“…At present, there are many measures for screening fetal CNS malformations, including fetal tissue biopsy, fetal blood sample collection, chorionic cell sampling, and amniocentesis. However, they are all invasive examinations that can cause damage to the fetus, and their safety is low[ 10 - 13 ]. Moreover, ultrasonography is commonly used for fetal malformations, and two-dimensional ultrasonography has many advantages, such as real-time monitoring, low cost, simplicity, and a quick procedure.…”