281: Worsening anxiety after initiation of elexacaftor/tezacaftor/ivacaftor in an adult cohort of patients with cystic fibrosis

Questions and Answers? Depression Symptoms Associated with Elexacaftor/Tezacaftor/Ivacaftor Treatment for Cystic Fibrosis

“…Zhang and colleagues ( 13 ) reported that although there was no overall significant change in PHQ-9 score, 5% of patients received new mental health diagnoses, and 22% increased, switched, or added psychotropic drugs, suggesting that a subgroup may have had worsening depression symptoms. Pudukodu and colleagues ( 14 ) focused their analysis on data that were exclusively prepandemic and reported that 21% of patients initiating ELX/TEZ/IVA therapy had significant increases in PHQ-9 score, balanced by 18% who had significant decreases. A study by Sakon and colleagues ( 15 ), although showing a reassuring mean decrease in PHQ-9 score of −1.11, saw a range of −22 to +14, and 9% of respondents reported that ELX/TEZ/IVA therapy had been associated with a decline in mental health.…”