deformity and height loss. Methods: Fifty-three local healthy subjects (32 men, 21 women) from Furano, Hokkaido, Japan, volunteered for this longitudinal cohort study. Their heights were measured in 1983 and again in 2017. Spino-pelvic parameters were compared between measurements obtained in 1983 and 2017. Individuals with height loss were then divided into two groups, those with degenerative spondylosis and those with degenerative lumbar scoliosis, and different characteristics were compared between the two groups. Results: The mean age of the subjects was 44.4 (31-55) years at baseline and 78.6 (65-89) years at the final followup. The mean height was 157.4 cm at baseline and 153.6 cm at the final follow-up, with a mean height loss of 3.8 cm over 34.2 years. All parameters except for thoracic kyphosis were significantly different between measurements taken in 1983 and 2017 (p < 0.05). Height loss in both sexes was related to changes in pelvic parameters including pelvic incidence-lumbar lordosis (R = 0.460 p = 0.008 in men, R = 0.553 p = 0.012 in women), pelvic tilt (R = 0.374 p = 0.035 in men, R = 0.540 p = 0.014 in women), and sagittal vertical axis (R = 0.535 p = 0.002 in men, R = 0.527 p = 0.017 in women). Greater height loss was more commonly seen in women (p = 0.001) and in patients with degenerative lumbar scoliosis (p = 0.02). Conclusions: This longitudinal study revealed that height loss is more commonly observed in women and is associated with adult spinal deformity and degenerative lumbar scoliosis. Height loss is a normal physical change with aging, but excessive height loss is due to spinal kyphosis and scoliosis leading to spinal malalignment. Our findings suggest that height loss might be an early physical symptom for spinal malalignment.

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Section: Introductionmentioning

confidence: 99%

Adult spinal deformity and its relationship with height loss: a 34-year longitudinal cohort study

Shimizu

Kobayashi

Chiba³

et al. 2020

BMC Musculoskelet Disord

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“…Furthermore, the proportion of individuals with GNRI <92 was significantly higher in the fracture group than in the non‐fracture group. Also, it has been reported that malnutrition increases the risk of fracture . As is evident from the above, increased anticholinergic load reduces the amount of salivary secretion, causing mouth dryness, and thereby resulting in reduced food intake and drug‐induced malnutrition, which are believed to be associated with the onset of hip fracture.…”

Section: Discussionmentioning

confidence: 98%

“…Also, it has been reported that malnutrition increases the risk of fracture. 23 As is evident from the above, increased anticholinergic load reduces the amount of salivary secretion, causing mouth dryness, and thereby resulting in reduced food intake and drug-induced malnutrition, which are believed to be associated with the onset of hip fracture. Therefore, in patients who are administered anticholinergic drugs, the options of dose reduction or termination should be examined.…”

Section: Discussionmentioning

confidence: 99%

Anticholinergic drugs use and risk of hip fracture in geriatric patients

Kose

Hirai

Seki

2018

Geriatrics Gerontology Int

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“…Previous research found that vertebral height loss was an important sign of LVF. Mikula et al 36 reported that gradual height loss is a useful measurement tool to identify patients with LVF. Other prospective research, conducted by Moayyeri et al, 37 found that height loss was an important independent risk factor of future LVF at any site (.2 cm over a period of 4 years).…”

Section: Discussionmentioning

confidence: 99%

<p>Dorsal and ventral thoracic 12 vertebra body height is associated with incident lumbar vertebral fracture in postmenopausal osteoporotic women</p>

Bang

Lee

Kang

et al. 2019

CIA

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Purpose: We measured dorsal and ventral thoracic 12 vertebral (T12V) body heights as a way to predict lumbar vertebral fracture (LVF) in postmenopausal women. MRI of dorsal and ventral T12V body heights has not yet been used to investigate their association with LVF. We hypothesized that the dorsal and ventral T12V body height are important morphologic parameters in the prediction of LVF. Patients and methods: In total, 80 osteoporotic patients with LVF (LVF group) and 80 osteoporotic patients without LVF (control group) were examined by MRI at the lumbothoracic level. Sagittal T2-weighted MRI images in the T12 level were obtained from all subjects. We analyzed both the dorsal and ventral T12V body height. The difference in dorsal and ventral body heights of the control and LVF patients was calculated at the T12V level. Results: The average dorsal T12V body height was 21.25±1.64 mm in the control group and 20.11±1.49 mm in the LVF group. The average ventral T12V body heights were 19.51±1.54 mm and 17.62±1.95 mm, respectively. The LVF group had significantly lower dorsal and ventral T12V body heights (both P,0.001). ROC curve analysis showed the best cutoff value for dorsal T12V body height value of 20.74 mm, with 62.5% sensitivity and 60.0% specificity. The best cutoff point of ventral T12V body height was 18.76 mm, with 68.8% sensitivity and 67.5% specificity. Conclusion: This study confirmed the association between dorsal and ventral T12V body height and occurrence of LVF in postmenopausal women with osteoporosis. Dorsal and ventral T12V body height were both significantly associated with LVF, with ventral T12V body height being a more sensitive measurement parameter. Thus, to predict risk of LVF in patients, the treating physician should carefully inspect the ventral T12V body height.

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Validity of height loss as a predictor for prevalent vertebral fractures, low bone mineral density, and vitamin D deficiency

Cited by 26 publications

References 24 publications

Adult spinal deformity and its relationship with height loss: a 34-year longitudinal cohort study

Adult spinal deformity and its relationship with height loss: a 34-year longitudinal cohort study

Anticholinergic drugs use and risk of hip fracture in geriatric patients

<p>Dorsal and ventral thoracic 12 vertebra body height is associated with incident lumbar vertebral fracture in postmenopausal osteoporotic women</p>

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