Fibrin glue for pilonidal sinus disease

Lund, Jonathan N.; Tou, Samson; Doleman, Brett; Williams, John P.

doi:10.1002/14651858.cd011923.pub2

Cited by 35 publications

(31 citation statements)

References 24 publications

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“…Few RCTs have been conducted in patients with pilonidal sinus disease to investigate the effectiveness of different dressings 14,15 . Biter et al 1 showed the feasibility of using negative-pressure wound therapy (NPWT) after pilonidal sinus excision.…”

Section: Discussionmentioning

confidence: 99%

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

et al. 2020

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Background Disease of the pilonidal sinus is a common condition that affects mainly young adults. Options for management include excision of the sinus tracts, leaving the wound open to heal by secondary intention. The aim of this study was to compare wound healing with dialkylcarbamoyl chloride (DACC)‐coated dressings versus alginate dressings. Methods This multicentre trial randomized consecutive patients undergoing surgery for pilonidal disease to postoperative wound care with either DACC‐coated or alginate dressings. The primary outcome was the proportion of wounds healed after 75 days. Secondary outcomes were the local status of wounds during the healing process, the quality assessment of the dressings by the patient, and the time needed to return to usual activities. Results A total of 246 patients were included: 120 in the DACC‐coated group and 126 in the alginate group. In per‐protocol analysis, there were significantly more patients with completely healed wounds after 75 days in the DACC group than in the alginate group: 78 of 103 (75·7 per cent) versus 58 of 97 (60 per cent) respectively (odds ratio 2·55, 95 per cent c.i. 1·12 to 5·92; P = 0·023). During follow‐up, wounds with alginate dressings had more fibrin than those with DACC‐coated dressings, but the difference was not significant (P = 0·079). There was no difference between the two arms in patients' assessment of the dressings. Conclusion The number of wounds completely healed at 75 days was significantly higher for DACC‐coated compared with alginate dressings. However, the preplanned, clinically significant improvement in healing of 20 per cent was not reached. Registration number: NCT02011802 ( https://clinicaltrials.gov/).

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Section: Discussionmentioning

confidence: 99%

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

et al. 2020

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“…Of the 18 Cochrane reviews that reported using a citation index to conduct citation searching, 15 (83%) reported the name of the citation index(es) used. Google Scholar was reported in one review 55 ; Scopus was reported in two reviews 24,29 ; and Web of Science was reported in 13 reviews, [26][27][28][29]31,32,[34][35][36][37][38][39][40] including seven reviews [26][27][28][29]32,34,39 that reported searching the Science Citation Index (a subset of the Web of Science) in particular and one review 35 that reported searching the Core Collection (which includes the Social Sciences Citation Index and Arts & Humanities Citation Index) in particular.…”

Section: What Citation Indexes Are Used and How Frequently?mentioning

confidence: 99%

Conduct and reporting of citation searching in Cochrane systematic reviews: A cross‐sectional study

Briscoe

Bethel

Rogers

2019

Research Synthesis Methods

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Background The search for studies for a systematic review should be conducted systematically and reported transparently to facilitate reproduction. This study aimed to report on the conduct and reporting of backward citation searching (ie, checking reference lists) and forward citation searching in a cross section of Cochrane reviews. Citation searching uses the citation network surrounding a source study to identify additional studies. Methods Cochrane reviews were identified by searching the Cochrane Database of Systematic Reviews using the wildcard symbol and date limiting to the 3‐month period November 2016 to January 2017. Cochrane reviews thus identified were screened for mention of citation searching. Descriptive detail on the conduct and reporting of citation searching was captured in data extraction forms and described and evaluated. Results Two hundred fifteen Cochrane reviews were identified. One hundred seventy‐two reviews reported backward citation searching, and 18 reviews reported forward citation searching. Web of Science was the most frequently reported citation index. The studies used for backward citation searching consisted mainly of studies meeting the inclusion criteria. One‐third of reviews that reported forward citation searching used selected studies of importance. Reporting of citation searching was compliant with the Methodological Expectations of Cochrane Intervention Reviews (MECIR) standards, but full transparency requires additional detail that only a minority of reviews reported. Conclusion The conduct of backward citation searching was more uniform than forward citation searching. This might be due to lack of MECIR guidance for forward citation searching. Reporting was generally compliant with MECIR, but this is not always sufficient to ensure full transparency.

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“…74% required no further treatment; of those that did have further treatment, 3 out of 15 had repeat glue treatment that resulted in complete healing. A Cochrane review performed in 2017 included 4 RCTs with the intervention of fibrin glue as monotherapy or as a surgical adjunct in a total of 253 patients . When fibrin glue was used as a monotherapy compared with Bascom's procedure there was low‐quality evidence to support less pain on day one after the procedure and shorter time to return to normal activities, no data were available on time to healing or adverse events.…”

Section: Chronic Disease Treatmentsmentioning

confidence: 99%

“…A Cochrane review performed in 2017 included 4 RCTs with the intervention of fibrin glue as monotherapy or as a surgical adjunct in a total of 253 patients. 34 When fibrin glue was used as a monotherapy compared with Bascom's procedure there was low-quality evidence to support less pain on day one after the procedure and shorter time to return to normal activities, no data were available on time to healing or adverse events. Fibrin glue as an adjunct to the Limberg flap may reduce healing time, postoperative pain, and time to return to normal activities but with a possible incidence of postoperative seroma.…”

Section: Fibrin Gluementioning

confidence: 99%

Management of sacrococcygeal pilonidal sinus disease

Harries

Alqallaf

Torkington

et al. 2018

International Wound Journal

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The ideal treatment for patients who suffer from pilonidal sinus disease should lead to a cure with a rapid recovery period allowing a return to normal daily activities, with a low level of associated morbidity. A variety of different surgical techniques have been described for the primary treatment of pilonidal sinus disease and current practice remains variable and contentious. Whilst some management options have improved outcomes for some patients, the complications of surgery, particularly related to wound healing, often remain worse than the primary disease. This clinical review aims to provide an update on the management options to guide clinicians involved in the care of patients who suffer from sacrococcygeal pilonidal sinus disease.

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Fibrin glue for pilonidal sinus disease

Cited by 35 publications

References 24 publications

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

Dialkylcarbamoyl chloride-coated versus alginate dressings after pilonidal sinus excision: a randomized clinical trial (SORKYSA study)

Conduct and reporting of citation searching in Cochrane systematic reviews: A cross‐sectional study

Management of sacrococcygeal pilonidal sinus disease

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