Gold nanorods reflectance discriminate benign from malignant oral lesions

Hirshberg, Abraham; Allon, Irit; Novikov, Ilya; Ankri, Rinat; Ashkenazy, Ariel; Fixler, Dror

doi:10.1016/j.nano.2017.01.003

Cited by 24 publications

(25 citation statements)

References 28 publications

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“…Likewise, in the femoral artery of hyperlipidemic mice, more gold deposition was observed after 24 hours, compared to the normal femoral artery (Figure D,E). This discrepancy is because normal CT can detect only very high concentrations (<2.9 mg/mL; a minimum 5 mg of Au of IV dose required per mouse, where a mouse has approximately 1.7 mL of blood in total) of gold accumulation in body organs . Although we have injected 6 mg of GNRs per mouse to detect gold intensity, the amount of gold retained in AS plaques was not high enough to be detectable by normal CT. Only HR‐CT, which being a time consuming process (with 0.3° rotation interval for each scan) is impossible to apply for human full‐body scan, could detect gold in AS plaque.…”

Section: Resultsmentioning

confidence: 91%

Hyperlipidemic mice as a model for a real‐time in vivo detection of atherosclerosis by gold nanorods‐based diffusion reflection technique

Chakraborty

Ankri

Leshem-Lev

et al. 2018

Journal of Biophotonics

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Atherosclerosis (AS), the leading cause of morbidity and mortality in cardiovascular disease, needs an early detection for treatment and prevention of fatal events. Here, for the first time, we applied gold nanorods (GNRs)-assisted diffusion reflection (DR), a noninvasive technique for in vivo detection of AS in a high-fat-diet-induced c57bl mouse model, which resembles the manifestation of AS in humans. DR simply detects the change in light reflection profile of tissue due to the accumulation of GNRs in the AS plaques and enables clear detection of AS lesions in carotid and femoral arteries of these hyperlipidemic mice. After 24 hours post-GNRs injection, DR showed the highest efficiency of AS detection. Moreover, the sensitivity of the DR method is much higher than computed tomography (CT) and is comparable to ex vivo high-resolution CT. Our results strongly suggest that the DR method can detect early atherosclerotic lesions in a sensitive and specific manner.

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Section: Resultsmentioning

confidence: 91%

Hyperlipidemic mice as a model for a real‐time in vivo detection of atherosclerosis by gold nanorods‐based diffusion reflection technique

Chakraborty

Ankri

Leshem-Lev

et al. 2018

Journal of Biophotonics

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“…One tested method is diffuse reflection evaluation in the case of functionalized NPs. 64 This has been tested as an innovative system based on conjugating functionalized GNRs with EGFR as diagnostic tools, founded on the fact that EGFR is overexpressed in tumor tissue. This is a useful instrument for mapping tumor margins by quantification of anti-EGFR-GNRs.…”

Section: And 111mentioning

confidence: 99%

“…65 The physical properties of GNRs, like their reflectance, allow discrimination of normal tissue from tumors. 64 Another important feature of GNRs is the unique scattering and absorption capacity evaluated using SEM. 65 The technique needs to be standardized prior to its clinical application.…”

Section: And 111mentioning

confidence: 99%

“…91 In vitro studies using lipid-based nanostructures NP-delivery systems can be beneficial not only for OSCC chemoprevention and therapy but also for its early detection and staging. A dimethylbenzanthracene-induced hamster buccal pouch model of oral dysplasia and SCC revealed that 18 F-FDG had low sensitivity during early stages; meanwhile, 64 Cu liposomes accumulated in all OSCC stages, thus confirming their superior sensitivity. As a radiotracer, 64 Cu liposomes are able to augment HNSCC visualization and early detection.…”

mentioning

confidence: 91%

“…A dimethylbenzanthracene-induced hamster buccal pouch model of oral dysplasia and SCC revealed that 18 F-FDG had low sensitivity during early stages; meanwhile, 64 Cu liposomes accumulated in all OSCC stages, thus confirming their superior sensitivity. As a radiotracer, 64 Cu liposomes are able to augment HNSCC visualization and early detection. 67 Boron neutron-capture therapy is a dual cancer-therapy option that combines selective buildup of tumor-targeting compounds containing boron and neutron irradiation.…”

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confidence: 91%

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Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Irimie

Sonea²,

Jurj

et al. 2017

IJN

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Oral cancer is a prevalent cancer type on a global scale, whose traditional treatment strategies have several drawbacks that could in the near future be overcome through the development of novel therapeutic and prognostic strategies. Nanotechnology provides an alternative to traditional therapy that leads to enhanced efficiency and less toxicity. Various nanosystems have been developed for the treatment of oral cancer, including polymeric, metallic, and lipid-based formulations that incorporate chemotherapeutics, natural compounds, siRNA, or other molecules. This review summarizes the main benefits of using these nanosystems, in parallel with a particular focus on the issues encountered in medical practice. These novel strategies have provided encouraging results in both in vitro and in vivo studies, but few have entered clinical trials. The use of nanosystems in oral cancer has the potential of becoming a valid therapeutic option for patients suffering from this malignancy, considering that clinical trials have already been completed and others are currently being developed.

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Diffused reflectance measurements to detect tattoo ink location in skin using the crossover point

Rudraiah

Duadi

Fixler

2022

Journal of Biophotonics

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Tattoos are highly trendy in western culture, but many people regret their tattoos for many reasons. It is essential to be aware of the ink location in advance to reduce the long and short-term side effects. In this study, diffuse reflectance (DR) experiments were conducted on two-layer (2L) tissue-mimicking phantoms, where ink was sandwiched between the layers. An appreciable difference in the DR profile was found between the 2L phantom with and without the tattoo ink using the crossover point (Cp) method. Our technique was applied to ex vivo porcine skin. A point of intersection was found, between the skin and the tattooed skin. In the shorter wavelengths (500-600 nm), a distinguishable 2L behavior was found, and in longer wavelengths (600-850 nm), a single layer behavior was found between the tattooed skin before and after the intersection. In biological tissue, this Cp indeed finds the tattoo ink without harm to the surrounding skin.

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Gold nanorods reflectance discriminate benign from malignant oral lesions

Cited by 24 publications

References 28 publications

Hyperlipidemic mice as a model for a real‐time in vivo detection of atherosclerosis by gold nanorods‐based diffusion reflection technique

Hyperlipidemic mice as a model for a real‐time in vivo detection of atherosclerosis by gold nanorods‐based diffusion reflection technique

Future trends and emerging issues for nanodelivery systems in oral and oropharyngeal cancer

Diffused reflectance measurements to detect tattoo ink location in skin using the crossover point

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