The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study

Gülşen, İsmail; Ak, Hakan; Kara, Mikail; Gökalp, Abdulsemat; Akyol, Veysel; Koçak, Ömer Faruk; Rağbetli, Murat Çetin

doi:10.5505/tjtes.2016.40204

Cited by 5 publications

(2 citation statements)

References 23 publications

(32 reference statements)

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“…TQ has great anti-inflammatory and antioxidant activities and is frequently utilized in studies on antidiabetic, anticancer, cardioprotective, and neuroprotective studies. The anti-inflammatory activity of TQ has been reported to be based on its ability to effectively inhibit the activation of TLR4 and its downstream inflammatory pathways. , There is evidence that TQ has a protective effect on the sciatic nerve and DRG in peripheral nerve injury , and can reduce peripheral neuropathy caused by diabetes. , In addition, there is preliminary in vitro evidence that TQ can prevent cisplatin-mediated neurotoxicity in primary DRG neurons, but the mechanism of action is unclear …”

Section: Introductionmentioning

confidence: 99%

Thymoquinone Alleviates Paclitaxel-Induced Peripheral Neuropathy through Regulation of the TLR4-MyD88 Inflammatory Pathway

Xing,

Zhang,

You

et al. 2023

ACS Chem. Neurosci.

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Paclitaxel-induced peripheral neuropathy (PIPN) is one of the common adverse effects during the paclitaxel (PTX) treatment of cancer. In this study, we investigated the neuroprotective effects and mechanisms of thymoquinone (TQ) in the PIPN model. Through pain behavioral assays and histological assessment, we demonstrated that TQ significantly alleviated the nociceptive behavior, modulated the pathological changes in peripheral nerves, and decreased the expression of inflammatory factors TNF-α, IL-1β, and IL-6 induced by PIPN in mice. In addition, TQ significantly reversed the reduced viability and inflammatory response of primary DRG neurons caused by PTX. Moreover, the gene expression of related pathways was detected by Western blot, qPCR, and immunofluorescence, and the results showed that TQ exerts neuroprotective effects by regulating TLR4/MyD88 and its downstream NF-κB and MAPKs inflammatory pathways in vivo and in vitro. The treatment with TLR4 antagonist TAK-242 further indicated the important role of the TLR4/MyD88 signaling pathway in PIPN. Furthermore, molecular docking and a cellular thermal shift assay were used to confirm the interaction of TQ with TLR4. In summary, our study shows that TQ can inhibit inflammatory responses against PIPN by regulating TLR4 and MyD88 and its downstream inflammatory pathways.

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Section: Introductionmentioning

confidence: 99%

Thymoquinone Alleviates Paclitaxel-Induced Peripheral Neuropathy through Regulation of the TLR4-MyD88 Inflammatory Pathway

Xing,

Zhang,

You

et al. 2023

ACS Chem. Neurosci.

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show abstract

“…Therefore, several chemical agents with antioxidant and antiinflammatory effect have been evaluated for their ability to inhibit this cascade [3][4][5]11) Methylprednisolone and gabapentin are the reference agents and have shown beneficial effects in the literature 26) . But, although they have beneficial effects on parenchymal damage, there is no significant improvement on functional recovery and there are several side effects associated with their use 7) .…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Effects of Lacosamide in Experimental Peripheral Nerve Injury in Rats : A Prospective Randomized and Placebo-Controlled Trial

Demiröz¹,

Bengü

et al. 2020

J Korean Neurosurg Soc

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Objective : To evaluate the neuroprotective effects of lacosamide after experimental peripheral nerve injury in rats. Methods : A total of 28 male wistar albino rats weighing 300-350 g were divided into four groups. In group I, the sciatic nerve exposed and the surgical wound was closed without injury; in group II, peripheral nerve injuries (PNI) was performed after dissection of the nerve; in group III, PNI was performed after dissection and lacosamide was administered, and in group IV, PNI was performed after dissection and physiological saline solution was administered. At 7 days after the injury all animals were sacrificed after walking track analysis. A 5 mL blood sample was drawn for biochemical analysis, and sciatic nerve tissues were removed for histopathological examination. Results : There is low tissue damage in lacosamide treated group and antioxidant anzymes and malondialdehyde levels were higher than non-treated and placebo treated group. However there was no improvement on clinical assessment. Conclusıon : The biochemical and histological analyses revealed that lacosamide has neuroprotective effect in PNI in rats. This neuroprotective capacity depends on its scavenger role for free oxygen radicals by increasing antioxidant enzyme activity.

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Thymoquinone modifies CD4+:CD8+ ratio without affecting tumor necrosis factor-α and interleukin-1β levels in Wallerian degeneration crush injury rat model

Besin,

Bajamal,

Nugraha

et al. 2024

Neurosci Behav Physi

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The acute effects of thymoquinone on acute peripheral nerve injury: an experimental study

Abstract: BACKGROUND:The purpose of this study was to evaluate the acute effects of thymoquinone (TQ) on acute nerve injury.

Cited by 5 publications

References 23 publications

Thymoquinone Alleviates Paclitaxel-Induced Peripheral Neuropathy through Regulation of the TLR4-MyD88 Inflammatory Pathway

Thymoquinone Alleviates Paclitaxel-Induced Peripheral Neuropathy through Regulation of the TLR4-MyD88 Inflammatory Pathway

Neuroprotective Effects of Lacosamide in Experimental Peripheral Nerve Injury in Rats : A Prospective Randomized and Placebo-Controlled Trial

Thymoquinone modifies CD4+:CD8+ ratio without affecting tumor necrosis factor-α and interleukin-1β levels in Wallerian degeneration crush injury rat model

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