Protective effects of exercise training on endothelial dysfunction induced by total sleep deprivation in healthy subjects

Sauvet, Fabien; Arnal, Pierrick J.; Tardo-Dino, Pierre Emmanuel; Drogou, Catherine; Beers, Pascal Van; Bougard, Clément; Rabat, Arnaud; Malgoyre, Alexandra; Léger, Damien; Gomez-Mérino, Danielle; Chennaoui, Mounir

doi:10.1016/j.ijcard.2017.01.049

Cited by 21 publications

(5 citation statements)

References 55 publications

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“…While all treatment groups showed a tendency to decrease compared to after SD, there was no significant difference. This result is consistent with earlier studies [ 61 , 73 ]. It is known that hs-CRP increases during an inflammatory response and is a non-specific response to cell and tissue metabolism, serving as an increased risk factor for cardiovascular disease prognostic factors [ 74 ].…”

Section: Discussionsupporting

confidence: 94%

The Effect of Aerobic Exercise on Variation of Oxidative Stress, hs-CRP and Cortisol Induced by Sleep Deficiency

2023

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The aim of this study was to investigate the impact of sleep deficiency (SD) on oxidative stress, hs-CRP and cortisol levels and to examine the effects of different intensities of aerobic exercise on these parameters under SD conditions. Thirty-two healthy male university students participated in the study and underwent both normal sleep (NS, 8 h of sleep per night for 3 consecutive days) and SD (4 h of sleep per night for 3 consecutive days). After the SD period, the participants performed treatment for 30 min according to their assigned group [sleep supplement after SD (SSD), low-intensity aerobic exercise after SD (LES), moderate-intensity aerobic exercise after SD (MES), high-intensity aerobic exercise after SD (HES)]. Sleep-related factors were measured at NS and SD, while oxidative stress, hs-CRP and cortisol levels were measured at NS, SD and immediately after treatment by group (AT). The results showed that actual total sleep time (ATST) was significantly reduced during SD compared to NS (p < 0.001), while the visual analogue scale (VAS) and Epworth sleepiness scale (ESS) were significantly increased during SD compared to NS (p < 0.001). The difference in reactive oxygen metabolites (d-ROMs) and cortisol levels showed a significant interaction effect (p < 0.01, p < 0.001, respectively), with LES showing a decrease in d-ROMs and cortisol levels compared to SD (p < 0.05). Similarly, SSD showed a decrease in cortisol levels compared to SD (p < 0.05), while HES led to a significant increase in d-ROMs and cortisol levels compared to SD (p < 0.05). Biological antioxidant potential (BAP) and hs-CRP did not show any significant effect (p > 0.05). These results suggest that LES is the most effective exercise intensity for mitigating the negative effects of SD.

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Section: Discussionsupporting

confidence: 94%

The Effect of Aerobic Exercise on Variation of Oxidative Stress, hs-CRP and Cortisol Induced by Sleep Deficiency

2023

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“…NO-mediated impairment of vasodilation contributes to atherosclerotic vascular disease and acute cardiovascular events. Prospective studies by Bain et al [ 104 ], Sauvet et al [ 105 ], and Stockelman et al [ 106 ] showed that short sleep duration at night was associated with endothelium-dependent vasodilation dysfunction. This may be partly due to reduced bioavailability of NO, which leads to impaired vasodilation.…”

Section: Mechanisms Of Chd Caused By Sdmentioning

confidence: 99%

Effects of sleep deprivation on coronary heart disease

Wei

Duan

Guo

2022

Korean J Physiol Pharmacol

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The presence of artificial light enables humans to be active 24 h a day. Many people across the globe live in a social culture that encourages staying up late to meet the demands of various activities, such as work and school. Sleep deprivation (SD) is a severe health problem in modern society. Meanwhile, as with cardiometabolic disease, there was an obvious tendency that coronary heart disease (CHD) to become a global epidemic chronic disease. Specifically, SD can significantly increase the morbidity and mortality of CHD. However, the underlying mechanisms responsible for the effects of SD on CHD are multilayered and complex. Inflammatory response, lipid metabolism, oxidative stress, and endothelial function all contribute to cardiovascular lesions. In this review, the effects of SD on CHD development are summarized, and SD-related pathogenesis of coronary artery lesions is discussed. In general, early assessment of SD played a vital role in preventing the harmful consequences of CHD.

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“…The endothelial dysfunction increases the levels of proinflammatory cytokines, which activate inflammatory pathways and contribute to thrombus formation and vascular occlusion, resulting in myocardial infarctions and strokes [57][58][59][60] . Additionally, increasing evidence has demonstrated that the mood state might have effects on the endothelial function [61,62] . In a mouse carotid artery model, the stressed mice had increased levels of endothelial-function markers, such as vascular cell adhesion molecule-1 (VCAM-1) and intracellular adhesion molecule-1 (ICAM-1), and accelerated damage of arterial endothelial cells [63] .…”

Section: Roles Of Endothelial Dysfunctionmentioning

confidence: 99%

Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage

et al. 2022

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Coronavirus disease 2019 (COVID-19) has caused a global pandemic impacting over 200 countries/regions and more than 200 million patients worldwide. Among the infected patients, there is a high prevalence of COVID-19-related cardiovascular injuries. However, the specific mechanisms linking cardiovascular damage and COVID-19 remain unclear. The COVID-19 pandemic also has exacerbated the mental health burden of humans. Considering the close association between neuroimmune interactions and cardiovascular disease, this review assessed the complex pathophysiological mechanisms connecting neuroimmune interactions and cardiovascular disease. It was revealed that the mental health burden might be a pivotal accomplice causing COVID-19-associated cardiovascular damage. Specifically, the proinflammatory status of patients with a terrible mood state is closely related to overdrive of the hypothalamus-pituitary-adrenal (HPA) axis, sympathovagal imbalance, and endothelial dysfunction, which lead to an increased risk of developing cardiovascular injury during COVID-19. Therefore, during the prevention and treatment of cardiovascular complications in COVID-19 patients, particular attention should be given to relieve the mental health burden of these patients.

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Protective effects of exercise training on endothelial dysfunction induced by total sleep deprivation in healthy subjects

Cited by 21 publications

References 55 publications

The Effect of Aerobic Exercise on Variation of Oxidative Stress, hs-CRP and Cortisol Induced by Sleep Deficiency

The Effect of Aerobic Exercise on Variation of Oxidative Stress, hs-CRP and Cortisol Induced by Sleep Deficiency

Effects of sleep deprivation on coronary heart disease

Role of Neuroimmune Interactions in COVID-19-related Cardiovascular Damage

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