Comparative analysis of NK cell receptor repertoire in adults and very elderly subjects with cytomegalovirus infection

Juárez‐Vega, Guillermo; Rangel-Ramírez, Velia Verónica; Monsiváis‐Urenda, Adriana; Niño-Moreno, Perla; García-Sepúlveda, Christian A.; Noyola, Daniel E.; González‐Amaro, Roberto

doi:10.1016/j.humimm.2017.01.004

Cited by 4 publications

(9 citation statements)

References 32 publications

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“…Therefore, the magnitudes of the specific immune responses from NK cells are likely graded depending on repertoire of activating receptors expressed and utilized ( 22 , 78 ). Of note, NKG2C genotype may contribute/modulate the expansion of NKG2C + NK cells ( 31 – 33 , 36 , 94 ); however, in our study, we did not perform individual genotyping of the NKG2C gene. The Mtb strains are another important variable as strains have been shown to be associated with variation in IFNγ production in response to Mtb antigens ( 95 ); unfortunately, data on the strains were not available for the current study.…”

Section: Discussionmentioning

confidence: 88%

“…In response to CHIKV infection, the repertoire of NK cell receptors (activating and inhibitory) has been shown to be modulated; the increased in NKG2C + NK cells with infection correlates with viral load ( 28 ). In addition, NKG2C genotype could be associated with disease state ( 31 , 32 ) and may affect the frequency of NKG2C + NK cells in adults ( 33 ). For example, deletion of the KLRC2 gene, which encodes NKG2C, is associated with psoriasis ( 34 ) and may have a role in the control of HCMV in children ( 35 ) but not in bacterial infection caused by Chlamydia trachomatis ( 32 ).…”

Section: Introductionmentioning

confidence: 99%

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Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease

et al. 2018

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Tuberculosis (TB) is still a global health concern, especially in resource-poor countries such as The Gambia. Defining protective immunity to TB is challenging: its pathogenesis is complex and involves several cellular components of the immune system. Recent works in vaccine development suggest important roles of the innate immunity in natural protection to TB, including natural killer (NK) cells. NK cells mediate cellular cytotoxicity and cytokine signaling in response to Mycobacterium tuberculosis (Mtb). NK cells can display specific memory-type markers to previous antigen exposure; thus, bridging innate and adaptive immunity. However, major knowledge gaps exist on the contribution of NK cells in protection against Mtb infection or TB. We performed a cross-sectional assessment of NK cells phenotype and function in four distinct groups of individuals: TB cases pre-treatment (n = 20) and post-treatment (n = 19), and household contacts with positive (n = 9) or negative (n = 18) tuberculin skin test (TST). While NK cells frequencies were similar between all groups, significant decreases in interferon-γ expression and degranulation were observed in NK cells from TB cases pre-treatment compared to post-treatment. Conversely, CD57 expression, a marker of advanced NK cells differentiation, was significantly lower in cases post-treatment compared to pre-treatment. Finally, NKG2C, an activation and imprinted-NK memory marker, was significantly increased in TST+ (latently infected) compared to TB cases pre-treatment and TST− (uninfected) individuals. The results of this study provide valuable insights into the role of NK cells in Mtb infection and TB disease, demonstrating potential markers for distinguishing between infection states and monitoring of TB treatment response.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease

et al. 2018

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“…According to Juárez-Vega, et al (2017), besides NKG2C+ NK cells, a subset of NK cells termed CD16 was also found to be elevated in the elderly (33). Furthermore, Muccio, et al (2016) also reported that HCMVreactivating individuals had higher frequencies of these distinct NK cell subgroups than non-reactivating individuals in the pediatric sample (36).…”

Section: Literature Reporting Changes In Nk Cell Expression In People...mentioning

confidence: 99%

“…All 21 publications reported a significant increase in NK cell expression in individuals with HCMV infection. Of these papers, six specifically reported NK cell expression in people with HCMV of different age ranges (32)(33)(34)(35)(36)(37). Muccio, et al (2016) reported the development of NK cells in pediatric patients with hematological malignancies (n=7) while another five investigated NK cell receptor repertoire in adults and elderly subjects with HCMV, stipulating significant expansion in the level of NKG2C+ NK cells in the elderly compared to young adults (36).…”

Section: Literature Reporting Changes In Nk Cell Expression In People...mentioning

confidence: 99%

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Characterization of the Adaptive Nkg2c+ Nk Cell in Human Cytomegalovirus Infected Individuals: A Systematic Review

Okpoluaefe,

Mahmad-Najhan,

Hassan

2023

JUMMEC

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The significance of adaptive natural killer (NK) cells in the subject pertaining to human cytomegalovirus (HCMV) infection is emphasized by the preferential expansion of a specific subset, termed NKG2C+ which can recognize an array of HCMV-encoded proteins. Until today, the subject of adaptive or ‘memory-like’ NK cells remains controversial, but more emerging evidence shows the cells' ability to ‘remember’. The purpose of this systematic review was to appraise recent literature that centered on the expansion of adaptive NKG2C+ NK cells driven by HCMV infection, specific to ‘human’. Databases including PubMed, Scopus, and JURN were systematically searched to source relevant journal articles published between 2011 and 2021, in a period of 10 years. Full-text terms such as ‘NKG2C+ adaptive NK cells’ AND ‘human cytomegalovirus’ were applied to retrieve related articles. This systematic review is comprised of continuous data on the expansion of NKG2C+ NK cells driven by HCMV and other HCMV-affiliated receptors, immune cells, and diseases with appropriate implementation of distinct inclusion and exclusion criteria. The authors evaluated the risk of bias and quality evidence of the data independently. The study is beneficial by gathering the evidence to conclude the occurrence of adaptive or ‘memory-like’ properties in human NK cells.

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Adaptive natural killer cell expression in response to cytomegalovirus infection in blood and solid cancer

Okpoluaefe,

Ismail,

Mohamed

et al. 2024

Heliyon

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Comparative analysis of NK cell receptor repertoire in adults and very elderly subjects with cytomegalovirus infection

Cited by 4 publications

References 32 publications

Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease

Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease

Characterization of the Adaptive Nkg2c+ Nk Cell in Human Cytomegalovirus Infected Individuals: A Systematic Review

Adaptive natural killer cell expression in response to cytomegalovirus infection in blood and solid cancer

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