Development of a model to predict the 10-year cumulative risk of second primary cancer among cancer survivors

Moitry, Marie; Velten, Michel; Trétarre, Brigitte; Bara, Simona; Daubisse‐Marliac, Laetitia; Lapôtre-Ledoux, Bénédicte; Troussard, Xavier; Molinié, F.; Ligier, Karine; Woronoff, Anne‐Sophie; Bouvier, Anne–Marie; Colonna, Marc; Klein, Delphine; Guizard, Anne‐Valérie; Jégu, Jérémie

doi:10.1016/j.canep.2017.01.001

Cited by 11 publications

(2 citation statements)

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“…The relative risk of SPT in cancer survivors is higher than the general population because of persistent exposure to behavioral risk factors, genetic susceptibility, long survival after the index cancer, and the effects of therapies made up for the primary cancer (Moitry et al., 2017; Preyer et al., 2017). Following the definition of the International Association of Cancer Registers (IARC), a primary cancer is one that originates in a primary site or tissue and it is not an extension, a recurrence or a metastasis of a previous neoplasm; the recognition of the existence of two (or more) primary cancers does not depend on time and the second primary can be synchronous (coexisting with the first) or metachronous (developed after >6 months) (2005).…”

Section: Discussionmentioning

confidence: 99%

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

et al. 2020

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Objective Head and neck cancer survivors have increased risk of developing second primary tumors compared to overall population. Because second primary represents a major cause of morbidity and mortality in this population, early detection is fundamental. Materials and Methods In this 10‐year single‐institution study, we investigated the following: incidence, clinical‐pathological risk factors, and survival of patients with second primary tumor. We included all patients with diagnosis of squamous cell carcinoma of the head and neck seen at the Modena University Hospital from 2008 to 2018. Results Among 1,177 patients included, 222 (18.9%) developed second primary tumor; its survival probability at 5 years was 40.6%. Alcohol consumption (p = .0055) and index cancer in oropharynx (p = .0029), supraglottic larynx (p = .0000), glottic larynx (p = .0222) were associated with higher risk of second primary. The most common second primary sites were head and neck district and lung (70, 31.5%, and 67, 30.2%, respectively). Head and neck district were more common in oral cavity (18, 43%) and oropharynx index cancer (20, 31%); lung second primary in hypopharynx (4, 40%), supraglottic larynx (17, 43%), and glottic larynx index cancer (23, 35%). Conclusion Head and neck cancer survivors developing a second primary tumor have dismal prognosis. Tailored surveillance is recommended.

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Section: Discussionmentioning

confidence: 99%

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

et al. 2020

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“…Estimates from French cancer registries imply a similar situation with e.g. a 10.5% and 11.3% cumulative incidence of UBC in men at 10 years after a first diagnosis of lung and prostate cancer, respectively [9]. UBC as a secondary primary malignancy is especially common after cancers of the lung and bronchus, head and neck and stomach cancer, with which there is a shared strong association with tobacco smoking [1–3].…”

Section: Discussionmentioning

confidence: 91%

Treatment and prognosis of patients with urinary bladder cancer with other primary cancers: a nationwide population‐based study in the Bladder Cancer Data Base Sweden (BladderBaSe)

et al. 2020

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To study how patients with urinary bladder cancer (UBC) with previous or concomitant other primary cancers (OPCs) were treated, and to investigate their prognosis. Patients And Methods Using nationwide population-based data in the Bladder Cancer Data Base Sweden (BladderBaSe), we analysed the probability of treatment with curative intent, and UBC-specific and overall survival (OS) in patients with UBC diagnosed in the period 1997-2014 with or without OPC. The analyses considered the patient's characteristics, UBC tumour stage at diagnosis, and site of OPC. Results There were 38 689 patients, of which 9804 (25%) had OPCs. Those with synchronous OPCs more often had T2 and T3 tumours and clinically distant disease at diagnosis than those with UBC only. Patients with synchronous prostate cancer, female genital cancer and lower gastro-intestinal cancer were more often treated with curative intent than patients with UBC only. When models of survival were adjusted for age at diagnosis, marital status, education, year of diagnosis, Charlson Comorbidity Index and T-stage, UBC-specific survival was similar to patients with UBC only, but OS was lower for patients with synchronous OPC, explained mainly by deaths in OPC primaries with a bad prognosis. Conclusions OPC is common in patients with UBC. Treatment for UBC, after or in conjunction with an OPC, should not be neglected and carries just as high a probability of success as treatment in patients with UBC only. The needs of patients with UBC and OPC, and optimisation of their treatment considering their complicated disease trajectory are important areas of research.

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Models of Long-Term Follow-up for Cancer Patients: From Children to Adults, from Simple to Multi-Modal

Berger

2021

Survivorship Care for Cancer Patients

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Development of a model to predict the 10-year cumulative risk of second primary cancer among cancer survivors

Cited by 11 publications

References 20 publications

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

Second primary tumors in head and neck cancer patients: The importance of a “tailored” surveillance

Treatment and prognosis of patients with urinary bladder cancer with other primary cancers: a nationwide population‐based study in the Bladder Cancer Data Base Sweden (BladderBaSe)

Models of Long-Term Follow-up for Cancer Patients: From Children to Adults, from Simple to Multi-Modal

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