Orbital lymphomas missed by first biopsies of orbital masses

Eenhorst, Christine A.E.; Laban, Kamil G.; Leguit, Roos J.; Kalmann, Rachel

doi:10.1111/aos.13350

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…2 Most cases of orbital lymphoma are unilateral and derive from B lymphocyte origins or mucosa-associated lymphoid tissue origins. [3][4][5] Mantle cell lymphoma is relatively rare, representing only 2% to 7% of all orbital lymphoma cases. 6 It may present as a secondary lymphoma of the orbit or eyelid, most often in older men.…”

Section: Discussionmentioning

confidence: 99%

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An Orbital Lesion Diagnosed on Routine Fundus Examination

2019

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Section: Discussionmentioning

confidence: 99%

“…Orbital lymphoma is the most common orbital neoplasm in adults . Most cases of orbital lymphoma are unilateral and derive from B lymphocyte origins or mucosa-associated lymphoid tissue origins . Mantle cell lymphoma is relatively rare, representing only 2% to 7% of all orbital lymphoma cases .…”

Section: Discussionmentioning

confidence: 99%

An Orbital Lesion Diagnosed on Routine Fundus Examination

2019

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“…Prompt diagnosis is critical to disease management and prognosis. NHOL can present with similar symptoms as orbital inflammatory disease, such as idiopathic orbital inflammation (IOI), the most common non‐thyroid associated orbital inflammatory disorder . Differentiating between the two can be difficult, particularly when histopathology is inconclusive or when an incisional biopsy is difficult to obtain due to deep orbital localization .…”

Section: Introductionmentioning

confidence: 99%

cDC2 and plasmacytoid dendritic cells diminish from tissues of patients with non‐Hodgkin orbital lymphoma and idiopathic orbital inflammation

et al. 2020

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Non‐Hodgkin orbital lymphoma (NHOL) and idiopathic orbital inflammation (IOI) are common orbital conditions with largely unknown pathophysiology. To investigate the immune cell composition of these diseases, we performed standardized 29 parameter flow cytometry phenotyping in peripheral blood mononuclear cells of 18 NHOL patients, 21 IOI patients, and 41 unaffected controls. Automatic gating by FlowSOM revealed decreased abundance of meta‐clusters containing dendritic cells in patients, which we confirmed by manual gating. A decreased percentage of (HLA‐DR+CD303+CD123+) plasmacytoid dendritic cells (pDC) in the circulation of IOI patients and decreased (HLA‐DR+CD11c+CD1c+) conventional dendritic cells (cDC) type‐2 for IOI patients were replicated in an independent cohort of patients and controls. Meta‐analysis of both cohorts demonstrated that pDCs are also decreased in blood of NHOL patients and highlighted that the decrease in blood cDC type‐2 was specific for IOI patients compared to NHOL or controls. Deconvolution‐based estimation of immune cells in transcriptomic data of 48 orbital biopsies revealed a decrease in the abundance of pDC and cDC populations within the orbital microenvironment of IOI patients. Collectively, these data suggest a previously underappreciated role for dendritic cells in orbital disorders.

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