Solute and Water Transport in Peritoneal Dialysis: A Case-Based Primer

Khanna, Ramesh

doi:10.1053/j.ajkd.2016.11.007

Cited by 17 publications

(6 citation statements)

References 18 publications

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“…A dialysate is introduced within the peritoneal cavity, allowing excess fluid and waste from the blood vessels to pass through the peritoneal membrane by diffusion. 21 The dialysate is later drained and replaced with a fresh one.…”

Section: Current Treatment For Ckd and Esrdmentioning

confidence: 99%

Renal tissue engineering for regenerative medicine using polymers and hydrogels

2023

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Section: Current Treatment For Ckd and Esrdmentioning

confidence: 99%

Renal tissue engineering for regenerative medicine using polymers and hydrogels

2023

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“…therapy and its prevalence after initiation of PD ranges from 5 to 10% [9][10][11]. When PD is initiated, the therapy can effectively control potassium levels and the process of removal occurs mainly by diffusion, given that PD solutions are characteristically free of potassium [12]. In contrast, the transport by convection is minimal: the estimated potassium removal with 1L of ultrafiltration range only from 3 to 7 mEq depending on the potassium serum concentration [12].…”

Section: Plos Onementioning

confidence: 99%

“…In contrast to small molecules, the transport of middle size molecules through the peritoneal membrane demands more time to achieve balance [12]. Phosphate is a good example to…”

Section: Plos Onementioning

confidence: 99%

Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels

et al. 2021

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Peritoneal dialysis (PD) modalities affect solute removal differently. However, the impacts of switching PD modalities on serum levels of biomarkers of different sizes are not known. Our objective was to analyze whether a change in the PD modality associates with the levels of two routine biochemical laboratories. In this multicentric prospective cohort study. we selected all patients who remained on a PD modality for at least 6 months and switched PD modality. Patients were also required to be treated with the same PD modality for at least 3 months before and after the modality change. The primary outcome was change in potassium and phosphate serum levels. We identified 737 eligible patients who switched their PD modality during the study. We found mean serum phosphate levels increased during the 3 months after switching from CAPD to APD and conversely decreased after switching to from APD to CAPD. In contrast, for potassium the difference in the mean serum levels was comparable between groups switching from CAPD to APD, and vice versa. In conclusion, CAPD seems to be as efficient as APD for the control of potassium serum levels, but more effective for the control of phosphate serum levels. The effect of a higher removal of middle size molecules as result of PD modalities in terms of clinical and patient-reported outcomes should be further explored.

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“…PD works by taking advantage of the peculiar characteristics of the peritoneal membrane (PM) constituted by a monolayer of mesothelial cells (MC) sustained by a submesothelial zone composed of a matrix containing fibroblasts, collagen, and other extracellular matrix material, at the bottom of which there is a dense network of capillaries [ 3 ]. This complex structure is semipermeable and highly vascularized, allowing ultrafiltration and solute removal through the exchanges of a dialysis solution into the peritoneal cavity [ 4 ]. The PD solutions consist of physiological concentrations of chloride, calcium, sodium, and magnesium, as well as buffers (lactate and/or bicarbonate) and an osmotic vehicle (glucose is the most used) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Proteomics and Extracellular Vesicles as Novel Biomarker Sources in Peritoneal Dialysis in Children

Trincianti

Meleca

Porta

et al. 2022

IJMS

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Peritoneal dialysis (PD) represents the dialysis modality of choice for pediatric patients with end-stage kidney disease. Indeed, compared with hemodialysis (HD), it offers many advantages, including more flexibility, reduction of the risk of hospital-acquired infections, preservation of residual kidney function, and a better quality of life. However, despite these positive aspects, PD may be associated with several long-term complications that may impair both patient’s general health and PD adequacy. In this view, chronic inflammation, caused by different factors, has a detrimental impact on the structure and function of the peritoneal membrane, leading to sclerosis and consequent PD failure both in adults and children. Although several studies investigated the complex pathogenic pathways underlying peritoneal membrane alterations, these processes remain still to explore. Understanding these mechanisms may provide novel approaches to improve the clinical outcome of pediatric PD patients through the identification of subjects at high risk of complications and the implementation of personalized interventions. In this review, we discuss the main experimental and clinical experiences exploring the potentiality of the proteomic analysis of peritoneal fluids and extracellular vesicles as a source of novel biomarkers in pediatric peritoneal dialysis.

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Solute and Water Transport in Peritoneal Dialysis: A Case-Based Primer

Cited by 17 publications

References 18 publications

Renal tissue engineering for regenerative medicine using polymers and hydrogels

Renal tissue engineering for regenerative medicine using polymers and hydrogels

Peritoneal dialysis modality transition and impact on phosphate and potassium serum levels

Proteomics and Extracellular Vesicles as Novel Biomarker Sources in Peritoneal Dialysis in Children

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