Microneedle-Assisted Skin Permeation by Nontoxic Bioengineerable Gas Vesicle Nanoparticles

Andar, Abhay; Karan, Ram; Pecher, Wolf T.; DasSarma, Priya; Hedrich, William D.; Stinchcomb, Audra L.; DasSarma, Shiladitya

doi:10.1021/acs.molpharmaceut.6b00859

Cited by 22 publications

(24 citation statements)

References 44 publications

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“…While most investigations have carried out with the intramuscular, intraperitoneal or subcutaneous route of vaccination, alternative routes, such as transdermal or mucosal routes may be attractive alternatives, as they are needle free and may induce potent mucosal immunity in addition to systemic immunity. Several studies on these alternative routes have been performed with archaeosomes, but these routes have yet attracted limited attention for GVNPs, although one study has explored the transdermal route of vaccination with GVNPs (48). While GVNPs, like archaeosomes have in-built adjuvant properties, the addition of exogenous adjuvants that orient and further strengthen the desired immune responses have only recently started to be explored for archaeosomes, but have not yet been investigated with GVNPs.…”

Section: Discussionmentioning

confidence: 99%

Archaeosomes and Gas Vesicles as Tools for Vaccine Development

et al. 2021

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Archaea are prokaryotic organisms that were classified as a new domain in 1990. Archaeal cellular components and metabolites have found various applications in the pharmaceutical industry. Some archaeal lipids can be used to produce archaeosomes, a new family of liposomes that exhibit high stability to temperatures, pH and oxidative conditions. Additionally, archaeosomes can be efficient antigen carriers and adjuvants promoting humoral and cellular immune responses. Some archaea produce gas vesicles, which are nanoparticles released by the archaea that increase the buoyancy of the cells and facilitate an upward flotation in water columns. Purified gas vesicles display a great potential for bioengineering, due to their high stability, immunostimulatory properties and uptake across cell membranes. Both archaeosomes and archaeal gas vesicles are attractive tools for the development of novel drug and vaccine carriers to control various diseases. In this review we discuss the current knowledge on production, preparation methods and potential applications of archaeosomes and gas vesicles as carriers for vaccines. We give an overview of the traditional structures of these carriers and their modifications. A comparative analysis of both vaccine delivery systems, including their advantages and limitations of their use, is provided. Gas vesicle- and archaeosome-based vaccines may be powerful next-generation tools for the prevention and treatment of a wide variety of infectious and non-infectious diseases.

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Section: Discussionmentioning

confidence: 99%

Archaeosomes and Gas Vesicles as Tools for Vaccine Development

et al. 2021

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“…Their MN was bioinspired by the gas vesicles, hollow, buoyant protein organelles, produced by the extremophilic microbe Halobacterium sp. [42] Lee et al developed dissolving MN using the biomaterials-amylopectin and carboxymethylcellulose-achieving a bolus or sustained drug release. [43] Chitosan-and PLA-based MN were used for transdermal vaccination purposes.…”

Section: Transdermal Drug Deliverymentioning

confidence: 99%

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

Rahamim

Azagury

2021

Adv Funct Materials

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The main purpose herein is to provide an up-to-date review on noninvasive biomimetic, bioinspired, and bioengineered drug delivery system (DDS). Noninvasive DDS is an ever-growing field critical for the applicability of drugs. It offers noninvasive administration routes with improved controlled, targeted, and triggered drug delivery. Noninvasive DDS employ many approaches and strategies, such as, nano-and microparticles, lipid-based systems, sonophoresis, electrophoresis and iontophoresis, penetration enhancers, microneedles, and gels. The last decade seen a surge in research papers employing the paradigms of biomimicry, bioinspiration, and bioengineering. However, since the use of these terms in noninvasive DDS field is often inconsistent and unclear, some generalized perspectives are provided on the possible usage of these terms in future publications. Additionally, a critical discussion on the novelty and origins of these paradigms is provided. The advantages and disadvantages of each of the noninvasive routes and their current main limitations are summarized. The main aspects of indicated fields are discussed: The unique physiology of the related tissues, the main hurdles for mass transport, the various DDS tested, and materials selection. Finally, the basic concepts and therapeutic effects of these DDS are discussed and future venues for noninvasive biomimetic, bioinspired, and bioengineered DDS research are proposed.

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“…The conformation of key proteins when displaying the antigens described above also remains unknown. Investigations into the optimal delivery route for these GVNPs are ongoing, with one study investigating the use of micro-needles to enhance skin permeation of the particles, with a view to developing them as a drug delivery system [78].…”

Section: The Use Of Gas Vesicles In Engineering Vaccinesmentioning

confidence: 99%

Microbial gas vesicles as nanotechnology tools: exploiting intracellular organelles for translational utility in biotechnology, medicine and the environment

Hill

Salmond

2020

Microbiology

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A range of bacteria and archaea produce gas vesicles as a means to facilitate flotation. These gas vesicles have been purified from a number of species and their applications in biotechnology and medicine are reviewed here. Halobacterium sp. NRC-1 gas vesicles have been engineered to display antigens from eukaryotic, bacterial and viral pathogens. The ability of these recombinant nanoparticles to generate an immune response has been quantified both in vitro and in vivo. These gas vesicles, along with those purified from Anabaena flos-aquae and Bacillus megaterium , have been developed as an acoustic reporter system. This system utilizes the ability of gas vesicles to retain gas within a stable, rigid structure to produce contrast upon exposure to ultrasound. The susceptibility of gas vesicles to collapse when exposed to excess pressure has also been proposed as a biocontrol mechanism to disperse cyanobacterial blooms, providing an environmental function for these structures.

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Microneedle-Assisted Skin Permeation by Nontoxic Bioengineerable Gas Vesicle Nanoparticles

Cited by 22 publications

References 44 publications

Archaeosomes and Gas Vesicles as Tools for Vaccine Development

Archaeosomes and Gas Vesicles as Tools for Vaccine Development

Bioengineered Biomimetic and Bioinspired Noninvasive Drug Delivery Systems

Microbial gas vesicles as nanotechnology tools: exploiting intracellular organelles for translational utility in biotechnology, medicine and the environment

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