Effects of compensatory cognitive training intervention for breast cancer patients undergoing chemotherapy: a pilot study

Park, Jin Hee; Jung, Yongsik; Kim, Ku Sang; Bae, Sun Hyoung

doi:10.1007/s00520-017-3589-8

Cited by 39 publications

(41 citation statements)

References 34 publications

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“…A study in early-stage breast cancer survivors with cognitive complaints ( N = 82; mean age = 56.5 ± 8.5; time post-treatment = 5.5 ± 4.2 years) reported improvements in objectively measured memory and speed of processing, as well as perceived cognitive functioning immediately after in-person cognitive training delivered in a group setting and at 2-months follow-up, compared to waitlist controls (all p < 0.04) ( Von Ah et al, 2012 ). Several other studies in breast cancer survivors showed similar results, some of them with home-based training intervention ( Kesler et al, 2013a ; Ercoli et al, 2015 ; Ferguson et al, 2016 ; Park et al, 2017 ; Meneses et al, 2018 ). A study evaluating web-based cognitive training in breast cancer survivors with CRCI ( N = 94; mean age = 54.98 ± 8.51) did not result in improvement of perceived cognitive functioning, but improved performance was observed on verbal learning and working memory tests at 5-months follow-up, compared to waitlist controls ( p = 0.040–0.043) ( Damholdt et al, 2016 ).…”

Section: Treatment Of Cancer-related Cognitive Impairmentsupporting

confidence: 57%

Long-Term Cognitive Dysfunction in Cancer Survivors

Országhová

Mego

Chovanec

2021

Front. Mol. Biosci.

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Cancer-related cognitive impairment (CRCI) is a frequent side effect experienced by an increasing number of cancer survivors with a significant impact on their quality of life. Different definitions and means of evaluation have been used in available literature; hence the exact incidence of CRCI remains unknown. CRCI can be described as cognitive symptoms reported by cancer patients in self-reported questionnaires or as cognitive changes evaluated by formal neuropsychological tests. Nevertheless, association between cognitive symptoms and objectively assessed cognitive changes is relatively weak or absent. Studies have focused especially on breast cancer patients, but CRCI has been reported in multiple types of cancer, including colorectal, lung, ovarian, prostate, testicular cancer and hematological malignancies. While CRCI has been associated with various treatment modalities, including radiotherapy, chemotherapy, hormone therapy and novel systemic therapies, it has been also detected prior to cancer treatment. Therefore, the effects of cancer itself with or without the psychological distress may be involved in the pathogenesis of CRCI as a result of altered coping mechanisms after cancer diagnosis. The development of CRCI is probably multifactorial and the exact mechanisms are currently not completely understood. Possible risk factors include administered treatment, genetic predisposition, age and psychological factors such as anxiety, depression or fatigue. Multiple mechanisms are suggested to be responsible for CRCI, including direct neurotoxic injury of systemic treatment and radiation while other indirect contributing mechanisms are hypothesized. Chronic neuroinflammation mediated by active innate immune system, DNA-damage or endothelial dysfunction is hypothesized to be a central mechanism of CRCI pathogenesis. There is increasing evidence of potential plasma (e.g., damage associated molecular patterns, inflammatory components, circulating microRNAs, exosomes, short-chain fatty acids, and others), cerebrospinal fluid and radiological biomarkers of cognitive dysfunction in cancer patients. Discovery of biomarkers of cognitive impairment is crucial for early identification of cancer patients at increased risk for the development of CRCI or development of treatment strategies to lower the burden of CRCI on long-term quality of life. This review summarizes current literature on CRCI with a focus on long-term effects of different cancer treatments, possible risk factors, mechanisms and promising biomarkers.

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Section: Treatment Of Cancer-related Cognitive Impairmentsupporting

confidence: 57%

Long-Term Cognitive Dysfunction in Cancer Survivors

Országhová

Mego

Chovanec

2021

Front. Mol. Biosci.

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“…Several study designs have focused on cognitive training, cognitive behavioral training or a combination of both. The results for neuropsychological performance are mixed but most of these trials demonstrated a reduced cognitive impairment after these interventions [ 9 , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] ]. In a systematic review assessing 19 studies on cognitive rehabilitation for CRCI including 1124 patients, Fernandes et al.…”

Section: Discussionmentioning

confidence: 99%

A video-game based cognitive training for breast cancer survivors with cognitive impairment: A prospective randomized pilot trial

et al. 2020

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Introduction We investigated whether a web-based cognitive training video game is an effective approach to improve cognitive decline in combination with our standard of care for rehabilitation of breast cancer (BC) patients. Materials and methods Self-selected BC patients between 18 and 71 years old complaining of disturbing cognitive impairment were studied. The patients received access to a web-based internet video game and online cognitive assessments (Aquasnap, Cambridge, MyCQ™). The early intervention group (n = 23) had a training program of 6 months of at least three times a week for a minimum of 60 min of game playing per week at home in addition to standard of care rehabilitation. The delayed intervention (n = 23) received standard of care for three months, followed by three months of similar MyCQ training. Outcome measures were the MyCQ (sub)scores and Activity of Daily Life (ADL), mood, subjective cognition and functional cognitive status measured by classic neuropsychological tests. Results At baseline the means for CFQ (a measure of self-reported cognitive failure), anxiety, PSQI and self-reflectiveness were beyond normal range in both groups. CFQ improved significantly better in the intervention group (p = 0.029). Combining the evolution over time in the entire population a significant improvement was seen for overall MyCQ score, level of fear, physical and emotional role limitation, and health change (all p < 0.05), but self-reflectivess deteriorated (p < 0.05)). Significant differences in the various MyCQ subtests over time were: improved speed in choice reaction time, visual memory recognition, N back 1 and 2, coding, trail making test B, improved accuracy of N back 1 and 2 (all p < 0.05). Conclusion A program of cognitive training improves cognitive functioning over time. “Aquasnap” has a beneficial effect on the perception of subjective cognitive functioning (CFQ) but the exact role of video gaming in this process remains uncertain.

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“…Pharmacological intervention for fatigue and cognitive impairment after cancer treatment has been tested in small studies, mainly with central nervous system stimulants used for attention disorders, such as Modafinil and Methylphenidate. Modafinil has been shown to enhance some memory and attention skills after adjuvant treatment with chemotherapy in breast cancer survivors [39]. Methylphenidate shows no improvement in quality of life or fatigue.…”

confidence: 99%

Experience of Developing a Cognitive Exercise Program in Patients Screened for Breast Cancer - A Pilot Study

Schedin

Johnsson

Hedayati

2020

COJNH

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Introduction: The pathophysiology for cognitive impairment is observed both in healthy women having false-positive mammography screening results and as a side-effect of breast cancer treatment. This randomized controlled pilot trial, a sub-study of Onk-kong trial aimed to compare the feasibility and acceptability of CRT versus standard of care on patients with an objective cognitive impairment in association with false-positive screening results as well as breast cancer treatment. Method: Women with false-positive screening results or breast cancer completed the Headminder Web-based neuropsychological battery Cognitive Stability Index for response speed, processing speed, memory, and attention before diagnosis, 9 months after diagnosis (T1), and after another 3 months of follow-up (T2). A total of 31 women with an objective cognitive impairment at T1 were prospectively enrolled and randomized between training programs and expectancy. A modified psychological training program developed for schizophrenic patients, Cognitive Remediation Therapy was used and tested, by trained nurses. Result: In total 14 women were randomized to Cognitive Remediation Therapy and 17 to expectancy. Of the randomized women, 12 fulfilled the criteria for inclusion in this study. Of these 12 women, 6 attended and fulfilled Cognitive Remediation Therapy. Five declined participation in the program, because of not having time, one couldn’t start due to lack of available trainer. At T2 the results showed no improvement in any group. The dependence of the clinical setting caused problem. Conclusion: Our study design did not enable us to demonstrate the feasibility and acceptability of the modified CRT-program among women with a breast cancer diagnosis as well as false-positive screening results or breast cancer. The study has identified several logistical issues. Changes need to be made in the conduct of the CRT to be useful also for breast cancer patients.

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Effects of compensatory cognitive training intervention for breast cancer patients undergoing chemotherapy: a pilot study

Abstract: The 12-week compensatory cognitive training significantly improved the objective and subjective cognitive functioning of breast cancer patients. Because this was a pilot study, further research using a larger sample and longer follow-up durations is necessary.

Cited by 39 publications

References 34 publications

Long-Term Cognitive Dysfunction in Cancer Survivors

Long-Term Cognitive Dysfunction in Cancer Survivors

A video-game based cognitive training for breast cancer survivors with cognitive impairment: A prospective randomized pilot trial

Experience of Developing a Cognitive Exercise Program in Patients Screened for Breast Cancer - A Pilot Study

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