Italian patients with more recent onset of Major Depressive Disorder have a shorter duration of untreated illness

Dell’Osso, Bernardo; Cremaschi, Laura; Grancini, Benedetta; Cagna, F. De; Benatti, Beatrice; Camuri, G.; Arici, C.; Dobrea, Cristina; Oldani, Lucio; Palazzo, Marco; Vismara, Matteo; Altamura, Alfredo Carlo

doi:10.1111/ijcp.12926

Cited by 9 publications

(5 citation statements)

References 40 publications

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“…The mean DUI in our sample was 77.2 ± 103.0 months and was significantly longer for BD‐II, compared to BD‐I, BD‐NOS and cyclothymia patients. In previous studies by our group (Altamura et al, 2007, 2015), we reported a mean DUI around 80 months in BD patients, with some data suggesting a reduction in DUI over time in recent years (Dell'sso et al, 2017). Confirming the potential risk of mistreatment and delayed treatment in BD patients with ADs at onset, the DUI was significantly longer in A+ vs A− patients in the present study.…”

Section: Discussionmentioning

confidence: 48%

Clinical features and patterns of psychopharmacological prescription in bipolar patients with vs without anxiety disorders at onset

Galimberti

Caricasole

Bosi

et al. 2019

Early Intervention Psych

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Aim: Up to just over half of bipolar disorder (BD) patients report at least one-lifetime anxiety disorder (AD). In some, anxiety represents the earliest psychiatric manifestation, prior to any mood episode. We sought to investigate prevalence of AD subtypes as first psychiatric manifestations and AD's relations with duration of untreated illness (DUI) and treatment among BD outpatients. Methods: We recruited patients referred to the Centre for the Treatment of Depressive Disorders in Milan, diagnosed with BD-I, BD-II, BD not otherwise specified (BD-NOS) and cyclothymia according to Diagnostic and Statistical Manual fourth edition-text revision criteria. Several clinical characteristics were assessed through retrospective chart review and/or direct patient interviews. Based on presence/ absence of an AD at psychiatric onset, eligible subjects were stratified into two groups (A+ and A−) and clinical features were compared between these groups and between BD subtypes. Results: We analysed 260 BD patients (77 BD-I, 122 BD-II, 45 BD-NOS and 16 cyclothymia). An AD was the first psychiatric manifestation in 69 patients (26.5%). BD-II and BD-NOS more frequently had an AD at psychiatric onset, with panic disorder being the most common AD. Among A+ vs A−, age at BD onset was younger, duration of untreated BD illness (DUI) was longer, and a mood stabilizer/antipsychotic was less often prescribed at psychiatric onset.

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Section: Discussionmentioning

confidence: 48%

Clinical features and patterns of psychopharmacological prescription in bipolar patients with vs without anxiety disorders at onset

Galimberti

Caricasole

Bosi

et al. 2019

Early Intervention Psych

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“…74 what is of interest is that there was even a signi cant decrease in DUI in the major depressive disorder groups whose onset occurred prior to the last century vs,as reported in an Italy study. 75 larger samples in different regions and time periods with targeted cognitive questionnaire and are warranted to con rm these results in DUI in further studies…”

Section: Duration Of Untreated Diseasementioning

confidence: 73%

Duration of untreated illness; year of onset early/late and Gender differences, symptoms in patients with Major depressive disorder. an eighteen month, cross-sectional, clinical study in southwest China

Cao

Liu

Duan

et al. 2023

Preprint

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Objective: Previous studies have reported differences between adolescent-depression and adult- onset depression with respect to demographic and clinical symptoms. However, it remains unclear whether these sex and age of onset differences can be detected in regular scales based on symptom traits. The comparition of symptoms between early-onset (male/female) and late-onset (male/female) Chinese MDD patients was performed in the present study. Methods/Study protocol: The present cross-sectional study was conducted in the psychiatric department of the sixth affiliated hospital at Kunming Medical University from Sep 2020 to Mar 2022. We recruited 229 outpatients with a first diagnosis of MDD .Two groups differed on seven-dimensional symptoms on the Hamilton Depression Rating Scale (HAMD-24) in addition, correlations between seven-dimensional symptoms were compared across two groups.Principal components analysis (PCA) was conducted to assess sex, SAS and SDS differences between two groups. Results: 1.Early-onset cases have a high score in Hopelessness score (p=0.049), whereas females have a higher score in Anxiety somatization score (p=0.005) and sleep disturbances（p=0.007），There was no significant symptom difference in symptoms between the groups and other symptoms. 2.female(p＜0.01) and early-onset（p＜0.05）are risk factors for hopelessness in MDD, female（p＜0.05）is a risk factor of sleep disturbances in late-onset MDD, early-onset（p＜0.05）is a risk factor of cognitive impairment restrict in female in MDD. 3.we found no significant goodness of fit and predictive power in 4 groups categorized by year of onset. Conclusion: larger samples sizes in different regions and time periods with targeted cognitive questionnaire are warranted to redress the new nosology in early-onset MDD based on DUI in additional studies2.Late-onset female patients show less cognitive impairment and more sleep disorder.3.the female and early onset year are risk factors in the hopelessness score in cases of MDD. Trial entry: China Clinical Trials.gov 908236120030

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“…Furthermore, the mean duration of illness in this study (25.00 months) was longer than those of previous studies (mean = 0.7 years). Previous studies have also indicated that duration of illness can affect adverse consequences in terms of outcome for individuals with MDD (47). Therefore, it is reasonable to assume that these inconsistencies in results are due to differences in age of subjects and the duration of their illness.…”

Section: Discussionmentioning

confidence: 99%

Repetitive Transcranial Magnetic Stimulation Improves Amygdale Functional Connectivity in Major Depressive Disorder

Chen¹,

Gu²,

Zhai

et al. 2020

Front. Psychiatry

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Emotional abnormality in major depressive disorder (MDD) is generally regarded to be associated with functional dysregulation in the affective network (AN). The present study examined the changes in characteristics of AN connectivity of MDD patients before and after repetitive transcranial magnetic stimulation (rTMS) treatment over the left dorsolateral prefrontal cortex, and to further assess how these connectivity changes are linked to clinical characteristics of patients. Functional connectivity (FC) in the AN defined by placing seeds in the bilateral amygdale was calculated in 20 patients with MDD before and after rTMS, and in 20 healthy controls (CN). Furthermore, a linear regression model was used to obtain correlations between FC changes and Hamilton depression scale (HAMD) changes in MDD before and after rTMS. Before rTMS, compared with CN, MDD exhibited significantly lower FC between left insula (INS.L), right superior and inferior frontal gyrus (SFG.R and IFG.R), right inferior parietal lobule (IPL.R), and amygdala, and showed an increment of FC between the bilateral precuneus and amygdala in AN. After rTMS, MDD exhibited a significant increase in FC in the INS.L, IFG.R, SFG.R, IPL.R, and a significant reduction in FC in the precuneus. Interestingly, change in FC between INS.L and left amygdala was positively correlated with change in HAMD scores before and after rTMS treatment. rTMS can enhance affective network connectivity in MDD patients, which is linked to emotional improvement. This study further suggests that the insula may be a potential target region of clinical efficacy for MDD to design rationale strategies for therapeutic trials.

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Italian patients with more recent onset of Major Depressive Disorder have a shorter duration of untreated illness

Cited by 9 publications

References 40 publications

Clinical features and patterns of psychopharmacological prescription in bipolar patients with vs without anxiety disorders at onset

Clinical features and patterns of psychopharmacological prescription in bipolar patients with vs without anxiety disorders at onset

Duration of untreated illness; year of onset early/late and Gender differences, symptoms in patients with Major depressive disorder. an eighteen month, cross-sectional, clinical study in southwest China

Repetitive Transcranial Magnetic Stimulation Improves Amygdale Functional Connectivity in Major Depressive Disorder

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