Immunization and treatment updates: 2016‐2017 influenza season

Maurice, Annabelle de St; Halasa, Natasha

doi:10.1111/petr.12884

Pediatric Transplantation

2017

DOI: 10.1111/petr.12884

|View full text |Cite

Immunization and treatment updates: 2016‐2017 influenza season

Annabelle de St Maurice

Natasha Halasa

Abstract: Influenza-associated infections cause significant morbidity and mortality worldwide, particularly among immunocompromised patients. Immunization is the primary mode of prevention of disease; however, efficacy in immunocompromised patients may be limited. Antiviral medications are important for treatment and prophylaxis of affected individuals. This article reviews treatment and prevention recommendations for the 2016-2017 influenza season in the Northern Hemisphere and Southern Hemisphere.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2017

2019

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

(1 citation statement)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this issue of the Journal, de St. Maurice and Halasa provide a useful update on the prevention and treatment of influenza illness in pediatric transplant patients for the 2016‐2017 influenza season . Access to relatively frequent updates on recommendations for the prevention and treatment of Influenza in general, and in both adult and pediatric organ recipients in particular, is of critical importance as the influenza virus's ability to undergo antigenic drift and shift from one season to the next implies that the disease may differ from year to year, as can the appropriate vaccine strategy and treatment.…”

mentioning

confidence: 99%

Prevention and treatment of influenza illness: A seasonal challenge for transplant patients

Allen

Green

2017

Pediatric Transplantation

View full text Add to dashboard Cite

mentioning

confidence: 99%

Prevention and treatment of influenza illness: A seasonal challenge for transplant patients

Allen

Green

2017

Pediatric Transplantation

View full text Add to dashboard Cite

Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds

Kleinpeter

Jureka

Falahat

et al. 2018

Journal of Biological Chemistry

View full text Add to dashboard Cite

The influenza virus is a significant public health concern causing 250,000-500,000 deaths worldwide each year. Its ability to change quickly results in the potential for rapid generation of pandemic strains for which most individuals would have no antibody protection. This pandemic potential highlights the need for the continuous development of new drugs against influenza virus. As an essential component and well established virulence determinant, NS1 (nonstructural protein 1) of influenza virus is a highly prioritized target for the development of anti-influenza compounds. Here, we used NMR to determine that the NS1 effector domain (NS1) derived from the A/Brevig Mission/1/1918 (H1N1) strain of influenza (1918) binds to two previously described anti-influenza compounds A9 (JJ3297) and A22. We then used X-ray crystallography to determine the three-dimensional structure of the 1918 NS1 Furthermore, we mapped the A9/A22-binding site onto our 1918 NS1 structure and determined that A9 and A22 interact with the NS1 in the hydrophobic pocket known to facilitate binding to the 30-kDa subunit of the cleavage and polyadenylation specificity factor (CPSF30), suggesting that the two compounds likely attenuate influenza replication by inhibiting the NS1-CPSF30 interaction. Finally, our structure revealed that NS1 could dimerize via an interface that we termed the α-α dimer. Taken together, the findings presented here provide strong evidence for the mechanism of action of two anti-influenza compounds that target NS1 and contribute significant structural insights into NS1 that we hope will promote and inform the development and optimization of influenza therapies based on A9/A22.

show abstract

Impact of Pharmacy-Initiated Interventions on Influenza Vaccination Rates in Pediatric Solid Organ Transplant Recipients

Gattis

Yıldırım

Shane

et al. 2018

Journal of the Pediatric Infectious Diseases Society

View full text Add to dashboard Cite

Background In solid organ transplant (SOT) recipients, influenza infection can lead to subsequent graft dysfunction and death. Vaccination is the most effective approach to preventing influenza infection; however, vaccination rates are low, and interventions to optimize vaccine coverage are needed. The purpose of this study was to evaluate if pharmacy-initiated screening and recommendations for influenza immunization improve the rate of vaccination in pediatric SOT recipients. Methods We performed a retrospective pre-post chart review of all kidney, liver, and heart transplant recipients followed by Children’s Healthcare of Atlanta/Emory University transplant services between September 1, 2011, and February 16, 2017. Influenza vaccination coverage and influenza rates before (2011–2013) and after (2014–2016) the implementation of pharmacy-driven vaccination in SOT recipients were assessed. Results A total of 822 patients were included; 101 (13%) of these patients were diagnosed with influenza, and 40 (5%) were hospitalized secondarily during the study period. Vaccination coverage increased over time (144 [36%] patients vaccinated in 2011 vs 430 [74%] in 2016; P < .001). Influenza diagnosis rates decreased between the 2 eras (P = .006). The median time in which 50% of the population was vaccinated decreased over time from 163 days in 2012 to 94 days in 2016 (P < .001). Conclusion Within the constraints of the pre-post study design, we observed a significant increase in influenza vaccination rates after implementation of a transplant pharmacy-initiated screening and vaccination program. The number of patients diagnosed with influenza and the time to vaccination decreased after our pharmacy intervention. All efforts should be made to increase compliance with influenza vaccination; pharmacy-initiated interventions can improve protection against influenza infection in pediatric SOT recipients.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Immunization and treatment updates: 2016‐2017 influenza season

Cited by 4 publications

References 21 publications

Prevention and treatment of influenza illness: A seasonal challenge for transplant patients

Prevention and treatment of influenza illness: A seasonal challenge for transplant patients

Structural analyses reveal the mechanism of inhibition of influenza virus NS1 by two antiviral compounds

Impact of Pharmacy-Initiated Interventions on Influenza Vaccination Rates in Pediatric Solid Organ Transplant Recipients

Contact Info

Product

Resources

About