Effects of platelet-rich fibrin on healing of intra-bony defects treated with anorganic bovine bone mineral

Abstract

Anorganic bovine bone mineral (ABBM) is extensively used in the treatment of intra-bony defects. Platelet-rich fibrin (PRF) is a new-generation platelet concentrate with a simplified technique. Although certain studies have reported the use of PRF in the treatment of intra-bony defects, to date, none of them have evaluated its additive effects with ABBM. Therefore, a randomised, split-mouth clinical trial was conducted to compare healing of intra-bony defects treated with an ABBM-PRF combination with healing of those treated with ABBM alone. By using a split-mouth design, 15 paired intra-bony defects were randomly treated with either ABBM alone (control group) or ABBM-PRF combination (test group). Following clinical parameters and radiographical measurements were recorded at baseline and 6 months after treatment: plaque index (PI), gingival index (GI), probing depth (PD), gingival recession (GR), clinical attachment level (CAL), vertical bone loss, depth of defect and defect angle. Preoperative clinical and radiographical measurements were similar for the test and control groups. Statistically significant reductions in GI, PD, CAL, vertical bone loss, depth of intra-bony defect and widening of defect angle were detected after treatment in both groups. With respect to inter-group analysis, gain in CAL was significantly greater in the test group than in the control group, whereas no inter-group differences were observed in any other parameter. The results of this study indicate that both therapies are effective in the treatment of intra-bony defects.

The 3 R’s for Platelet-Rich Fibrin: A “Super” Tri-Dimensional Biomaterial for Contemporary Naturally-Guided Oro-Maxillo-Facial Soft and Hard Tissue Repair, Reconstruction and Regeneration

“…Seven RCTs addressing the prospective application of PRFs periodontal therapy IBD have been found. Articles that have been found allowed for the following comparisons: (a) PRF/open flap surgery versus open flap surgery [9,10,11]; (b) PRF/Bio-Oss ® constructs (Bio-Oss ® , Geistlich Pharma North America, Inc., Princeton, NJ, USA) versus PRF [12] and (c) PRF/DFDBA constructs versus DFDBA (demineralized freeze-dried bone allograft) [13] (d) PRF/inorganic bovine bone mineral (ABBM) versus ABBM alone [14] and (e) resorbable collagen membrane + PRF versus guidance tissue regeneration [15]. All of the patients who were included in those studies were periodontally stable and systemically healthy individuals who presented: a similar bilateral IBD of at least 5-mm probing depth located in vital asymptomatic teeth with no furcation involvement.…”

Platelet‐rich fibrin and collagen membrane in the preservation of the alveolar bone: Feasibility of the elemental inorganic composition and scanning electron microscopy analysis

“…The increasing interest in understanding the effects of platelet concentrate application on bone tissue is reflected in the number of recent studies that have examined this topic (Al‐Hamed et al, ; Canellas et al, ; Cortese et al, ; Isobe et al, ; Panda et al, ). Although there have been studies that have used models of bone lesions in animals to clarify the effects of these platelet concentrates at different levels (Acar et al, ; Bölükbaşı, Yeniyolm, Tekkesinm, & Altunatmaz, ; Du et al, ; Ocak et al, ), there are also clinical studies that focus on radiological (Cortese et al, ; Park et al, ) and tomographic analyses (Lim et al, ; Montanari, Callea, Yavuz, & Maglione, ; Öncü & Kaymaz, ) and its use in clinical settings (Barone et al, ; Panda et al, ; Sezgin, Uraz, Taner, & Çulhaoğlu, ), all of which seek to evaluate the effects of this therapy. Our clinical case study differs from these investigations as it evaluates the ultrastructure of neoformed bone tissue and the quantity of inorganic elements of HA present.…”

“…The qualitative data and the meta‐analysis of systematic review did not reveal a significant improvement in the recovery of postextracting alveoli with PRF compared to normal recovery (Al‐Hamed et al, ). PRF was unable to enhance some clinical parameter values such as improvements to the gingival index, probing depth, clinical attachment level, vertical bone loss, depth of intrabony defect, and angular defect widening in inorganic bovine bone mineral (Sezgin et al, ). PRF membranes have shown slightly inferior biocompatibility compared to collagen membranes in the proliferation of periosteal cells (Gassling et al, ).…”

Detection of Bone Mineral Density Changes by Subtraction of Cone-Beam Computed Tomography Images: A Pilot Study

“…This process consists in the removal of mineralized bone by osteoclasts followed by formation of new bone matrix through osteoblasts that subsequently become mineralized. [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16] Subtle mineral bone changes are difficult to observe by visual analysis, thus changes in bone are usually monitored using sequential images taken by conventional radiograph methods or computerized tomography at different follow-up periods. Other alternative method to monitor bone healing is the utilization of digital subtraction radiography (DSR) associated to computer-assisted image processing.…”

“…DSR has been used both in vitroand in clinical studies as a sensitive tool to monitor minor bone changes, including mineral loss and gain. [9][10][11][12][13][14][15][16][17][18] The DSR method is based on the digital alignment and superimposition of two radiographs of the same region obtained at different time. 19 A subtracted image is produced using a specific software system algorithm that converts the two radiographic images into a homogeneous grey background of 128 pixels.…”