Adherence to Mediterranean diet and risk of developing cognitive disorders: An updated systematic review and meta-analysis of prospective cohort studies

Wu, Lei; Sun, Dingyong

doi:10.1038/srep41317

Cited by 153 publications

(105 citation statements)

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“…26 In contrast, Alzheimer's disease was inversely associated with MED in both high vs low comparisons as well as on a continuous scale. 26 For every 1-unit increase in the MED, there was an 8% reduction in Alzheimer's disease risk (RR 0.92, 95% CI 0.86 to 0.99).…”

Section: Research Snapshotmentioning

confidence: 88%

“…Fifteen were either earlier publications from the same group of researchers with updates available, included fewer individual cohort studies in the summary risk estimates, or were high vs low comparisons of risk of a health outcome when a doseeresponse analysis for the same health outcome was available. A summary of the seven studies (2 studies with HEI 21,22 and 5 studies with MED [23][24][25][26][27] ) included in the current model is provided in Table 1. It is important to note that based on the inclusion criteria, no studies on the association between conformance with a vegetarian dietary pattern and health outcomes were identified.…”

Section: Research Snapshotmentioning

confidence: 99%

“…Three meta-analyses quantified the association between MED and cognitive disorders with disease end points including mild cognitive impairment, Alzheimer's disease, and dementia. 26,35,36 The most recent meta-analysis by Wu and Sun 26 reported a significant inverse association between MED and mild cognitive impairment but when analyzed as a doseeresponse linear relationship, the association was no longer observed (RR 0.97, 95% CI 0.78 to 1.17). 26 In contrast, Alzheimer's disease was inversely associated with MED in both high vs low comparisons as well as on a continuous scale.…”

Section: Research Snapshotmentioning

confidence: 99%

“…26,35,36 The most recent meta-analysis by Wu and Sun 26 reported a significant inverse association between MED and mild cognitive impairment but when analyzed as a doseeresponse linear relationship, the association was no longer observed (RR 0.97, 95% CI 0.78 to 1.17). 26 In contrast, Alzheimer's disease was inversely associated with MED in both high vs low comparisons as well as on a continuous scale. 26 For every 1-unit increase in the MED, there was an 8% reduction in Alzheimer's disease risk (RR 0.92, 95% CI 0.86 to 0.99).…”

Section: Research Snapshotmentioning

confidence: 99%

See 3 more Smart Citations

Health Economic Evaluation Modeling Shows Potential Health Care Cost Savings with Increased Conformance with Healthy Dietary Patterns among Adults in the United States

Scrafford¹,

Bi²,

Multani³

et al. 2019

Journal of the Academy of Nutrition and Dietetics

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Section: Research Snapshotmentioning

confidence: 88%

Section: Research Snapshotmentioning

confidence: 99%

Section: Research Snapshotmentioning

confidence: 99%

Section: Research Snapshotmentioning

confidence: 99%

See 2 more Smart Citations

Health Economic Evaluation Modeling Shows Potential Health Care Cost Savings with Increased Conformance with Healthy Dietary Patterns among Adults in the United States

Scrafford¹,

Bi²,

Multani³

et al. 2019

Journal of the Academy of Nutrition and Dietetics

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“…The HRs were higher in the USA compared to Asia and Europe. It is proposed that the American people are different from Asian and European people with respect to lifestyle, dietary habits, and genetic background [48,63]. The difference between DASH diet scoring methods at least in part might also explain the heterogeneity between studies.…”

Section: Discussionmentioning

confidence: 99%

Adherence to the dietary approaches to stop hypertension (DASH) diet in relation to all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective cohort studies

Soltani

Arablou

Jayedi

et al. 2020

Nutr J

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Background: Although previous investigations have proposed an association between Dietary Approaches to Stop Hypertension (DASH)-style diet and lower mortality from chronic diseases, the exposure-response relationship is not clear. The present systematic review and meta-analysis aimed to explore the linear and non-linear doseresponse association between adherence to the DASH diet and all-cause and cause-specific mortality.Methods: Database search was performed in PubMed, Scopus, and EMBASE for prospective cohort studies investigating the association between adherence to the Dietary Approaches to Stop Hypertension (DASH) diet and risk of mortality. Summary hazard ratios (HRs) and 95% confidence intervals (CI) were estimated with the use of a random-effects model for the linear and nonlinear relationships. The two-stage hierarchical regression model was applied to test the potential non-linear dose-response associations. Results: The inclusion criteria were met by 17 studies (13 publications). The scores reported for adherence to the DASH diet in different studies were converted to a conventional scoring method in which the adherence score might range between 8 to 40. The linear analysis revealed that summary HRs were 0.95 (95% CI: 0.94-0.96, I 2 = 91.6%, n = 14) for all-cause, 0.96 (95% CI: 0.95-0.98, I 2 = 82.4%, n = 12) for CVD, 0.97 (95% CI: 0.96-0.98, I 2 = 0.00%, n = 2) for stroke, and 0.97 (95% CI: 0.95-0.98, I 2 = 63.7%, n = 12) for cancer mortality per each 5-point increment of adherence to the DASH diet. There was also evidence of non-linear associations between the DASH diet and allcause and cause-specific mortality as the associations became even more evident when the adherence scores were more than 20 points (P < 0.005).Conclusion: Even the modest adherence to the DASH diet is associated with a lower risk of all-cause and causespecific mortality. The higher adherence to the diet also strengthens the risk-reducing association.(Continued on next page)

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Association of Midlife Diet With Subsequent Risk for Dementia

Akbaraly

Singh‐Manoux

Dugravot

et al. 2019

JAMA

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Importance Observational studies suggest that diet is linked to cognitive health. However, the duration of follow-up in many studies is not sufficient to take into account the long preclinical phase of dementia and the evidence from intervention studies is not conclusive. Objectives To examine whether midlife diet is associated with subsequent risk of dementia. Design, Setting and Participants Population-based cohort study established in 1985-1888, with dietary intake assessment in 1991-1993, 1997-1999 and 2002-2004; follow-up for incident dementia until March 2017. Exposures Food frequency questionnaire to derive the Alternate Healthy Eating Index (AHEI), an 11-component diet quality score (range=0-110), with higher scores indicating a healthier diet. Main Outcome and Measures Incident dementia ascertained through linkage to electronic health records. Results Among 8225 (mean age 50.2 (SD, 6.1) years; 5686, 69.1% men) dementia-free participants in 1991-1993 a total of 344 cases of incident dementia were recorded over a median follow-up of 24.8 (IQR, 24.2 to 25.1) years. No significant difference in incidence rate (IR) of dementia was observed in tertiles of AHEI exposure in 1991-1993, 1997-1999 (median follow-up 19.1 years) and 2002-2004 (median follow-up 13.5 years). Compared with IR of dementia of 1.76 (95% CI, 1.47-2.12) per 1000 person-years in the worst tertile of AHEI (lowest tertile of diet quality) in 1991-1993, the absolute rate differences for the intermediate and the best tertiles were, respectively, 0.03 (95 % CI, -0.43 to 0.49) and 0.04 (95% CI, -0.42 to 0.51) per 1000 person-years. In 1997-1999, the absolute rate differences in the intermediate and the best AHEI tertiles compared to the worst tertile (IR=2.06 (95% CI, 1.62-2.61) per 1000 person-years) were respectively 0.14 (95 % CI, -0.58 to 0.86) and 0.14 (95% CI, -0.58 to 0.85) per 1000 person-years. In 2002-2004, these absolute rate differences with the worst AHEI tertile (IR=3.12 (95% CI, 2.49-3.92) per 1000 person-years) were respectively -0.61 (95 % CI, -1.56 to 0.33) and -0.73 (95% CI, -1.67 to 0.22) per 1000 person-years in the intermediate and best AHEI tertiles. In multivariate analysis, HRs of dementia per 10-point AHEI increment were not significant as assessed in 1991-1993 (0.97, 95% CI, 0.87-1.08)), in 1997-1999 (0.97, 95% CI, 0.83-1.12)), or in 2002-2004 (0.87, 95% CI, 0.75-1.00)). Conclusion In this long-term prospective cohort study, diet quality assessed in midlife was not significantly associated with subsequent risk of dementia.

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Adherence to Mediterranean diet and risk of developing cognitive disorders: An updated systematic review and meta-analysis of prospective cohort studies

Cited by 153 publications

References 50 publications

Health Economic Evaluation Modeling Shows Potential Health Care Cost Savings with Increased Conformance with Healthy Dietary Patterns among Adults in the United States

Health Economic Evaluation Modeling Shows Potential Health Care Cost Savings with Increased Conformance with Healthy Dietary Patterns among Adults in the United States

Adherence to the dietary approaches to stop hypertension (DASH) diet in relation to all-cause and cause-specific mortality: a systematic review and dose-response meta-analysis of prospective cohort studies

Association of Midlife Diet With Subsequent Risk for Dementia

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