Single nucleotide polymorphisms in ZNRD1-AS1 increase cancer risk in an Asian population

Abstract

Single nucleotide polymorphisms (SNPs) in human zinc ribbon domain containing 1 antisense RNA 1 (ZNRD1-AS1) have been associated with cancer development. In this meta-analysis, we more precisely estimated the associations between three expression quantitative trait loci SNPs in ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) and cancer susceptibility. The data for three SNPs were extracted from eligible studies, which included 5,293 patients and 5,440 controls. Overall, no significant associations between SNPs in ZNRD1-AS1 (rs3757328, rs6940552, and rs9261204) and cancer risk were observed. However, in further subgroup analyses based on cancer type, we found that the A allele of rs3757328 increased the risk of some cancer in both allele contrast (OR = 1.15, 95% CI = 1.05 – 1.25) and recessive models (OR = 1.79; 95% CI = 1.33 – 2.41). The A allele of rs6940552 and the G allele of rs9261204 also increased the risk of some cancer in an Asian population in allele contrast (OR = 1.17, 95% CI = 1.08 – 1.26, and OR = 1.25, 95% CI = 1.16 – 1.34, respectively) and recessive models (OR = 1.44, 95% CI = 1.18 – 1.77, and OR = 1.49; 95% CI = 1.23 – 1.80, respectively). Thus, rs3757328, rs6940552, and rs9261204 in ZNRD1-AS1 are all associated with increased some cancer risk in an Asian population.

Associations of GWAS-Identified Risk Loci with Progression, Efficacy and Toxicity of Radiotherapy of Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy

“…SNP rs259919 was located in the lncRNA ZNRD1-AS1 region, which have reported to associated with bladder cancer, nasopharyngeal carcinoma, breast cancer, glioma, endometrial cancer, hepatocellular carcinoma, lung cancer, and cervical cancer. [15][16][17][18][19][20][21][22][23][24] Interestingly, we found rs3135001 was significantly associated with better efficacy of radiotherapy and fewer grade 3-4 oral mucositis. Using RegulomeDB 2.0, we found rs3135001 was located in a TF binding or DNase peak region.…”

Integrative analysis of competitive endogenous RNA network reveals the regulatory role of non-coding RNAs in high-glucose-induced human retinal endothelial cells

“…Therefore, it is essential to determine the molecular mechanism of lncRNAs to reduce the rate of vision loss of DR. ZNRD1-AS1, MEG3, OIP5-AS1 and TPTEP1 are the four key lncRNAs in the ceRNA network. ZNRD1-AS1 it is thought to be related to the progression of cancer (Li et al, 2016;Wang et al, 2017). Two recent studies showed that the expression of ZNRD1-AS1 is associated with the development and susceptibility of hepatocellular carcinoma and cervical cancer (Guo et al, 2015;Wen et al, 2015).…”

Genetic Polymorphisms in NLRP3 Inflammasome-Associated Genes in Patients with B-Cell Non-Hodgkin’s Lymphoma

“…Genetic analysis of B-NHL tumor microenvironment revealed different genetic characteristics related to the survival. 5 Functional single nucleotide polymorphisms (SNPs) can affect both the inflammatory microenvironment around the malignant tumor 6 and directly the malignant B cells. 7 Inflammasomes contain a number of cytoplasmic NOD-like receptors (NLR).…”