<b>Asthma</b>–<b>COPD overlap syndrome showed more exacerbations however lower mortality than COPD</b>

Bai, Jing; Mao, Baohua; Yang, Wenlan; Liang, Shuo; Lu, Hai‐Wen; Xu, Jin

doi:10.1093/qjmed/hcx005

Cited by 16 publications

(14 citation statements)

References 15 publications

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“…This compares with data available from China and the American continents, but contrasts with data available from other studies where no association was found between ACOS and exacerbation rates. [ 12 16 17 18 19 ] However, the criteria used to define ACOS may explain the difference recorded between our study and earlier studies. [ 20 ]…”

Section: Discussioncontrasting

confidence: 70%

Predictors of asthma-chronic obstructive pulmonary disease overlap syndrome in patients with chronic obstructive pulmonary disease from a tertiary care center in India

et al. 2018

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Section: Discussioncontrasting

confidence: 70%

Predictors of asthma-chronic obstructive pulmonary disease overlap syndrome in patients with chronic obstructive pulmonary disease from a tertiary care center in India

et al. 2018

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“…Older age has been identified as a risk factor associated with a higher prevalence of mortality in COPD patients. 19 , 20 Age (hazard ratio, 1.139; 95% confidence interval, 1.077–1.204; P <0.001) was independently associated with mortality from COPD. Many COPD patients simultaneously suffer from malignant tumor, cardiovascular disease, and other system diseases related to smoking, and these further affect the patients’ prognosis and survival time.…”

Section: Discussionmentioning

confidence: 99%

Smoking cessation affects the natural history of COPD

Bai¹,

Chen²,

Liu³

et al. 2017

COPD

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BackgroundCigarette smoking is the most commonly encountered and readily identifiable risk factor for COPD. However, it is not clear which quantitative factors related to smoking influence the prognosis of COPD patients.MethodsA total of 204 patients with a long-term history of smoking were enrolled into this study and followed up for 5 years. Patients were divided into “death” or “survival” groups based on follow-up results and “quitting-smoking” or “continuing-smoking” groups based on whether they gave up smoking.ResultsPatients in the death group had a longer smoking time, lower prevalence of quitting smoking, later onset of COPD symptoms, older age at quitting smoking, lower forced expiratory volume in one second (FEV1) % predicted, and lower ratio of FEV1/forced vital capacity. Age, age at quitting smoking, and FEV1% predicted were independently associated with mortality from COPD. Compared to the continuing-smoking group, the quitting-smoking group had a lower mortality rate, longer course of COPD, earlier onset of COPD symptoms, and lower residual volume percent predicted. During the 5-year follow-up, 113 deaths were recorded (quitting-smoking group: n=92; 40 deaths; continuing-smoking group: n=112; 73 deaths). The mortality risk remained significantly higher in the continuing-smoking group than the quitting-smoking group (log-rank test, 13.59; P=0.0002).ConclusionSmoking time may be related to the mortality rate from COPD. Smoking cessation has the greatest capacity to influence the natural history of COPD.

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“… 4 – 8 The case of ACO is more controversial. While some authors report a higher incidence of exacerbation 9 , 10 and mortality in this phenotype, 11 , 12 others have not detected a higher incidence of exacerbations. 13 Compared with the other phenotypes of COPD, ACO has even been reported to have a “protective effect” against mortality.…”

Section: Introductionmentioning

confidence: 84%

“…Similar results were reported by Calle Rubio et al, 18 although this finding was not reported elsewhere. 10 , 14 …”

Section: Discussionmentioning

confidence: 99%

COPD phenotypes: differences in survival

Vázquez

García

Jiménez‐García

et al. 2018

COPD

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BackgroundThe aim of the study was to analyze the characteristics and survival of a group of patients with COPD according to their clinical phenotype.Patients and methodsThe study population was selected from patients undergoing scheduled spirometry between January 1, 2011 and June 30, 2011 at the respiratory function laboratory of a teaching hospital and comprised those with a previous and confirmed diagnosis of COPD and forced expiratory volume in the first second (FEV1) of <70%. The patients selected were classified into 4 groups: positive bronchodilator response, non-exacerbator, exacerbator with emphysema, and exacerbator with chronic bronchitis. Patients were followed up until April 2017.ResultsWe recruited 273 patients, of whom 89% were men. The distribution by phenotype was as follows: non-exacerbator, 47.2%; positive bronchodilator response, 25.8%; exacerbator with chronic bronchitis, 13.8%; and exacerbator with emphysema, 13.0%. A total of 90 patients died during follow-up (32.9%). Taking patients with a positive bronchodilator response as the reference category, the risk factors that were independently associated with death were older age (HR, 1.06; 95% CI, 1.03–1.09), lower FEV1 (HR, 0.98; 95% CI, 0.96–0.99), and exacerbator with chronic bronchitis phenotype (HR, 3.28; 95% CI, 1.53–7.03).ConclusionClassification of COPD patients by phenotype makes it possible to identify subgroups with different prognoses. Thus, mortality was greater in exacerbators with chronic bronchitis and lower in those with a positive bronchodilator response.

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Asthma–COPD overlap syndrome showed more exacerbations however lower mortality than COPD

Abstract: Patients with ACOS were more likely to have better prognoses and lower mortality than those with COPD alone, though with greater exacerbation frequency.

Cited by 16 publications

References 15 publications

Predictors of asthma-chronic obstructive pulmonary disease overlap syndrome in patients with chronic obstructive pulmonary disease from a tertiary care center in India

Predictors of asthma-chronic obstructive pulmonary disease overlap syndrome in patients with chronic obstructive pulmonary disease from a tertiary care center in India

Smoking cessation affects the natural history of COPD

COPD phenotypes: differences in survival

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