Development of poly(lactide‐co‐glycolide) nanoparticles functionalized with a mitochondria penetrating peptide

Selmin, Francesca; Magri, Giulia; Gennari, C.; Marchianò, Silvia; Ferri, Nicola; Pellegrino, Sara

doi:10.1002/psc.2952

Cited by 9 publications

(5 citation statements)

References 31 publications

(33 reference statements)

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“…The reagents and solvents were purchased from Sigma Aldrich and used without additional purification. 1 H NMR spectra were recorded at 300 MHz and 13 C NMR spectra at 75 MHz using TMS as internal standard. Mass spectra were recorded under electron spray interface (ESI) conditions.…”

Section: Methodsmentioning

confidence: 99%

“…3,4,10 NP + can be also obtained by the functionalization of anionic or neutral polymers with cell penetrating peptides, i. e. positively charged oligopeptides composed mainly by Arginine and/or Lysine residues. [11][12][13][14][15][16] In all cases, the polymer is the molecular tool that direct the process of self-assembly while the cationic charge decorates the NP + .…”

Section: Introductionmentioning

confidence: 99%

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Self-assembly of an amphipathic ααβ-tripeptide into cationic spherical particles for intracellular delivery

et al. 2017

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The development of molecular carriers able to carry molecules directly into the cell is an area of intensive research. Cationic nanoparticles are effective delivery systems for several classes of molecules, such as anticancer agents, oligonucleotides and antibodies. Indeed, a cationic charge on the outer surface allows a rapid cellular uptake together with the possibility of carrying negatively charged molecules. In this work, we studied the self-assembly of an ultra-short ααβ-tripeptide containing an l-Arg-l-Ala sequence and an unnatural fluorine substituted β-diaryl-amino acid. The presence of the unnatural β-diaryl-amino acid allowed us to obtain a protease stable sequence. Furthermore, an arginine guanidinium group triggered the formation of spherical assemblies that were able to load small molecules and enter cells. These spherical architectures, thus, represent interesting candidates for the delivery of exogenous entities directly into cells.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Self-assembly of an amphipathic ααβ-tripeptide into cationic spherical particles for intracellular delivery

et al. 2017

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“…Given the special properties of these two components, MPPs are skilled at passing across the cell and mitochondria membranes (Jean et al, 2016). Selmin et al developed a mitochondria-targeting hybrid polymer via functionalized PLGA with 6-mer MPP peptide for the first time (Selmin et al, 2017). The 6-mer MPP peptide is composed of alternating arginine and cyclohexylalanine, realizing successful entering the cells and mitochondria.…”

Section: Active Mitochondria-targeted Delivery Based On Peptidesmentioning

confidence: 99%

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Sun

Yang

Xia

et al. 2021

Front. Bioeng. Biotechnol.

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Despite all sorts of innovations in medical researches over the past decades, cancer remains a major threat to human health. Mitochondria are essential organelles in eukaryotic cells, and their dysfunctions contribute to numerous diseases including cancers. Mitochondria-targeted cancer therapy, which specifically delivers drugs into the mitochondria, is a promising strategy for enhancing anticancer treatment efficiency. However, owing to their special double-layered membrane system and highly negative potentials, mitochondria remain a challenging target for therapeutic agents to reach and access. Polymeric nanoparticles exceed in cancer therapy ascribed to their unique features including ideal biocompatibility, readily design and synthesis, as well as flexible ligand decoration. Significant efforts have been put forward to develop mitochondria-targeted polymeric nanoparticles. In this review, we focused on the smart design of polymeric nanosystems for mitochondria targeting and summarized the current applications in improving cancer therapy.

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“…To date, various types of lipid carriers have been described that are characterized by different lipid composition and parameters of transfection efficacy. The next step in improving the nanocarrier design will be the use of specific mitochondria‐targeting molecules 89,109,110 …”

Section: Lipid Carriers For Gene Delivery To Mitochondriamentioning

confidence: 99%

Lipid‐based gene delivery to macrophage mitochondria for atherosclerosis therapy

Zakirov

Zhang

Grechko

et al. 2020

Pharmacology Res & Perspec

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Atherosclerosis with associated cardiovascular diseases remains one of the main causes of disability and death worldwide, requiring development of new solutions for prevention and treatment. Macrophages are the key effectors of a series of events involved in atherogenesis, such as inflammation, plaque formation, and changes in lipid metabolism. Some of these events were shown to be associated with mitochondrial dysfunction and excessive mitochondrial DNA (mtDNA) damage. Moreover, macrophages represent a promising target for novel therapeutic approaches that are based on the expression of various receptors and nanoparticle uptake. Lipid‐based gene delivery to mitochondria is considered to be an interesting strategy for mtDNA damage correction. To date, several nanocarriers and their modifications have been developed that demonstrate high transfection efficiency and low cytotoxicity. This review discusses the possibilities of lipid‐based gene delivery to macrophage mitochondria for atherosclerosis therapy.

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Development of poly(lactide‐co‐glycolide) nanoparticles functionalized with a mitochondria penetrating peptide

Cited by 9 publications

References 31 publications

Self-assembly of an amphipathic ααβ-tripeptide into cationic spherical particles for intracellular delivery

Self-assembly of an amphipathic ααβ-tripeptide into cationic spherical particles for intracellular delivery

Polymeric Nanoparticles for Mitochondria Targeting Mediated Robust Cancer Therapy

Lipid‐based gene delivery to macrophage mitochondria for atherosclerosis therapy

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